Abstract
A new method for determining the glomerular filtration rate was analysed prospectively. The method uses an x ray fluorescence technique to measure disappearance from the plasma of injected non-ionic iodinated contrast media. Eighty seven patients were studied. Fifty four had an intravenous dose of 100 ml iohexol (Omnipaque) and 33 had 50 ml iohexol. Clearances of chromium-51 labelled edetic acid (51Cr-EDTA) were measured simultaneously. In the patients given 100 ml iohexol there was excellent correlation with 51Cr-EDTA clearance (r = 0.90). The correlation using 50 ml iohexol was also good (r = 0.85). Correlation between creatinine clearance and clearance of 51Cr-EDTA in 33 patients was less satisfactory (r = 0.69). There were no adverse reactions to the contrast media. The equipment used for measuring contrast clearance was robust and simple to operate. Freezing plasma samples in 10 studies and re-examining them weekly for six weeks showed no significant variation in results; hence reproducibility was good. This new and accurate method for determining the glomerular filtration rate merits further study and might find a useful place in routine clinical practice.
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- Fischer H. W., Morris T. W. Cardiovascular radiology. Possible factors in intravascular contrast media toxicity. Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S232–S238. doi: 10.1097/00004424-198011001-00049. [DOI] [PubMed] [Google Scholar]
- Gotsman M. S., van der Horst R. L., Winship W. S. The chest radiograph in primary myocardial disease. Radiology. 1971 Apr;99(1):1–13. doi: 10.1148/99.1.1. [DOI] [PubMed] [Google Scholar]
- Grainger R. G. Low osmolar contrast media. Br Med J (Clin Res Ed) 1984 Jul 21;289(6438):144–145. doi: 10.1136/bmj.289.6438.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grönberg T., Almén T., Golman K., Lidén K., Mattsson S., Sjöberg S. Non-invasive estimation of kidney function by x-ray fluorescence analysis. Method for in vivo measurements of iodine-containing contrast media in rabbits. Phys Med Biol. 1981 May;26(3):501–506. doi: 10.1088/0031-9155/26/3/012. [DOI] [PubMed] [Google Scholar]
- Imamura K., Sasaki Y., Sekita N., Someya K., Fujii M. Quantitative in vivo measurement of thyroidal iodine content by static x-ray fluorescent technique: some preliminary clinical observations. Invest Radiol. 1979 Jul-Aug;14(4):316–322. doi: 10.1097/00004424-197907000-00009. [DOI] [PubMed] [Google Scholar]
- Kaufman L., Shames D. M., Greenspan R. H., Powell M. R., Perez-Mendez V. Cardiac output determination by fluorescence excitation in the dog. Invest Radiol. 1972 Sep-Oct;7(5):365–368. doi: 10.1097/00004424-197209000-00002. [DOI] [PubMed] [Google Scholar]
- Low osmolar contrast media. Br Med J (Clin Res Ed) 1984 Aug 11;289(6441):379–380. doi: 10.1136/bmj.289.6441.379-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phelps M. E., Grubb R. L., Jr, Ter-Pogossian M. M. In vivo regional cerebral blood volume by x-ray fluorescence: validation of method. J Appl Physiol. 1973 Nov;35(5):741–747. doi: 10.1152/jappl.1973.35.5.741. [DOI] [PubMed] [Google Scholar]