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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 1967 Nov;10(6):555–563. doi: 10.1901/jeab.1967.10-555

Adrenocortical influences on free-operant avoidance behavior1

George A Wertheim, Robert L Conner, Seymour Levine
PMCID: PMC1338428  PMID: 4295216

Abstract

Rats were conditioned to avoid shock on a free-operant avoidance schedule in which no exteroceptive stimulus signaled impending shock. Injections of adrenocorticotropic hormone (ACTH) or dexamethasone raised blood levels of glucocorticoids. These increases were accompanied by changes in avoidance performance: there was a higher frequency of long-duration interresponse times, a greater stability among them, and fewer short interresponse times, total responses, and shocks.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOHUS B., ENDROECZI E., LISSAK K. CORRELATIONS BETWEEN AVOIDING CONDITIONED REFLEX ACTIVITY AND PITUITARY-ADRENOCORTICAL FUNCTION IN THE RAT. Acta Physiol Acad Sci Hung. 1963;24:79–83. [PubMed] [Google Scholar]
  2. Bohus B., De Wied D. Inhibitory and facilitatory effect of two related peptides on extinction of avoidance behavior. Science. 1966 Jul 15;153(3733):318–320. doi: 10.1126/science.153.3733.318. [DOI] [PubMed] [Google Scholar]
  3. CLARK F. C., STEELE B. J. SOME OBSERVATIONS ON THE INTERACTION OF CHLORPROMAZINE AND FREE OPERANT AVOIDANCE BURSTS. Psychopharmacologia. 1963 May 15;4:221–231. doi: 10.1007/BF02584092. [DOI] [PubMed] [Google Scholar]
  4. ENGEL F. L., FREDERICKS J., LOPEZ E., ALBERTSON T. Some extra-adrenal actions of corticotropin on carbohydrate metabolism in the rat. Endocrinology. 1958 Dec;63(6):768–777. [PubMed] [Google Scholar]
  5. FORTIER C., DE GROOT J., HARTFIELD J. E. Plasma free corticosteroid response to faradic stimulation in the rat. Acta Endocrinol (Copenh) 1959 Feb;30(2):219–221. doi: 10.1530/acta.0.0300219. [DOI] [PubMed] [Google Scholar]
  6. GLICK D., VONREDLICH D., LEVINE S. FLUOROMETRIC DETERMINATION OF CORTICOSTERONE AND CORTISOL IN 0.02-0.05 MILLILITERS OF PLASMA OR SUBMILLIGRAM SAMPLES OF ADRENAL TISSUE. Endocrinology. 1964 Apr;74:653–655. doi: 10.1210/endo-74-4-653. [DOI] [PubMed] [Google Scholar]
  7. Glick D., Nakane P. K., Levine S., Jones L. Influence of ACTH, food restriction and electric shock on total vitamin A in the rat adrenal gland and on its quantitative histological distribution. Endocrinology. 1966 May;78(5):945–949. doi: 10.1210/endo-78-5-945. [DOI] [PubMed] [Google Scholar]
  8. HEDNER P., RERUP C. Plasma corticosteroid levels and adrenal ascorbic acid after intravenous corticotrophin injections and "stressful" stimuli in the rat. Acta Endocrinol (Copenh) 1962 Apr;39:527–538. doi: 10.1530/acta.0.0390527. [DOI] [PubMed] [Google Scholar]
  9. HODGES J. R., JONES M. T. The effect of injected corticosterone on the release of adrenocorticotrophic hormone in rats exposed to acute stress. J Physiol. 1963 Jun;167:30–37. doi: 10.1113/jphysiol.1963.sp007131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jones M. T., Stockham M. A. The effect of previous stimulation of the adrenal cortex by adrenocorticotrophin on the function of the pituitary-adrenocortical axis in response to stress. J Physiol. 1966 Jun;184(3):741–750. doi: 10.1113/jphysiol.1966.sp007945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LEIDERMAN P. H., SHAPIRO D. Application of a time series statistic to physiology and psychology. Science. 1962 Oct 12;138(3537):141–142. doi: 10.1126/science.138.3537.141. [DOI] [PubMed] [Google Scholar]
  12. LEVINE S., JONES L. E. ADRENOCORTICOTROPIC HORMONE (ACTH) AND PASSIVE AVOIDANCE LEARNING. J Comp Physiol Psychol. 1965 Jun;59:357–360. doi: 10.1037/h0022032. [DOI] [PubMed] [Google Scholar]
  13. MASON J. W., BRADY J. V., SIDMAN M. Plasma 17-hydroxycorticosteroid levels and conditioned behavior in the Rhesus monkey. Endocrinology. 1957 Jun;60(6):741–752. doi: 10.1210/endo-60-6-741. [DOI] [PubMed] [Google Scholar]
  14. MILLER R. E., OGAWA N. The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the adrenalectomized rat. J Comp Physiol Psychol. 1962 Apr;55:211–213. doi: 10.1037/h0044611. [DOI] [PubMed] [Google Scholar]
  15. MURPHY J. V., MILLER R. E. The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the rat. J Comp Physiol Psychol. 1955 Feb;48(1):47–49. doi: 10.1037/h0043004. [DOI] [PubMed] [Google Scholar]
  16. SIDMAN M. Avoidance conditioning with brief shock and no exteroceptive warning signal. Science. 1953 Aug 7;118(3058):157–158. doi: 10.1126/science.118.3058.157. [DOI] [PubMed] [Google Scholar]
  17. SIDMAN M., MASON J. W., BRADY J. V., THACH J., Jr Quantitative relations between avoidance behavior and pituitary-adrenal cortical activity. J Exp Anal Behav. 1962 Jul;5:353–362. doi: 10.1901/jeab.1962.5-353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SMELIK P. G. FAILURE TO INHIBIT CORTICOTROPHIN SECRETION BY EXPERIMENTALLY INDUCED INCREASES IN CORTICOID LEVELS. Acta Endocrinol (Copenh) 1963 Sep;44:36–46. doi: 10.1530/acta.0.0440036. [DOI] [PubMed] [Google Scholar]
  19. STOCKHAM M. A. CHANGES OF PLASMA AND ADRENAL CORTICOSTERONE LEVELS IN THE RAT AFTER REPEATED STIMULI. J Physiol. 1964 Sep;173:149–159. doi: 10.1113/jphysiol.1964.sp007448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WERTHEIM G. A. SOME SEQUENTIAL ASPECTS OF IRTS EMITTED DURING SIDMAN-AVOIDANCE BEHAVIOR IN THE WHITE RAT. J Exp Anal Behav. 1965 Jan;8:9–15. doi: 10.1901/jeab.1965.8-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. de Wied D. Inhibitory effect of ACTH and related peptides on extinction of conditioned avoidance behavior in rats. Proc Soc Exp Biol Med. 1966 May;122(1):28–32. doi: 10.3181/00379727-122-31042. [DOI] [PubMed] [Google Scholar]

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