Abstract
OBJECTIVES: To compare two activated charcoal preparations (Carbomix and Actidose-Aqua) in terms of amount ingested and incidence of vomiting after ingestion. METHODS: Single blinded prospective randomised controlled trial. RESULTS: The mean amount of charcoal ingested was Carbomix 26.5 g, Actidose-Aqua 19.5 g. The mean difference was 7 g (95% confidence interval (CI) 1.5 to 12.4 g). The incidence of vomiting was for the Carbomix 6% and the Actidose-Aqua 8%. The mean difference in vomiting was 2% (95% CI -0.8 to 4.8) CONCLUSIONS: Carbomix administration results in an increased amount of activated charcoal ingested after oral administration. Rates of vomiting after activated charcoal administration were low when compared with previously reported rates.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chin L., Picchioni A. L., Bourn W. M., Laird H. E. Optimal antidotal dose of activated charcoal. Toxicol Appl Pharmacol. 1973 Sep;26(1):103–108. doi: 10.1016/0041-008x(73)90090-2. [DOI] [PubMed] [Google Scholar]
- Donovan J. W. Activated charcoal in management of poisoning. A revitalized antidote. Postgrad Med. 1987 Jul;82(1):52–59. doi: 10.1080/00325481.1987.11699893. [DOI] [PubMed] [Google Scholar]
- Henry J. A., Hoffman J. R. Continuing controversy on gut decontamination. Lancet. 1998 Aug 8;352(9126):420–421. doi: 10.1016/S0140-6736(05)79183-2. [DOI] [PubMed] [Google Scholar]
- McFarland A. K., 3rd, Chyka P. A. Selection of activated charcoal products for the treatment of poisonings. Ann Pharmacother. 1993 Mar;27(3):358–361. doi: 10.1177/106002809302700320. [DOI] [PubMed] [Google Scholar]
- Neuvonen P. J., Vartiainen M., Tokola O. Comparison of activated charcoal and ipecac syrup in prevention of drug absorption. Eur J Clin Pharmacol. 1983;24(4):557–562. doi: 10.1007/BF00609903. [DOI] [PubMed] [Google Scholar]