Abstract
Alcohol abuse leads to impotence, infertility, and feminisation. Patients with chronic alcoholism may have impaired hypothalamic-pituitary function. The release of luteinising hormone was investigated in men with alcoholic cirrhosis with and without hypogonadism and controls. Blood was sampled every 15 minutes for six or eight hours and luteinising hormone concentrations measured by radioimmunoassay. Data were analysed by iterative computerised analysis and spectral analysis to assess pulsatile release and the length of the cycle, respectively. Pulsatile release of luteinising hormone was shown in all the control subjects; in the men with alcoholic liver disease it was normal in those with subclinical primary testicular failure but absent or grossly attenuated in those with overt combined central and primary gonadal failure. The impaired release of luteinising hormone in the men with overt gonadal failure might be due to a hypothalamic defect.
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Selected References
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- Bannister P., Sheridan P., Losowsky M. S. Plasma concentrations of sex hormones in postmenopausal women in non-alcoholic cirrhosis. Clin Endocrinol (Oxf) 1985 Oct;23(4):335–340. doi: 10.1111/j.1365-2265.1985.tb01089.x. [DOI] [PubMed] [Google Scholar]
- Boyden T. W., Pamenter R. W. Effects of ethanol on the male hypothalamic-pituitary-gonadal axis. Endocr Rev. 1983 Fall;4(4):389–395. doi: 10.1210/edrv-4-4-389. [DOI] [PubMed] [Google Scholar]
- Clifton D. K., Steiner R. A. Cycle detection: a technique for estimating the frequency and amplitude of episodic fluctuations in blood hormone and substrate concentrations. Endocrinology. 1983 Mar;112(3):1057–1064. doi: 10.1210/endo-112-3-1057. [DOI] [PubMed] [Google Scholar]
- Murdoch A. P., Diggle P. J., Dunlop W., Kendall-Taylor P. Determination of the frequency of pulsatile luteinizing hormone secretion by time series analysis. Clin Endocrinol (Oxf) 1985 Mar;22(3):341–346. doi: 10.1111/j.1365-2265.1985.tb03246.x. [DOI] [PubMed] [Google Scholar]
- Rodger R. S., Morrison L., Dewar J. H., Wilkinson R., Ward M. K., Kerr D. N. Loss of pulsatile luteinising hormone secretion in men with chronic renal failure. Br Med J (Clin Res Ed) 1985 Dec 7;291(6509):1598–1600. doi: 10.1136/bmj.291.6509.1598. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Thiel D. H., Lester R., Sherins R. J. Hypogonadism in alcoholic liver disease: evidence for a double defect. Gastroenterology. 1974 Dec;67(6):1188–1199. [PubMed] [Google Scholar]
- Van Thiel D. H., Lester R., Vaitukaitis J. Evidence for a defect in pituitary secretion of luteinizing hormone in chronic alcoholic men. J Clin Endocrinol Metab. 1978 Sep;47(3):499–507. doi: 10.1210/jcem-47-3-499. [DOI] [PubMed] [Google Scholar]
- Winters S. J., Troen P. A reexamination of pulsatile luteinizing hormone secretion in primary testicular failure. J Clin Endocrinol Metab. 1983 Aug;57(2):432–435. doi: 10.1210/jcem-57-2-432. [DOI] [PubMed] [Google Scholar]
- Winters S. J., Troen P. Altered pulsatile secretion of luteinizing hormone in hypogonadal men with hyperprolactinaemia. Clin Endocrinol (Oxf) 1984 Sep;21(3):257–263. doi: 10.1111/j.1365-2265.1984.tb03467.x. [DOI] [PubMed] [Google Scholar]