Abstract
Thirteen non-diabetic renal transplant recipients had various aspects of carbohydrate and lipid metabolism studied before and after conversion from cyclosporin A to azathioprine. No patient had a glucose tolerance test result diagnostic of diabetes mellitus before conversion, and there was no change in fasting glucose or immunoreactive insulin values after conversion. There was, however, a fall in the area under the curve of the glucose tolerance test values after conversion. Furthermore, fasting serum cholesterol and triglyceride concentrations fell significantly after conversion. No change in the concentration of high density lipoprotein cholesterol was detected. These findings suggest that cyclosporin A is associated with an inferior lipid profile as compared with azathioprine, which may be important in patients with transplants given the drug long term.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Calne R. Y. Cyclosporin. Nephron. 1980;26(2):57–63. doi: 10.1159/000181952. [DOI] [PubMed] [Google Scholar]
- Chan M. K., Varghese Z., Moorhead J. F. Lipid abnormalities in uremia, dialysis, and transplantation. Kidney Int. 1981 May;19(5):625–637. doi: 10.1038/ki.1981.62. [DOI] [PubMed] [Google Scholar]
- Gunnarsson R., Klintmalm G., Lundgren G., Wilczek H., Ostman J., Groth C. G. Deterioration in glucose metabolism in pancreatic transplant recipients given cyclosporin. Lancet. 1983 Sep 3;2(8349):571–572. doi: 10.1016/s0140-6736(83)90598-6. [DOI] [PubMed] [Google Scholar]
- Ost L. Effects of cyclosporin on prednisolone metabolism. Lancet. 1984 Feb 25;1(8374):451–451. doi: 10.1016/s0140-6736(84)91778-1. [DOI] [PubMed] [Google Scholar]
- Turgan C., Russell G. I., Baker F., Walls J. The effect of renal transplantation with a minimal steroid regime on uraemic hypertriglyceridaemia. Q J Med. 1984 Spring;53(210):271–277. [PubMed] [Google Scholar]