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. 1976 May;183(5):502–510. doi: 10.1097/00000658-197605000-00007

Retrospective analysis of 100 consecutive patients undergoing related living donor renal transplantation.

A G Diethelm, W A Sterling, J S Aldrete, J F Shaw, J M Morgan
PMCID: PMC1344334  PMID: 776105

Abstract

One hundred consecutive patients receiving related donor kidneys were analyzed in regards to graft and patient survival, morbidity, mortality, histocompatibility and rehabilitation. The average followup was 3 years and 2 months with a minimum post transplant evaluation of one year. Donor morbidity was minimal and the mortality nil. Recipient mortality was 17%, all of which occurred after the first two post transplant months. The most serious life threatening complications after transplantation were due to infection. The greatest morbidity was secondary to aseptic necrosis. The overall graft survival at one year was 94%, 2 years--87%, 3 years--81% and 4 and 5 years--72%. Separation of patients according to tissue typing revealed 95% of recipients with A and B matched kidneys to be alive 5 years later compared to 55% of patients receiving C and D matched kidneys. Rehabilitation was good to excellent in 76% of the living patients and poor in only 4%. These results suggest related donor renal transplantation to be the treatment of choice for patients with chronic renal failure excluding only those individuals who are exceptionally high risks in terms of morbidity and mortality.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. J., Schafer L. A., Olin D. B., Eickhoff T. C. Septicemia in renal transplant recipients. Arch Surg. 1973 May;106(5):692–694. doi: 10.1001/archsurg.1973.01350170058014. [DOI] [PubMed] [Google Scholar]
  2. BERKSON J., GAGE R. P. Calculation of survival rates for cancer. Proc Staff Meet Mayo Clin. 1950 May 24;25(11):270–286. [PubMed] [Google Scholar]
  3. Bennett A. H., Harrison J. H. Experience with living familial renal donors. Surg Gynecol Obstet. 1974 Dec;139(6):894–898. [PubMed] [Google Scholar]
  4. Briggs W. A., Hampers C. L., Merrill J. P., Hager E. B., Wilson R. E., Birtch A. G., Murray J. E. Aseptic necrosis in the femur after renal transplantation. Ann Surg. 1972 Feb;175(2):282–289. doi: 10.1097/00000658-197202000-00022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Diethelm A. G., Aldrete J. S., Shaw J. F., Cobbs C. G., Hartley M. W., Sterling W. A., Morgan J. M. Clinical evaluation of equine antithymocyte globulin in recipients of renal allografts: Analysis of survival, renal function, rejection, histocompatibility, and complications. Ann Surg. 1974 Jul;180(1):20–28. doi: 10.1097/00000658-197407000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Diethelm A. G., Aldrete J. S., Sterling W. A., Morgan J. M. Large volume diuresis as a mechanism for immediate maximum renal function after transplantation. Surg Gynecol Obstet. 1974 Jun;138(6):869–874. [PubMed] [Google Scholar]
  7. Gallis H. A., Berman R. A., Cate T. R., Hamilton J. D., Gunnells J. C., Stickel D. L. Fungal infection following renal transplantation. Arch Intern Med. 1975 Sep;135(9):1163–1172. [PubMed] [Google Scholar]
  8. Kountz S. L., Belzer F. O. The fate of patients after renal transplantation, graft rejection, and retransplantation. Ann Surg. 1972 Oct;176(4):509–520. doi: 10.1097/00000658-197210000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lowrie E. G., Lazarus J. M., Mocelin A. J., Bailey G. L., Hampers C. L., Wilson R. E., Merrill J. P. Survival of patients undergoing chronic hemodialysis and renal transplantation. N Engl J Med. 1973 Apr 26;288(17):863–867. doi: 10.1056/NEJM197304262881701. [DOI] [PubMed] [Google Scholar]
  10. Moore T. C., Hume D. M. The period and nature of hazard in clinical renal transplantation. I. The hazard to patient survival. Ann Surg. 1969 Jul;170(1):1–11. doi: 10.1097/00000658-196907000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Penn I., Durst A. L., Machado M., Halgrimson C. G., Booth A. S., Jr, Putman C. W., Groth C. G., Starzl T. E. Acute pancreatitis and hyperamylasemia in renal homograft recipients. Arch Surg. 1972 Aug;105(2):167–172. doi: 10.1001/archsurg.1972.04180080021004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Penn I., Halgrimson C. G., Ogden D., Starzl T. E. Use of living donors in kidney transplantation in man. Arch Surg. 1970 Aug;101(2):226–231. doi: 10.1001/archsurg.1970.01340260130021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ruiz J. O., Simmons R. L., Callender C. O., Kjellstrand C. M., Buselmeier T. J., Najarian J. S. Steroid diabetes in renal transplant recipients: pathogenetic factors and prognosis. Surgery. 1973 May;73(5):759–765. [PubMed] [Google Scholar]
  14. Schweizer R. T., Kountz S. L., Belzer F. O. Wound complications in recipients of renal transplants. Ann Surg. 1973 Jan;177(1):58–62. doi: 10.1097/00000658-197301000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Siegel R. R., Luke R. G., Hellebusch A. A. Reduction of toxicity of corticosteroid therapy after renal transplantation. Am J Med. 1972 Aug;53(2):159–169. doi: 10.1016/0002-9343(72)90126-x. [DOI] [PubMed] [Google Scholar]
  16. Simmons R. L., Kjellstrand C. M., Buselmeier T. J., Najarian J. S. Renal transplantation in high-risk patients. Arch Surg. 1971 Aug;103(2):290–298. doi: 10.1001/archsurg.1971.01350080206032. [DOI] [PubMed] [Google Scholar]
  17. Simmons R. L., Uranga V. M., LaPlante E. S., Buselmeier T. J., Kjellstrand C. M., Najarian J. S. Pulmonary complications in transplant recipients. Arch Surg. 1972 Aug;105(2):260–268. doi: 10.1001/archsurg.1972.04180080112019. [DOI] [PubMed] [Google Scholar]
  18. Spanos P. K., Simmons R. L., Lampe E., Rattazzi L. C., Kjellstrand C. M., Goetz F. C., Najarian J. S. Complications of related kidney donation. Surgery. 1974 Nov;76(5):741–747. [PubMed] [Google Scholar]
  19. Starzl T. E., Groth C. G., Putnam C. W., Penn I., Halgrimson C. G., Flatmark A., Gecelter L., Brettschneider L., Stonington O. G. Urological complications in 216 human recipients of renal transplants. Ann Surg. 1970 Jul;172(1):1–22. [PMC free article] [PubMed] [Google Scholar]
  20. Starzl T. E., Porter K. A., Halgrimson C. G., Husberg B. S., Penn I., Putnam C. W. A decade followup in early cases of renal homotransplantation. Ann Surg. 1974 Oct;180(4):606–616. doi: 10.1097/00000658-197410000-00026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stickel D. L., Seigler H. F., Amos D. B., Ward F. E., Gunnells J. C., Jr, Price A. R., Anderson E. E. Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping. Ann Surg. 1970 Aug;172(2):160–179. doi: 10.1097/00000658-197008000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tilney N. L., Collins J. J., Jr, Wilson R. E. Hemorrhagic pancreatitis. A fatal complication of renal transplantation. N Engl J Med. 1966 May 12;274(19):1051–1057. doi: 10.1056/NEJM196605122741903. [DOI] [PubMed] [Google Scholar]

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