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. 1976 May;183(5):470–475. doi: 10.1097/00000658-197605000-00003

Myxoma of the heart: clinical and experimental observations.

P N Symbas, C R Hatcher Jr, M B Gravanis
PMCID: PMC1344326  PMID: 1275588

Abstract

During the past 12 years, 13 patients with atrial (10 left and 3 right) myxoma have been treated. The tumors of the left atrium produced signs and symptoms of mitral valve obstruction and/or subacute bacterial endocarditis and those of the right atrium manifestations of tricuspid valve disease or of pulmonary embolus or hypertension. The diagnosis was established by angiocardiography in 8 patients, at surgery performed for suspected mitral stenosis in 3 patients, and at autopsy in 2 patients. Resection of the atrial myxoma alone in 5 patients or with atrial septum where the atrial myxoma was attached in 4 or with the whole right atrial wall where the atrial myxoma was attached in one patient was performed and all are doing well without evidence of recurrence. Studies of experimentally produced 1.5-3 cm in diameter left atrial thrombus in 30 dogs divided into 5 groups and followed cineangiocardiographically and sacrificed from 14 days to 6 months indicated that the implanted thrombus is absorbed over a 3 to 6 month period. These experimental and human left atrial thrombi were found to be histologically and histochemically different from human atrial myxomas. The electron microscopic studies performed on some of the resected atrial myxomas suggested that the atrial myxoma cells are active cells of endotheilial origin. These observations suggest that atrial myxoma is a primary tumor of the heart which can mimic other clinical entities, and the results of its surgical treatment are gratifying and long lasting.

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471Fig. 1.
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472Figs. 3a to c.
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473Figs. 4a to d.
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABBOTT O. A., WARSHAWSKI F. E., COBBS B. W., Jr Primary tumors and pseudotumors of the heart. Ann Surg. 1962 Jun;155:855–872. doi: 10.1097/00000658-196206000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COOLEY D. A., MORRIS G. C., Jr, ATTAR S. Cardiac myxoma; surgical treatment in four cases. AMA Arch Surg. 1959 Mar;78(3):410–417. [PubMed] [Google Scholar]
  3. Emanuel R. W., Lloyd W. E. RIGHT ATRIAL MYXOMA MISTAKEN FOR CONSTRICTIVE PERICARDITIS. Br Heart J. 1962 Nov;24(6):796–800. doi: 10.1136/hrt.24.6.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FISHER E. R., HELLSTROM H. R. Evidence in support of the neoplastic nature of cardiac myxoma. Am Heart J. 1960 Oct;60:630–640. doi: 10.1016/0002-8703(60)90441-5. [DOI] [PubMed] [Google Scholar]
  5. Ferrans V. J., Roberts W. C. Structural features of cardiac myxomas. Histology, histochemistry, and electron microscopy. Hum Pathol. 1973 Mar;4(1):111–146. doi: 10.1016/s0046-8177(73)80051-6. [DOI] [PubMed] [Google Scholar]
  6. Fine G., Morales A., Horn R. C., Jr Cardiac myxoma. A morphologic and histogenetic appraisal. Cancer. 1968 Dec;22(6):1156–1162. doi: 10.1002/1097-0142(196811)22:6<1156::aid-cncr2820220611>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  7. GOODWIN J. F., KAY J. M., HEATH D. CLINICAL PATHOLOGIC CONFERENCE. Am Heart J. 1965 Aug;70:239–247. doi: 10.1016/0002-8703(65)90073-6. [DOI] [PubMed] [Google Scholar]
  8. Gerbode F., Kerth W. J., Hill J. D. Surgical management of tumors of the heart. Surgery. 1967 Jan;61(1):94–101. [PubMed] [Google Scholar]
  9. Ghahramani A. R., Arnold J. R., Hildner F. J., Sommer L. S., Samet P. Left atrial myxoma: hemodynamic and phonocardiographic features. Am J Med. 1972 Apr;52(4):525–532. doi: 10.1016/0002-9343(72)90043-5. [DOI] [PubMed] [Google Scholar]
  10. Matsuyama K., Oneda G. Histogenesis of primary myxoma of the heart: a case report. Gan. 1967 Oct;58(5):435–440. [PubMed] [Google Scholar]
  11. PRICHARD R. W. Tumors of the heart; review of the subject and report of 150 cases. AMA Arch Pathol. 1951 Jan;51(1):98–128. [PubMed] [Google Scholar]
  12. Read R. C., White H. J., Murphy M. L., Williams D., Sun C. N., Flanagan W. H. The malignant potentiality of left atrial myxoma. J Thorac Cardiovasc Surg. 1974 Dec;68(6):857–868. [PubMed] [Google Scholar]
  13. Schattenberg T. T. Echocardiographic diagnosis of left atrial myxoma. Mayo Clin Proc. 1968 Sep;43(9):620–627. [PubMed] [Google Scholar]
  14. Silverberg S. G., Kay S. Ultrastructure of a cardiac myxoma. Am J Clin Pathol. 1970 Oct;54(4):650–657. doi: 10.1093/ajcp/54.4.650. [DOI] [PubMed] [Google Scholar]
  15. Steiner R. E. Radiologic aspects of cardiac tumors. Am J Cardiol. 1968 Mar;21(3):344–356. doi: 10.1016/0002-9149(68)90138-0. [DOI] [PubMed] [Google Scholar]
  16. Symbas P. N., Abbott O. A., Logan W. D., Hatcher C. R., Jr Atrial myxomas: special emphasis on unusual manifestations. Chest. 1971 May;59(5):504–510. doi: 10.1378/chest.59.5.504. [DOI] [PubMed] [Google Scholar]
  17. Van Den Berg C., Blok A. P. Myxoma cordis: some morphological and enzyme-histochemical aspects. Pathol Eur. 1966;1(1):3–14. [PubMed] [Google Scholar]
  18. WILLMAN V. L., SYMBAS P. N., MAMIYA R. T., COOPER T., HANLON C. R. UNUSUAL ASPECTS OF INTRACAVITARY TUMORS OF THE HEART: REPORT OF TWO CASES. Dis Chest. 1965 Jun;47:669–671. doi: 10.1378/chest.47.6.669. [DOI] [PubMed] [Google Scholar]
  19. Williams W. J., Jenkins D., Erasmus D. The ultrastructure of cardiac myxoma. Thorax. 1970 Nov;25(6):756–761. doi: 10.1136/thx.25.6.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. ZUIDEMA G. D., BURKE J. F., VILLEGAS A. H., SCANNELL J. G. Surgery of atrial myxoma. N Engl J Med. 1961 May 18;264:1016–1021. doi: 10.1056/NEJM196105182642002. [DOI] [PubMed] [Google Scholar]

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