Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1979 Jul;190(1):69–71. doi: 10.1097/00000658-197907000-00015

Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast.

J L Hoehn, E D Plotka, K B Dickson
PMCID: PMC1344460  PMID: 464682

Abstract

The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor.

Full text

PDF
69

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Block G. E., Ellis R. S., DeSombre E., Jensen E. Correlation of estrophilin content of primary mammary cancer to eventual endocrine treatment. Ann Surg. 1978 Sep;188(3):372–376. doi: 10.1097/00000658-197809000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Block G. E., Jensen E. V., Polley T. Z. The prediction of hormonal dependency of mammary cancer. Ann Surg. 1975 Sep;182(3):342–352. doi: 10.1097/00000658-197509000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DeSombre E. R., Smith S., Block G. E., Ferguson D. J., Jensen E. V. Prediction of breast cancer response to endocrine therapy. Cancer Chemother Rep. 1974 Jul-Aug;58(4):513–519. [PubMed] [Google Scholar]
  4. Leclercq G., Heuson J. C., Deboel M. C., Mattheiem W. H. Oestrogen receptors in breast cancer: a changing concept. Br Med J. 1975 Jan 25;1(5951):185–189. doi: 10.1136/bmj.1.5951.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Liskowski L., Rose D. P. Experience with a simple method for estrogen receptor assay in breast cancer. Clin Chim Acta. 1976 Mar 1;67(2):175–182. doi: 10.1016/0009-8981(76)90257-6. [DOI] [PubMed] [Google Scholar]
  6. McGuire W. L. Current status of estrogen receptors in human breast cancer. Cancer. 1975 Aug;36(2):638–644. doi: 10.1002/1097-0142(197508)36:2+<638::aid-cncr2820360805>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  7. Rosen P. P., Menendez-Botet C. J., Urban J. A., Fracchia A., Schwartz M. K. Estrogen receptor protein (ERP) in multiple tumor specimens from individual patients with breast cancer. Cancer. 1977 May;39(5):2194–2200. doi: 10.1002/1097-0142(197705)39:5<2194::aid-cncr2820390537>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  8. Singhakowinta A., Potter H. G., Buroker T. R., Samal B., Brooks S. C., Vaitkevicius V. K. Estrogen receptor and natural course of breast cancer. Ann Surg. 1976 Jan;183(1):84–88. doi: 10.1097/00000658-197601000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Walt A. J., Singhakowinta A., Brooks S. C., Cortez A. The surgical implications of estrophile protein estimations in carcinoma of the breast. Surgery. 1976 Oct;80(4):506–512. [PubMed] [Google Scholar]
  10. Webster D. J., Bronn D. G., Minton J. P. Estrogen receptor levels in multiple biopsies from patients with breast cancer. Am J Surg. 1978 Sep;136(3):337–338. doi: 10.1016/0002-9610(78)90289-1. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES