Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1980 Dec;192(6):762–771. doi: 10.1097/00000658-198012000-00012

Angiogenic activity as a marker of neoplastic and preneoplastic lesions of the human bladder.

G W Chodak, C Haudenschild, R F Gittes, J Folkman
PMCID: PMC1344977  PMID: 6160821

Abstract

Angiogenic activity has been assessed in biopsy specimens from 49 patients with transitional cell carcinoma, benign prostatic hypertrophy and vesicoureteral reflux. Over 95% of the specimens containing malignant and premalignant transitional epithelium stimulated capillary proliferation on rabbit iris. In contrast, less than 10% of normal tissues had this effect. Sixty-one per cent of specimens with inflammatory round cells were angiogenic but this was reduced to 10% by preincubation with rabbit antihuman lymphocyte serum. Cystitis cystica also induced capillary proliferation even if incubated with the antilymphocyte serum. Angiogenic capacity may be an early marker of preneoplastic and neoplastic lesions of the human bladder.

Full text

PDF
762

Images in this article

764Fig. 2.
on p.764
764Fig. 3.
on p.764
766Fig. 4.
on p.766
767Fig. 5.
on p.767
769Fig. 7.
on p.769
770Fig. 8.
on p.770

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Auerbach R., Kubai L., Sidky Y. Angiogenesis induction by tumors, embryonic tissues, and lymphocytes. Cancer Res. 1976 Sep;36(9 Pt 2):3435–3440. [PubMed] [Google Scholar]
  2. Brem S. S., Gullino P. M., Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science. 1977 Mar 4;195(4281):880–882. doi: 10.1126/science.402692. [DOI] [PubMed] [Google Scholar]
  3. Brem S. S., Jensen H. M., Gullino P. M. Angiogenesis as a marker of preneoplastic lesions of the human breast. Cancer. 1978 Jan;41(1):239–244. doi: 10.1002/1097-0142(197801)41:1<239::aid-cncr2820410133>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  4. Folkman J., Cotran R. Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol. 1976;16:207–248. [PubMed] [Google Scholar]
  5. Gimbrone M. A., Jr, Gullino P. M. Angiogenic capacity of preneoplastic lesions of the murine mammary gland as a marker of neoplastic transformation. Cancer Res. 1976 Jul;36(7 Pt 2):2611–2620. [PubMed] [Google Scholar]
  6. Gimbrone M. A., Jr, Gullino P. M. Neovascularization induced by intraocular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues. J Natl Cancer Inst. 1976 Feb;56(2):305–318. doi: 10.1093/jnci/56.2.305. [DOI] [PubMed] [Google Scholar]
  7. Gimbrone M. A., Jr, Leapman S. B., Cotran R. S., Folkman J. Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst. 1973 Jan;50(1):219–228. doi: 10.1093/jnci/50.1.219. [DOI] [PubMed] [Google Scholar]
  8. Heney N. M., Daly J., Prout G. R., Jr, Nieh P. T., Heaney J. A., Trebeck N. E. Biopsy of apparently normal urothelium in patients with bladder carcinoma. J Urol. 1978 Nov;120(5):559–560. doi: 10.1016/s0022-5347(17)57275-4. [DOI] [PubMed] [Google Scholar]
  9. Hicks R. M., Chowaniec J. Experimental induction, histology, and ultrastructure of hyperplasia and neoplasia of the urinary bladder epithelium. Int Rev Exp Pathol. 1978;18:199–280. [PubMed] [Google Scholar]
  10. Levey R. H., Medawar P. B. Nature and mode of action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130–1137. doi: 10.1073/pnas.56.4.1130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Maiorana A., Gullino P. M. Acquisition of angiogenic capacity and neoplastic transformation in the rat mammary gland. Cancer Res. 1978 Dec;38(12):4409–4414. [PubMed] [Google Scholar]
  12. Marshall C. J., Franks L. M., Carbonell A. W. Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas. J Natl Cancer Inst. 1977 Jun;58(6):1743–1751. doi: 10.1093/jnci/58.6.1743. [DOI] [PubMed] [Google Scholar]
  13. Polverini P. J., Cotran P. S., Gimbrone M. A., Jr, Unanue E. R. Activated macrophages induce vascular proliferation. Nature. 1977 Oct 27;269(5631):804–806. doi: 10.1038/269804a0. [DOI] [PubMed] [Google Scholar]
  14. Schade R. O., Swinney J. The association of urothelial atypism with neoplasia: its importance in treatment and prognosis. J Urol. 1973 Apr;109(4):619–622. doi: 10.1016/s0022-5347(17)60496-8. [DOI] [PubMed] [Google Scholar]
  15. Skinner D. G., Richie J. P., Cooper P. H., Waisman J., Kaufman J. J. The clinical significance of carcinoma in situ of the bladder and its association with overt carcinoma. J Urol. 1974 Jul;112(1):68–71. doi: 10.1016/s0022-5347(17)59645-7. [DOI] [PubMed] [Google Scholar]
  16. Skinner D. G., Richie J. P., Cooper P. H., Waisman J., Kaufman J. J. The clinical significance of carcinoma in situ of the bladder and its association with overt carcinoma. J Urol. 1974 Jul;112(1):68–71. doi: 10.1016/s0022-5347(17)59645-7. [DOI] [PubMed] [Google Scholar]
  17. Tatematsu M., Cohen S. M., Fukushima S., Shirai T., Shinohara Y., Ito N. Neovascularization in benign and malignant urinary bladder epithelial proliferative lesions of the rat observed in situ by scanning electron microscopy and autoradiography. Cancer Res. 1978 Jun;38(6):1792–1800. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES