Abstract
Differentiation of membrane channel models based on fluctuation (or noise) analysis is discussed. The theory is particularly useful in distinguishing a single-conductance model (Hodgkin-Huxley formalism) from a multiconductance model. When applied to the frog node of Ranvier, it seems likely that the potassium channels of the membrane may have multiconductance states.
Full text
PDF






Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Begenisich T., Stevens C. F. How many conductance states do potassium channels have? Biophys J. 1975 Aug;15(8):843–846. doi: 10.1016/S0006-3495(75)85858-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen Y. D., Hill T. L. Fluctuations and noise in kinetic systems. Application to K+ channels in the squid axon. Biophys J. 1973 Dec;13(12):1276–1295. doi: 10.1016/S0006-3495(73)86062-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Colquhoun D., Dionne V. E., Steinbach J. H., Stevens C. F. Conductance of channels opened by acetylcholine-like drugs in muscle end-plate. Nature. 1975 Jan 17;253(5488):204–206. doi: 10.1038/253204a0. [DOI] [PubMed] [Google Scholar]
- Conti F., De Felice L. J., Wanke E. Potassium and sodium ion current noise in the membrane of the squid giant axon. J Physiol. 1975 Jun;248(1):45–82. doi: 10.1113/jphysiol.1975.sp010962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill T. L., Chen Y. D. On the theory of ion transport across the nerve membrane. IV. Noise from the open-close kinetics of K + channels. Biophys J. 1972 Aug;12(8):948–959. doi: 10.1016/S0006-3495(72)86136-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
