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. 1995 Jan 15;152(2):193–195.

Critical clue to ethylene glycol poisoning.

K M Huhn 1, F M Rosenberg 1
PMCID: PMC1337574  PMID: 7820801

Abstract

The authors report the case of a man 49 years of age with near-fatal ethylene glycol poisoning. Detection of calcium oxalate monohydrate crystals in the urine was the only real-time confirmation of the diagnosis. The case illustrates that, if the toxin has already been metabolized, familiarity with the appearance and significance of this unusual form of calcium oxalate crystal may be the key to an accurate diagnosis.

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Selected References

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  1. Burkhart K. K., Kulig K. W. The other alcohols. Methanol, ethylene glycol, and isopropanol. Emerg Med Clin North Am. 1990 Nov;8(4):913–928. [PubMed] [Google Scholar]
  2. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  3. Gabow P. A., Kaehny W. D., Kelleher S. P. The spectrum of rhabdomyolysis. Medicine (Baltimore) 1982 May;61(3):141–152. doi: 10.1097/00005792-198205000-00002. [DOI] [PubMed] [Google Scholar]
  4. Godolphin W., Meagher E. P., Sanders H. D., Frohlich J. Unusual calcium oxalate crystals in ethylene glycol poisoning. Clin Toxicol. 1980 Jun;16(4):479–486. doi: 10.3109/15563658008989977. [DOI] [PubMed] [Google Scholar]
  5. Hagen L., Walker V. R., Sutton R. A. Plasma and urinary oxalate and glycolate in healthy subjects. Clin Chem. 1993 Jan;39(1):134–138. [PubMed] [Google Scholar]
  6. Jacobsen D., Akesson I., Shefter E. Urinary calcium oxalate monohydrate crystals in ethylene glycol poisoning. Scand J Clin Lab Invest. 1982 May;42(3):231–234. doi: 10.1080/00365518209168078. [DOI] [PubMed] [Google Scholar]
  7. Jacobsen D., McMartin K. E. Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment. Med Toxicol. 1986 Sep-Oct;1(5):309–334. doi: 10.1007/BF03259846. [DOI] [PubMed] [Google Scholar]
  8. Litovitz T. L., Holm K. C., Clancy C., Schmitz B. F., Clark L. R., Oderda G. M. 1992 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 1993 Sep;11(5):494–555. doi: 10.1016/0735-6757(93)90093-q. [DOI] [PubMed] [Google Scholar]
  9. Palmer B. F., Eigenbrodt E. H., Henrich W. L. Cranial nerve deficit: a clue to the diagnosis of ethylene glycol poisoning. Am J Med. 1989 Jul;87(1):91–92. doi: 10.1016/s0002-9343(89)80489-9. [DOI] [PubMed] [Google Scholar]
  10. Porter W. H., Auansakul A. Gas-chromatographic determination of ethylene glycol in serum. Clin Chem. 1982 Jan;28(1):75–78. [PubMed] [Google Scholar]
  11. Ryder K. W., Glick M. R., Jackson S. A. Emergency screening for ethylene glycol in serum. Clin Chem. 1986 Aug;32(8):1574–1577. [PubMed] [Google Scholar]
  12. Simpson E. Some aspects of calcium metabolism in a fatal case of ethylene glycol poisoning. Ann Clin Biochem. 1985 Jan;22(Pt 1):90–93. doi: 10.1177/000456328502200110. [DOI] [PubMed] [Google Scholar]
  13. Steinhart B. Case report: severe ethylene glycol intoxication with normal osmolal gap--"a chilling thought". J Emerg Med. 1990 Sep-Oct;8(5):583–585. doi: 10.1016/0736-4679(90)90454-4. [DOI] [PubMed] [Google Scholar]

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