Abstract
A multidiscipline group was established at The Pennsylvania State University to design and evaluate mechanical circulatory assist devices and the artificial heart. The group has designed a left ventricular to aortic assist system which consists of a sac-type pump, a synchronization unit, a pneumatic power unit, and appropriate monitoring apparatus. The assist system has been evaluated for long-term circulatory assistance in a series of ten calves. The assist pump was placed in the paracorporeal position. The longest period of continuous pumping was over eight months. The last four calves have had synchronized assist pumping which has permitted prolonged ventricular decompression and assist pump flow rates as high as 10 L/min. Three of these four calves had no evidence of thromboemboli. Additional animal studies will be required before clinical use of such an assist pump system can be safely undertaken.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boretos J. W., Pierce W. S. Segmented polyurethane: a new elastomer for biomedical applications. Science. 1967 Dec 15;158(3807):1481–1482. doi: 10.1126/science.158.3807.1481. [DOI] [PubMed] [Google Scholar]
- Boretos J. W. Tissue pathology and physical stability of a polyether elastomer on three-year implantation. J Biomed Mater Res. 1972 Sep;6(5):473–476. doi: 10.1002/jbm.820060513. [DOI] [PubMed] [Google Scholar]
- DeBakey M. E. Left ventricular bypass pump for cardiac assistance. Clinical experience. Am J Cardiol. 1971 Jan;27(1):3–11. doi: 10.1016/0002-9149(71)90076-2. [DOI] [PubMed] [Google Scholar]
- Neely J. R., Liebermeister H., Battersby E. J., Morgan H. E. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol. 1967 Apr;212(4):804–814. doi: 10.1152/ajplegacy.1967.212.4.804. [DOI] [PubMed] [Google Scholar]
- Pierce W. S., Aaronson A. E., Prophet G. A., Williams D. R., Waldhausen J. A. Hemodynamic and metabolic studies during two types of left ventricular bypass. Surg Forum. 1972;23(0):176–178. [PubMed] [Google Scholar]
- Pierce W. S., Brighton J. A., O'Bannon W., Phillips W. M., Landis D. L., White W. J., Prophet G. A., Waldhausen J. A. Prolonged left ventricle-to-aorta pumping with left ventricular decompression using a paracorporeal pump: experimental study in the calf. Surg Forum. 1973;24:156–158. [PubMed] [Google Scholar]
- Robinson W. J., Migliore J. J., Arthur J., Fuqua J. M., Dove G. B., Coleman S., Huffman F. N., Norman J. C. An abdominal left ventricular assist device: experimental physiologic analyses. II. Trans Am Soc Artif Intern Organs. 1973;19:229–234. doi: 10.1097/00002480-197301900-00039. [DOI] [PubMed] [Google Scholar]
- Wilmore D. W., Dudrick S. J. Safe long-term venous catheterization. Arch Surg. 1969 Feb;98(2):256–258. doi: 10.1001/archsurg.1969.01340080148035. [DOI] [PubMed] [Google Scholar]