Skip to main content
Journal of Accident & Emergency Medicine logoLink to Journal of Accident & Emergency Medicine
. 1997 Jul;14(4):259–261. doi: 10.1136/emj.14.4.259

Gamma hydroxybutyrate--a coma inducing recreational drug.

J M Ryan 1, I Stell 1
PMCID: PMC1342956  PMID: 9248920

Abstract

The effects of gamma hydroxybutyrate, a coma inducing recreational drug, are described and illustrated by case reports of five patients presenting to accident and emergency (A&E). All had depressed levels of consciousness. There was strong circumstantial evidence of gamma hydroxybutyrate ingestion in all cases, and laboratory evidence in two. All recovered and supportive treatment. gamma Hydroxybutyrate has become a fashionable recreational drug. The majority of people who have ingested it will recover spontaneously without long term sequelae but its toxic effects may be dramatic while they last, particularly when it is taken with other drugs or alcohol.

Full text

PDF
259

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chin M. Y., Kreutzer R. A., Dyer J. E. Acute poisoning from gamma-hydroxybutyrate in California. West J Med. 1992 Apr;156(4):380–384. [PMC free article] [PubMed] [Google Scholar]
  2. Ferrara S. D., Tedeschi L., Frison G., Rossi A. Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication. J Forensic Sci. 1995 May;40(3):501–504. [PubMed] [Google Scholar]
  3. Gallimberti L., Canton G., Gentile N., Ferri M., Cibin M., Ferrara S. D., Fadda F., Gessa G. L. Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Lancet. 1989 Sep 30;2(8666):787–789. doi: 10.1016/s0140-6736(89)90842-8. [DOI] [PubMed] [Google Scholar]
  4. Galloway G. P., Frederick S. L., Staggers F., Jr Physical dependence on sodium oxybate. Lancet. 1994 Jan 1;343(8888):57–57. doi: 10.1016/s0140-6736(94)90911-3. [DOI] [PubMed] [Google Scholar]
  5. Palatini P., Tedeschi L., Frison G., Padrini R., Zordan R., Orlando R., Gallimberti L., Gessa G. L., Ferrara S. D. Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers. Eur J Clin Pharmacol. 1993;45(4):353–356. doi: 10.1007/BF00265954. [DOI] [PubMed] [Google Scholar]
  6. Vickers M. D. Gammahydroxybutyric acid. Int Anesthesiol Clin. 1969 Spring;7(1):75–89. doi: 10.1097/00004311-196900710-00007. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Accident & Emergency Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES