Abstract
Seven patients with active acromegaly were treated with SMS 201-995, an analogue of somatostatin, for one year, the maximum dose being 100 micrograms three times a day. Three patients had impaired glucose tolerance before treatment, due to insulin resistance in two and insulin deficiency in one. In all patients treatment with the analogue slightly increased postprandial glucose concentrations and suppressed insulin concentrations for two to two and a half hours after each injection; growth hormone concentrations decreased progressively with treatment. The patient with impaired glucose tolerance due to insulin deficiency developed diabetes mellitus after four months' treatment; concomitant treatment with glibenclamide resulted in a decreased glucose concentration and increased insulin concentration. This analogue of somatostatin had only minor side effects on glucose tolerance in patients with acromegaly and may be used in patients with impaired glucose tolerance provided that glucose concentrations are monitored closely.
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Selected References
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- Bauer W., Briner U., Doepfner W., Haller R., Huguenin R., Marbach P., Petcher T. J., Pless SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci. 1982 Sep 13;31(11):1133–1140. doi: 10.1016/0024-3205(82)90087-x. [DOI] [PubMed] [Google Scholar]
- Ch'ng L. J., Sandler L. M., Kraenzlin M. E., Burrin J. M., Joplin G. F., Bloom S. R. Long term treatment of acromegaly with a long acting analogue of somatostatin. Br Med J (Clin Res Ed) 1985 Jan 26;290(6464):284–285. doi: 10.1136/bmj.290.6464.284-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coraggio F., Scarpato P., Spina M., Lombardi S. Somatostatin and ranitidine in the control of iatrogenic haemorrhage of the upper gastrointestinal tract. Br Med J (Clin Res Ed) 1984 Jul 28;289(6439):224–224. doi: 10.1136/bmj.289.6439.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heij H. A., Bruining H. A., Verschoor L. A comparison of the effects of two somatostatin analogues in a patient with an external pancreatic fistula. Pancreas. 1986;1(2):188–190. doi: 10.1097/00006676-198603000-00014. [DOI] [PubMed] [Google Scholar]