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. 1976 Jul;184(1):80–88. doi: 10.1097/00000658-197607000-00014

Fat emulsion for intravenous administration: clinical experience with intralipid 10%.

L M Hansen, B S Hardie, J Hidalgo
PMCID: PMC1344312  PMID: 820291

Abstract

A 10% soybean oil emulsion (Intralipid 10%), used extensively in Europe for intravenous alimentation, has now been clinically evaluated in the United States. Controlled studies have shown that the soybean oil emulsion can be substituted for glucose to supply one-third to two-thirds of the total calories, and can be administered peripherally without significant vein irritation. Essential fatty acid deficiencies, frequently encountered in patients dependent on parenteral alimentation with fat-free solutions, are prevented and corrected by use of this preparation. Data on long-term tolerance to Intralipid 10% infusions are presented for 292 patients treated for more than 6,000 patient days. The soybean oil emulsion was usually well tolerated. Side effects were reported in two of 133 adults and 12 of 159 pediatric patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER C. S., ZIEVE L. Fat infusions. Toxic effects and alterations in fasting serum lipids following prolonged use. Arch Intern Med. 1961 Apr;107:514–528. doi: 10.1001/archinte.1961.03620040040005. [DOI] [PubMed] [Google Scholar]
  2. ARTZ C. P. Newer concepts of nutrition by the intravenous route. Ann Surg. 1959 Jun;149(6):841–851. doi: 10.1097/00000658-195906000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Akamatsu K., Nishizaki T., Endo H., Taketa K. [A case of anorexia nervosa: improvement following intravenous administration of fat emulsion (Intralipid) combined with tube feeding]. Nihon Naika Gakkai Zasshi. 1972 Mar;61(3):274–281. doi: 10.2169/naika.61.274. [DOI] [PubMed] [Google Scholar]
  4. Borresen H. C., Coran A. G., Knutrud O. Metabolic results of parenteral feeding in neonatal surgery: a balanced parenteral feeding program based on a synthetic 1-amino acid solution and a commercial fat emulsion. Ann Surg. 1970 Aug;172(2):291–301. doi: 10.1097/00000658-197008000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chaptal J., Jean R., Crastes de Paulet A., Pages A., Dossa D., Guillaumot R., Crastes de Paulet, Robinet, Morel G., Romeu H. Perfusions d'emulsions de lipides chez le nourrisson et l'enfant. Etude clinique, biologique et anatomique. Arch Fr Pediatr. 1965 Aug-Sep;22(7):799–821. [PubMed] [Google Scholar]
  6. Coran A. G. Total intravenous feeding of infants and children without use of a central venous catheter. Ann Surg. 1974 Apr;179(4):445–449. doi: 10.1097/00000658-197404000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EDGREN B., HALLBERG D., HAKANSSON I., MENG H. C., WRETLIND A. LONG-TERM TOLERANCE STUDY OF TWO FAT EMULSIONS FOR INTRAVENOUS NUTRITION IN DOGS. Am J Clin Nutr. 1964 Jan;14:28–36. doi: 10.1093/ajcn/14.1.28. [DOI] [PubMed] [Google Scholar]
  8. HORISBERGER B. ERSTE ERFAHRUNGEN MIT EINER 20PROZENTIGEN FETTEMULSION IN DER POSTOPERATIVEN BEHANDLUNG. Helv Chir Acta. 1965 Jan;32:48–53. [PubMed] [Google Scholar]
  9. Hallberg D., Holm I., Obel A. L., Schuberth O., Wretlind A. Fat emulsions for complete intravenous nutrition. Postgrad Med J. 1967 Apr;43(498):307–316. [PMC free article] [PubMed] [Google Scholar]
  10. Hanc I., Kleczkowska H., Rodkiewicz B. Uwagi w sprawie stosowania dozylnych wlewów emulsji tłuszczowych w klinice chirurgii dzieciecej. Pediatr Pol. 1968 Nov;43(11):1355–1364. [PubMed] [Google Scholar]
  11. Jacobson S., Ericsson J. L., Obel A. L. Histopathological and ultrastructural changes in the human liver during complete intravenous nutrition for seven months. Acta Chir Scand. 1971;137(4):335–349. [PubMed] [Google Scholar]
  12. Jeejeebhoy K. N., Zohrab W. J., Langer B., Phillips M. J., Kuksis A., Anderson G. H. Total parenteral nutrition at home for 23 months, without complication, and with good rehabilitation. A study of technical and metabolic features. Gastroenterology. 1973 Nov;65(5):811–820. [PubMed] [Google Scholar]
  13. LEVENSON S. M., UPJOHN H. L., SHEEHY T. W. Two severe reactions following the long-term intrusion of large amounts of intravenous fat emulsion. Metabolism. 1957 Nov;6(6 Pt 2):807–814. [PubMed] [Google Scholar]
  14. Larsen V., Brockner J. Nitrogen balance and operative stress. Effect of early postoperative nutrition on nitrogen balance following major surgery. Acta Chir Scand Suppl. 1965;343:191–202. [PubMed] [Google Scholar]
  15. MENG H. C., KALEY J. S. EFFECTS OF MULTIPLE INFUSIONS OF A FAT EMULSION ON BLOOD COAGULATION, LIVER FUNCTION AND URINARY EXCRETION OF STEROIDS IN SCHIZOPHRENIC PATIENTS. Am J Clin Nutr. 1965 Jan;16:156–164. doi: 10.1093/ajcn/16.1.156. [DOI] [PubMed] [Google Scholar]
  16. MENG H. C., KUYAMA T., THOMPSON S. W., 2nd, FERRELL J. F. TOXICITY TESTING OF FAT EMULSIONS. I. TOLERANCE STUDY OF LONG-TERM INTRAVENOUS ADMINISTRATION OF INTRALIPID IN RATS. Am J Clin Nutr. 1965 Jan;16:29–36. doi: 10.1093/ajcn/16.1.29. [DOI] [PubMed] [Google Scholar]
  17. Reid D. J. Intravenous fat therapy. II. Changes in oxygen consumption and respiratory quotient. Br J Surg. 1967 Mar;54(3):204–207. doi: 10.1002/bjs.1800540312. [DOI] [PubMed] [Google Scholar]
  18. Reid D. J. Metabolic and blood coagulation changes during intravenous fat infusions. Ann R Coll Surg Engl. 1968 May;42(5):322–337. [PMC free article] [PubMed] [Google Scholar]
  19. Vretlind A., Shubert O., Peterson B. E., Smol'nikov V. P., Sudzhian A. V. Intralipid i aminozol kak istochniki polnotsennogo parenteral'nogo pitaniia. Eksp Khir Anesteziol. 1970 Jul-Aug;15(4):47–52. [PubMed] [Google Scholar]
  20. WATKIN D. M. Clinical, chemical, hematologic and anatomic changes accompanying repeated intravenous administration of fat emulsion to man. Metabolism. 1957 Nov;6(6 Pt 2):785–806. [PubMed] [Google Scholar]
  21. Wei P., Hamilton J. R., LeBlanc A. E. A clinical and metabolic study of an intravenous feeding technique using peripheral veins as the initial infusion site. Can Med Assoc J. 1972 May 6;106(9):969–passim. [PMC free article] [PubMed] [Google Scholar]
  22. Yeo M. T., Gazzaniga A. B., Bartlett R. H., Shobe J. B. Total intravenous nutrition. Experience with fat emulsions and hypertonic glucose. Arch Surg. 1973 Jun;106(6):792–796. doi: 10.1001/archsurg.1973.01350180032011. [DOI] [PubMed] [Google Scholar]

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