Abstract
A relation between the prevalence of asthma and economic development has been suggested by studies in migrants and other surveys in developing countries. That this correlation might be partially explained by an increased intake of salt in the diet is supported by the observation that sales of table salt in the different regions of England and Wales are independently correlated with mortality from asthma for men and for children. As part of a wider survey of asthma 138 men living in two Hampshire villages and aged 18-64 were given a bronchial histamine challenge test and had their 24 hour urinary excretion of sodium measured. Bronchial reactivity was strongly related to 24 hour excretion of sodium after allowing for the effects of age, atopy, and cigarette smoking, there being on average a 10-fold difference in reactivity over the 95% range of sodium excretion recorded in the study. The data suggest that a high sodium diet may potentiate bronchial reactivity.
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Selected References
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- Anderson H. R. Respiratory abnormalities in Papua New Guinea children: the effects of locality and domestic wood smoke pollution. Int J Epidemiol. 1978 Mar;7(1):63–72. doi: 10.1093/ije/7.1.63. [DOI] [PubMed] [Google Scholar]
- Bock S. A., Buckley J., Holst A., May C. D. Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children. Clin Allergy. 1977 Jul;7(4):375–383. doi: 10.1111/j.1365-2222.1977.tb01466.x. [DOI] [PubMed] [Google Scholar]
- Dehaut P., Rachiele A., Martin R. R., Malo J. L. Histamine dose-response curves in asthma: reproducibility and sensitivity of different indices to assess response. Thorax. 1983 Jul;38(7):516–522. doi: 10.1136/thx.38.7.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Godfrey R. C. Asthma and IgE levels in rural and urban communities of The Gambia. Clin Allergy. 1975 Jun;5(2):201–207. doi: 10.1111/j.1365-2222.1975.tb01853.x. [DOI] [PubMed] [Google Scholar]
- Liu K., Cooper R., McKeever J., McKeever P., Byington R., Soltero I., Stamler R., Gosch F., Stevens E., Stamler J. Assessment of the association between habitual salt intake and high blood pressure: methodological problems. Am J Epidemiol. 1979 Aug;110(2):219–226. doi: 10.1093/oxfordjournals.aje.a112806. [DOI] [PubMed] [Google Scholar]
- Souhrada M., Souhrada J. F. Immunologically induced alterations of airway smooth muscle cell membrane. Science. 1984 Aug 17;225(4663):723–725. doi: 10.1126/science.6087455. [DOI] [PubMed] [Google Scholar]
- Van Niekerk C. H., Weinberg E. G., Shore S. C., Heese H. V., Van Schalkwyk J. Prevalence of asthma: a comparative study of urban and rural Xhosa children. Clin Allergy. 1979 Jul;9(4):319–314. doi: 10.1111/j.1365-2222.1979.tb02489.x. [DOI] [PubMed] [Google Scholar]
- Waite D. A., Eyles E. F., Tonkin S. L., O'Donnell T. V. Asthma prevalence in Tokelauan children in two environments. Clin Allergy. 1980 Jan;10(1):71–75. doi: 10.1111/j.1365-2222.1980.tb02082.x. [DOI] [PubMed] [Google Scholar]
- Yan K., Salome C., Woolcock A. J. Rapid method for measurement of bronchial responsiveness. Thorax. 1983 Oct;38(10):760–765. doi: 10.1136/thx.38.10.760. [DOI] [PMC free article] [PubMed] [Google Scholar]