Abstract
De novo synthesis in the central nervous system of IgG antibodies to human T cell lymphotropic virus type III (HTLV-III) (lymphadenopathy associated virus) was shown in seven of 10 seropositive men who had syphilis but not the acquired immune deficiency syndrome (AIDS) or AIDS related complex. None of these men showed neurological symptoms when the serum and cerebrospinal fluid were collected. Pleocytosis was present in all 10. Of the seven men who showed evidence of intrathecal synthesis of antibodies, five had increased total concentrations of IgG and four had oligoclonal IgG bands in their cerebrospinal fluid. Oligoclonal bands were also present in one man who did not have any antibodies. Longitudinal study of one man showed that seroconversion preceded intrathecal synthesis of antibody specific to HTLV-III. The appearance of antibody in the cerebrospinal fluid was accompanied by a transient rise in mononuclear cell count and the appearance of oligoclonal bands. The presence of clones of B cells specific to HTLV-III in the central nervous system of these patients without persisting neurological symptoms suggests that HTLV-III enters the central nervous system in the early stages of infection.
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- Griffin D. E., Narayan O., Bukowski J. F., Adams R. J., Cohen S. R. The cerebrospinal fluid in visna, a slow viral disease of sheep. Ann Neurol. 1978 Sep;4(3):212–218. doi: 10.1002/ana.410040304. [DOI] [PubMed] [Google Scholar]
- Hische E. A., van Meegen M. T., van der Helm H. J. More precise determination of the cerebrospinal fluid IgG index. Clin Chem. 1985 Aug;31(8):1417–1417. [PubMed] [Google Scholar]
- Klapper P. E., Laing I., Longson M. Rapid non-invasive diagnosis of herpes encephalitis. Lancet. 1981 Sep 19;2(8247):607–609. doi: 10.1016/s0140-6736(81)92744-6. [DOI] [PubMed] [Google Scholar]
- Lefvert A. K., Link H. IgG production within the central nervous system: a critical review of proposed formulae. Ann Neurol. 1985 Jan;17(1):13–20. doi: 10.1002/ana.410170105. [DOI] [PubMed] [Google Scholar]
- Martínez-Martín P., García-Sáiz A., Rapún J. L., Echevarría J. M. Intrathecal synthesis of IgG antibodies to varicella-zoster virus in two cases of acute aseptic meningitis syndrome with no cutaneous lesions. J Med Virol. 1985 Jun;16(2):201–209. doi: 10.1002/jmv.1890160213. [DOI] [PubMed] [Google Scholar]
- Pétursson G., Nathanson N., Georgsson G., Panitch H., Pálsson P. A. Pathogenesis of visna. I. Sequential virologic, serologic, and pathologic studies. Lab Invest. 1976 Oct;35(4):402–412. [PubMed] [Google Scholar]
- Resnick L., diMarzo-Veronese F., Schüpbach J., Tourtellotte W. W., Ho D. D., Müller F., Shapshak P., Vogt M., Groopman J. E., Markham P. D. Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex. N Engl J Med. 1985 Dec 12;313(24):1498–1504. doi: 10.1056/NEJM198512123132402. [DOI] [PubMed] [Google Scholar]
- Shaw G. M., Harper M. E., Hahn B. H., Epstein L. G., Gajdusek D. C., Price R. W., Navia B. A., Petito C. K., O'Hara C. J., Groopman J. E. HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science. 1985 Jan 11;227(4683):177–182. doi: 10.1126/science.2981429. [DOI] [PubMed] [Google Scholar]
- Tibbling G., Link H., Ohman S. Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand J Clin Lab Invest. 1977 Sep;37(5):385–390. doi: 10.1080/00365517709091496. [DOI] [PubMed] [Google Scholar]
- van der Helm H. J., Hische E. A., van Walbeek H. K. Monoclonal immunoglobulins demonstrable in cerebrospinal fluid by use of cellulose acetate electrophoresis. Clin Chem. 1980 Dec;26(13):1917–1918. [PubMed] [Google Scholar]