Abstract
OBJECTIVE: To determine whether residents of Ontario who are exposed to radium 226 naturally occurring in drinking water are at increased risk of bone cancer. DESIGN: A population-based case-control study of records from death and birth registries. Water samples were obtained from residences at the time of birth and of death. SETTING: Ontario. PARTICIPANTS: All Ontario-born people under the age of 26 years who died of bone cancer between 1950 and 1983. Control subjects were those who died of any other disease matched by age, sex and year of death. OUTCOME MEASURES: Radium exposure distributions and estimation of risk. RESULTS: An association was found between death from bone cancer and exposure to radium at the birthplace residence in concentrations of 7.0 mBq/L or more (odds ratio 1.58, 90% confidence interval [CI] 1.01 to 2.50; p = 0.047). There was a statistically significant exposure-response relation (p = 0.045). The increase in risk was similar for the main types of childhood bone cancer: osteosarcoma, Ewing's sarcoma and chondrosarcoma. CONCLUSIONS: The estimated risk at these exposure levels is much higher than would be predicted. The association may be spurious, the point estimates of risk may be too high, or risk factors derived from other exposure circumstances may not be valid for exposure to radium beginning in the prenatal period. Should the findings be confirmed, consideration might be given to removing radium from drinking-water sources.
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- Bean J. A., Isacson P., Hahne R. M., Kohler J. Drinking water and cancer incidence in Iowa. II. Radioactivity in drinking water. Am J Epidemiol. 1982 Dec;116(6):924–932. doi: 10.1093/oxfordjournals.aje.a113494. [DOI] [PubMed] [Google Scholar]
- Friend S. H., Dryja T. P., Weinberg R. A. Oncogenes and tumor-suppressing genes. N Engl J Med. 1988 Mar 10;318(10):618–622. doi: 10.1056/NEJM198803103181007. [DOI] [PubMed] [Google Scholar]
- Kriege L. B., Hahne R. M. 226Ra and 228Ra in Iowa drinking water. Health Phys. 1982 Oct;43(4):543–559. doi: 10.1097/00004032-198210000-00008. [DOI] [PubMed] [Google Scholar]
- Lyman G. H., Lyman C. G., Johnson W. Association of leukemia with radium groundwater contamination. JAMA. 1985 Aug 2;254(5):621–626. [PubMed] [Google Scholar]
- Mays C. W., Rowland R. E., Stehney A. F. Cancer risk from the lifetime intake of Ra and U isotopes. Health Phys. 1985 May;48(5):635–647. doi: 10.1097/00004032-198505000-00005. [DOI] [PubMed] [Google Scholar]
- Michel J., Moore W. S. 228Ra and 226Ra content of groundwater in Fall Line aquifers. Health Phys. 1980 Apr;38(4):663–671. doi: 10.1097/00004032-198004000-00014. [DOI] [PubMed] [Google Scholar]
- Neuberger J. S. Residential radon exposure and lung cancer: an overview of ongoing studies. Health Phys. 1992 Nov;63(5):503–509. doi: 10.1097/00004032-199211000-00001. [DOI] [PubMed] [Google Scholar]
- Petersen N. J., Samuels L. D., Lucas H. F., Abrahams S. P. An epidemiologic approach to low-level radium 226 exposure. Public Health Rep. 1966 Sep;81(9):805–814. [PMC free article] [PubMed] [Google Scholar]
- Rowland R. E., Stehney A. F., Lucas H. F. Dose-response relationships for radium-induced bone sarcomas. Health Phys. 1983;44 (Suppl 1):15–31. doi: 10.1097/00004032-198306001-00001. [DOI] [PubMed] [Google Scholar]
- Tucker M. A., D'Angio G. J., Boice J. D., Jr, Strong L. C., Li F. P., Stovall M., Stone B. J., Green D. M., Lombardi F., Newton W. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med. 1987 Sep 3;317(10):588–593. doi: 10.1056/NEJM198709033171002. [DOI] [PubMed] [Google Scholar]
- Wrenn M. E., Durbin P. W., Howard B., Lipsztein J., Rundo J., Still E. T., Willis D. L. Metabolism of ingested U and Ra. Health Phys. 1985 May;48(5):601–633. doi: 10.1097/00004032-198505000-00004. [DOI] [PubMed] [Google Scholar]