Abstract
Normal and abnormal parathyroid glands removed surgically from 50 consecutive patients with primary hyperparathyroidism were studied by means of hematoxylin and eosin and oil-red-O stains. This was done to establish the incidence of the different pathological entities in our patient material, and to evaluate the role of the oil-red-O stain in the diagnostic histopathological process. The oil-red-O stain distinctly separates abnormally hyperfunctioning from normal or suppressed parathyroid tissue. Therefore, it is a valuable tool in the pathologic evaluation of patients with hyperparathyroidism. Chief cell adenomas were the most frequent lesions (88%), while diffuse hyperplasia was seen less commonly (10%) and carcinoma infrequently (2%). These findings justify a surgically conservative approach as the most desirable in managing patients with primary hyperparathyroidism.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Castleman B., Schantz A., Roth S. Parathyroid hyperplasia in primary hyperparathyroidism: a review of 85 cases. Cancer. 1976 Oct;38(4):1668–1675. doi: 10.1002/1097-0142(197610)38:4<1668::aid-cncr2820380438>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
- Coffey R. J., Lee T. C., Canary J. J. The surgical treatment of primary hyperparathyroidism: a 20 year experience. Ann Surg. 1977 May;185(5):518–523. doi: 10.1097/00000658-197705000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edis A. J., Beahrs O. H., van Heerden J. A., Akwari O. E. "Conservative" versus "liberal" approach to parathyroid neck exploration. Surgery. 1977 Oct;82(4):466–473. [PubMed] [Google Scholar]
- Ejerblad S., Grimelius L., Johansson H., Werner I. Studies on the non-adenomatous glands in patients with a solitary parathyroid adenoma. Ups J Med Sci. 1976;81(1):31–36. doi: 10.3109/03009737609179019. [DOI] [PubMed] [Google Scholar]
- Esselstyn C. B., Jr, Levin H. S., Eversman J. J., Schumacher O. P., Skillern P. G. Reappraisal of parathyroid pathology in hyperparathyroidism. Surg Clin North Am. 1974 Apr;54(2):443–447. doi: 10.1016/s0039-6109(16)40290-2. [DOI] [PubMed] [Google Scholar]
- Grimelius L., Akerström G., Johansson H., Lundqvist H. Estimation of parenchymal cell content of human parathyroid glands using the image analyzing computer technique. Am J Pathol. 1978 Dec;93(3):793–800. [PMC free article] [PubMed] [Google Scholar]
- Haff R. C., Armstrong R. G. Trends in the current management of primary hyperparathyroidism. Surgery. 1974 May;75(5):715–719. [PubMed] [Google Scholar]
- Johansson H., Thorén L., Werner I. Hyperparathyroidism. Clinical experiences from 208 cases. Ups J Med Sci. 1972;77(1):41–46. doi: 10.1517/03009734000000008. [DOI] [PubMed] [Google Scholar]
- Kay S. The abnormal parathyroid. Hum Pathol. 1976 Mar;7(2):127–138. doi: 10.1016/s0046-8177(76)80015-9. [DOI] [PubMed] [Google Scholar]
- Krementz E. T., Yeager R., Hawley W., Weichert R. The first 100 cases of parathyroid tumor from Charity Hospital of Louisiana. Ann Surg. 1971 Jun;173(6):872–883. doi: 10.1097/00000658-197106010-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Livesay J. J., Mulder D. G. Recurrent hyperparathyroidism. Arch Surg. 1976 Jun;111(6):688–691. doi: 10.1001/archsurg.1976.01360240068012. [DOI] [PubMed] [Google Scholar]
- Roth S. I., Gallagher M. J. The rapid identification of "normal" parathyroid glands by the presence of intracellular fat. Am J Pathol. 1976 Sep;84(3):521–528. [PMC free article] [PubMed] [Google Scholar]
- Roth S. I., Wang C. A., Potts J. T., Jr The team approach to primary hyperparathyroidism. Hum Pathol. 1975 Nov;6(6):645–648. doi: 10.1016/s0046-8177(75)80073-6. [DOI] [PubMed] [Google Scholar]
- Straus F. H., 2nd, Paloyan E. The pathology of hyperparathyroidism. Surg Clin North Am. 1969 Feb;49(1):27–42. doi: 10.1016/s0039-6109(16)38732-1. [DOI] [PubMed] [Google Scholar]