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. 1976 Apr;183(4):409–414. doi: 10.1097/00000658-197604000-00014

Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs.

P J Wilk, R C Karipineni, D Pertsemlidis, C A Danese
PMCID: PMC1344213  PMID: 817679

Abstract

The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio-iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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