Abstract
Data from 13 randomised trials on the effect of sodium restriction on blood pressure were analysed. The hypotensive effect of sodium restriction was found to be small and restricted largely to systolic blood pressure, which fell by an average of 3.6 mm Hg (range 0.5-10.0 mm Hg). The reduction increased with age and in those with higher blood pressure. Sodium restriction therefore seems to be of limited use in those who are most eligible for non-pharmacological treatment of high blood pressure--namely, young patients with mild hypertension.
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- Beard T. C., Cooke H. M., Gray W. R., Barge R. Randomised controlled trial of a no-added-sodium diet for mild hypertension. Lancet. 1982 Aug 28;2(8296):455–458. doi: 10.1016/s0140-6736(82)90491-3. [DOI] [PubMed] [Google Scholar]
- CHAPMAN C. B., GIBBONS T. B. The diet and hypertension; a review. Medicine (Baltimore) 1950 Feb;29(1):29–69. doi: 10.1097/00005792-195002000-00002. [DOI] [PubMed] [Google Scholar]
- Cooper R., Van Horn L., Liu K., Trevisan M., Nanas S., Ueshima H., Larbi E., Yu C. S., Sempos C., LeGrady D. A randomized trial on the effect of decreased dietary sodium intake on blood pressure in adolescents. J Hypertens. 1984 Aug;2(4):361–366. [PubMed] [Google Scholar]
- Erwteman T. M., Nagelkerke N., Lubsen J., Koster M., Dunning A. J. Beta blockade, diuretics, and salt restriction for the management of mild hypertension: a randomised double blind trial. Br Med J (Clin Res Ed) 1984 Aug 18;289(6442):406–409. doi: 10.1136/bmj.289.6442.406. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ilsley C. D., Millar J. A. Hypertension in children. Br Med J (Clin Res Ed) 1985 May 18;290(6480):1451–1452. doi: 10.1136/bmj.290.6480.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Longworth D. L., Drayer J. I., Weber M. A., Laragh J. H. Divergent blood pressure responses during short-term sodium restriction in hypertension. Clin Pharmacol Ther. 1980 Apr;27(4):544–546. doi: 10.1038/clpt.1980.76. [DOI] [PubMed] [Google Scholar]
- Miller J. Z., Daugherty S. A., Weinberger M. H., Grim C. E., Christian J. C., Lang C. L. Blood pressure response to dietary sodium restriction in normotensive adults. Hypertension. 1983 Sep-Oct;5(5):790–795. doi: 10.1161/01.hyp.5.5.790. [DOI] [PubMed] [Google Scholar]
- Morgan T., Adam W., Gillies A., Wilson M., Morgan G., Carney S. Hypertension treated by salt restriction. Lancet. 1978 Feb 4;1(8058):227–230. doi: 10.1016/s0140-6736(78)90479-8. [DOI] [PubMed] [Google Scholar]
- Parijs J., Joossens J. V., Van der Linden L., Verstreken G., Amery A. K. Moderate sodium restriction and diuretics in the treatment of hypertension. Am Heart J. 1973 Jan;85(1):22–34. doi: 10.1016/0002-8703(73)90522-x. [DOI] [PubMed] [Google Scholar]
- Richards A. M., Nicholls M. G., Espiner E. A., Ikram H., Maslowski A. H., Hamilton E. J., Wells J. E. Blood-pressure response to moderate sodium restriction and to potassium supplementation in mild essential hypertension. Lancet. 1984 Apr 7;1(8380):757–761. doi: 10.1016/s0140-6736(84)91276-5. [DOI] [PubMed] [Google Scholar]
- Skrabal F., Auböck J., Hörtnagl H. Low sodium/high potassium diet for prevention of hypertension: probable mechanisms of action. Lancet. 1981 Oct 24;2(8252):895–900. doi: 10.1016/s0140-6736(81)91392-1. [DOI] [PubMed] [Google Scholar]
- Watt G. C., Edwards C., Hart J. T., Hart M., Walton P., Foy C. J. Dietary sodium restriction for mild hypertension in general practice. Br Med J (Clin Res Ed) 1983 Feb 5;286(6363):432–436. doi: 10.1136/bmj.286.6363.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watt G. C., Foy C. J., Hart J. T., Bingham G., Edwards C., Hart M., Thomas E., Walton P. Dietary sodium and arterial blood pressure: evidence against genetic susceptibility. Br Med J (Clin Res Ed) 1985 Nov 30;291(6508):1525–1528. doi: 10.1136/bmj.291.6508.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]