Abstract
A swivel was developed for concurrent intraorganismic fluid injection and intracranial electrical stimulation of the unrestrained rat. Effects of various intragastric injections on bar-pressing maintained by electrical stimulation of the hypothalamus were studied. In some subjects, intragastric injections of either water or milk decreased the rate of responding. This decrease resulted from pauses in responding rather than from decreases in the local rates of responding. The decrement in responding occurred at a lower gastric volume during milk injection than during water injection. In other subjects, however, neither water, milk, nor 32% sucrose injections affected the rate of self-stimulation.
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Selected References
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- ANAND B. K., CHHINA G. S., SHARMA K. N., DUA S., SINGH B. ACTIVITY OF SINGLE NEURONS IN THE HYPOTHALAMIC FEEDING CENTERS: EFFECT OF GLUCOSE. Am J Physiol. 1964 Nov;207:1146–1154. doi: 10.1152/ajplegacy.1964.207.5.1146. [DOI] [PubMed] [Google Scholar]
 - ANAND B. K., CHHINA G. S., SINGH B. Effect of glucose on the activity of hypothalamic "feeding centers". Science. 1962 Nov 2;138(3540):597–598. doi: 10.1126/science.138.3540.597. [DOI] [PubMed] [Google Scholar]
 - ANAND B. K., DUA S., SINGH B. Electrical activity of the hypothalamic 'feeding centres' under the effect of changes in blood chemistry. Electroencephalogr Clin Neurophysiol. 1961 Feb;13:54–59. doi: 10.1016/0013-4694(61)90074-8. [DOI] [PubMed] [Google Scholar]
 - BRADY J. V., BOREN J. J., CONRAD D., SIDMAN M. The effect of food and water deprivation upon intracranial self-stimulation. J Comp Physiol Psychol. 1957 Apr;50(2):134–137. doi: 10.1037/h0045231. [DOI] [PubMed] [Google Scholar]
 - DEBOLD R. C., MILLER N. E., JENSEN D. D. EFFECT OF STRENGTH OF DRIVE DETERMINED BY A NEW TECHNIQUE FOR APPETITIVE CLASSICAL CONDITIONING OF RATS. J Comp Physiol Psychol. 1965 Feb;59:102–108. doi: 10.1037/h0021632. [DOI] [PubMed] [Google Scholar]
 - HILL J. H., STELLAR E. An electronic drinkometer. Science. 1951 Jul 13;114(2950):43–44. doi: 10.1126/science.114.2950.43. [DOI] [PubMed] [Google Scholar]
 - HODOS W., VALENSTEIN E. S. Motivational variables affecting the rate of behavior maintained by intracranial stimulation. J Comp Physiol Psychol. 1960 Oct;53:502–508. doi: 10.1037/h0043527. [DOI] [PubMed] [Google Scholar]
 - HOEBEL B. G., TEITELBAUM P. Hypothalamic control of feeding and self-stimulation. Science. 1962 Feb 2;135(3501):375–377. doi: 10.1126/science.135.3501.375. [DOI] [PubMed] [Google Scholar]
 - Johnson R. N., Trehub A., Pietskowski E. An easily-constructed cable swivel device for brain stimulation experiments. J Exp Anal Behav. 1966 Jan;9(1):17–18. doi: 10.1901/jeab.1966.9-17. [DOI] [PMC free article] [PubMed] [Google Scholar]
 - OLDS J. Effects of hunger and male sex hormone on self-stimulation of the brain. J Comp Physiol Psychol. 1958 Jun;51(3):320–324. doi: 10.1037/h0040783. [DOI] [PubMed] [Google Scholar]
 - OLDS J. Hypothalamic substrates of reward. Physiol Rev. 1962 Oct;42:554–604. doi: 10.1152/physrev.1962.42.4.554. [DOI] [PubMed] [Google Scholar]
 - OLDS J. Satiation effects in self-stimulation of the brain. J Comp Physiol Psychol. 1958 Dec;51(6):675–678. doi: 10.1037/h0039616. [DOI] [PubMed] [Google Scholar]
 - OOMURA Y., KIMURA K., OOYAMA H., MAENO T., IKI M., KUNIYOSHI M. RECIPROCAL ACTIVITIES OF THE VENTROMEDIAL AND LATERAL HYPOTHALAMIC AREAS OF CATS. Science. 1964 Jan 31;143(3605):484–485. doi: 10.1126/science.143.3605.484. [DOI] [PubMed] [Google Scholar]
 - PAINTAL A. S. A study of gastric stretch receptors; their role in the peripheral mechanism of satiation of hunger and thirst. J Physiol. 1954 Nov 29;126(2):255–270. doi: 10.1113/jphysiol.1954.sp005207. [DOI] [PMC free article] [PubMed] [Google Scholar]
 - Prescott R. G. Estrous cycle in the rat: effects on self-stimulation behavior. Science. 1966 May 6;152(3723):796–797. doi: 10.1126/science.152.3723.796. [DOI] [PubMed] [Google Scholar]
 - SHARMA K. N., ANAND B. K., DUA S., SINGH B. Role of stomach in regulation of activities of hypothalamic feeding centers. Am J Physiol. 1961 Oct;201:593–598. doi: 10.1152/ajplegacy.1961.201.4.593. [DOI] [PubMed] [Google Scholar]
 - STRICKER E. M., MILLER N. E. THIRST MEASURED BY LICKING REINFORCED ON INTERVAL SCHEDULES: EFFECTS OF PREWATERING AND OF BACTERIAL ENDOTOXIN. J Comp Physiol Psychol. 1965 Feb;59:112–115. doi: 10.1037/h0021629. [DOI] [PubMed] [Google Scholar]
 - VALENSTEIN E. S., BEER B. Reinforcing brain stimulation in competition with water reward and shock avoidance. Science. 1962 Sep 28;137(3535):1052–1054. doi: 10.1126/science.137.3535.1052. [DOI] [PubMed] [Google Scholar]
 - WEEKS J. R., DAVIS J. D. CHRONIC INTRAVENOUS CANNULAS FOR RATS. J Appl Physiol. 1964 May;19:540–541. doi: 10.1152/jappl.1964.19.3.540. [DOI] [PubMed] [Google Scholar]
 
