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. 2026 Jul 13;17:1837646. doi: 10.3389/fimmu.2026.1837646

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Copyright © 2026 Chan, Liang, Flisikowska, Ebner and Flisikowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Six-panel figure displays bar graphs with dot plots comparing mRNA relative levels of genes CCL2, FCGR3A, ITGAM, C1QA, C1QB, and C1QC between NM and Polyp samples for two genotypes, APC1311/+ and APC1311/+/TP53-/-, indicated by blue and brown circles. Statistically significant differences are marked by asterisks above the bars. — qPCR analysis of macrophage- and complement-related genes ((a) CCL2, (b) FCGR3A, (c) ITGAM, (d) C1QA, (e) C1QB, f. C1QC) in normal mucosa and polyp from APC^1311/+ (blue dots) and APC^1311/+/TP53^-/- (orange dots) pigs. The Independent Samples t-test was used for normally distributed data, while the Mann-Whitney U test was applied for non-normally distributed data. Data are presented as mean ± SEM (n = 4–16 pigs, 1–3 polyps were selected for qPCR from each pig); ^* means P < 0.05, ^** means P < 0.01, ^*** means P < 0.001.