Abstract
A 25 year old man presented with anuria and bilateral leg pain two days after an alcoholic binge. He subsequently developed rhabdomyolysis causing acute renal failure, with compartment syndrome of both lower legs. This required urgent dialysis and fasciotomy respectively within six hours of admission. He remained dialysis dependent for three weeks and only after four months was he able to weight bear on both legs. Alcohol is a leading cause of rhabdomyolysis. Early recognition and prompt treatment is essential to prevent serious complications.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Better O. S., Stein J. H. Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. N Engl J Med. 1990 Mar 22;322(12):825–829. doi: 10.1056/NEJM199003223221207. [DOI] [PubMed] [Google Scholar]
- Bourne R. B., Rorabeck C. H. Compartment syndromes of the lower leg. Clin Orthop Relat Res. 1989 Mar;(240):97–104. [PubMed] [Google Scholar]
- Curry S. C., Chang D., Connor D. Drug- and toxin-induced rhabdomyolysis. Ann Emerg Med. 1989 Oct;18(10):1068–1084. doi: 10.1016/s0196-0644(89)80933-3. [DOI] [PubMed] [Google Scholar]
- Haller R. G., Knochel J. P. Skeletal muscle disease in alcoholism. Med Clin North Am. 1984 Jan;68(1):91–103. doi: 10.1016/s0025-7125(16)31243-3. [DOI] [PubMed] [Google Scholar]
- Köppel C. Clinical features, pathogenesis and management of drug-induced rhabdomyolysis. Med Toxicol Adverse Drug Exp. 1989 Mar-Apr;4(2):108–126. doi: 10.1007/BF03259907. [DOI] [PubMed] [Google Scholar]
- Zager R. A. Combined mannitol and deferoxamine therapy for myohemoglobinuric renal injury and oxidant tubular stress. Mechanistic and therapeutic implications. J Clin Invest. 1992 Sep;90(3):711–719. doi: 10.1172/JCI115942. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zager R. A., Mahan J., Merola A. J. Effects of mannitol on the postischemic kidney. Biochemical, functional, and morphologic assessments. Lab Invest. 1985 Oct;53(4):433–442. [PubMed] [Google Scholar]