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. 1981 Jan;193(1):82–88. doi: 10.1097/00000658-198101000-00014

Transient hepatic dearterialization followed by regional intra-arterial 5-fluorouracil infusion as treatment for liver tumors.

E P Dahl, P E Frelund, U Tylén, S Bengmark
PMCID: PMC1345007  PMID: 7458454

Abstract

Twenty consecutive patients with secondary liver tumors were treated with a new method of liver dearterialization, performed by transient occlusion of the hepatic artery with strangulating slings, and followed by regional intra-arterial infusion of 5-fluorouracil. Tumor regression was confirmed by angiography, laboratory tests and symptom relief in more than 50% of the patients. For patients with metastatic colorectal carcinoma the mean survival time after operation was 17 months and the median survival time was 11 months. The most common complications were abscesses and aneurysms. The treatment is judged suitable for patients with a tumor of moderate severity involving both liver lobes and without extrahepatic tumor growth.

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Selected References

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  1. Ackerman N. B., Lien W. M., Kondi E. S., Silverman N. A. The blood supply of experimental liver metastases. I. The distribution of hepatic artery and portal vein blood to "small" and "large" tumors. Surgery. 1969 Dec;66(6):1067–1072. [PubMed] [Google Scholar]
  2. Almersjö O., Bengmark S., Hafström L., Leissner K. H. Results of liver dearterialization combined with regional infusion of 5-fluorouracil for liver cancer. Acta Chir Scand. 1976;142(2):131–138. [PubMed] [Google Scholar]
  3. Almersjö O., Bengmark S., Rudenstam C. M., Hafström L., Nilsson L. A. Evaluation of hepatic dearterialization in primary and secondary cancer of the liver. Am J Surg. 1972 Jul;124(1):5–9. doi: 10.1016/0002-9610(72)90155-9. [DOI] [PubMed] [Google Scholar]
  4. Ansfield F. J., Ramirez G., Davis H. L., Jr, Wirtanen G. W., Johnson R. O., Bryan G. T., Manalo F. B., Borden E. C., Davis T. E., Esmili M. Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil. Cancer. 1975 Dec;36(6 Suppl):2413–2417. doi: 10.1002/1097-0142(197512)36:6<2413::aid-cncr2820360621>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  5. BREEDIS C., YOUNG G. The blood supply of neoplasms in the liver. Am J Pathol. 1954 Sep-Oct;30(5):969–977. [PMC free article] [PubMed] [Google Scholar]
  6. Balasegaram M. Complete hepatic dearterialization for primary carcinoma of the liver. Report of twenty-four patients. Am J Surg. 1972 Sep;124(3):340–345. doi: 10.1016/0002-9610(72)90038-4. [DOI] [PubMed] [Google Scholar]
  7. Bengmark S., Fredlund P., Hafström L. O., Vang J. Present experiences with hepatic dearterialization in liver neoplasm. Prog Surg. 1974;13:141–166. doi: 10.1159/000395682. [DOI] [PubMed] [Google Scholar]
  8. Bengmark S., Hafström L. The natural history of primary and secondary malignant tumors of the liver. I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. Cancer. 1969 Jan;23(1):198–202. doi: 10.1002/1097-0142(196901)23:1<198::aid-cncr2820230126>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  9. Bengmark S., Rosengren K. Angiographic study of the collateral circulation to the liver after ligation of the hepatic artery in man. Am J Surg. 1970 Jun;119(6):620–624. doi: 10.1016/0002-9610(70)90228-x. [DOI] [PubMed] [Google Scholar]
  10. Cady B. Hepatic arterial patency and complications after catheterization for infusion chemotherapy. Ann Surg. 1973 Aug;178(2):156–161. doi: 10.1097/00000658-197308000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. DANNEBERG P. B., MONTAG B. J., HEIDELBERGER C. Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo. Cancer Res. 1958 Apr;18(3):329–334. [PubMed] [Google Scholar]
  12. Gulesserian H. P., Lawton R. L., Condon R. E. Hepatic artery ligation and cytotoxic infusion in treatment of liver metastases. Arch Surg. 1972 Aug;105(2):280–285. doi: 10.1001/archsurg.1972.04180080132022. [DOI] [PubMed] [Google Scholar]
  13. HEALEY J. E., Jr VASCULAR PATTERNS IN HUMAN METASTATIC LIVER TUMORS. Surg Gynecol Obstet. 1965 Jun;120:1187–1193. [PubMed] [Google Scholar]
  14. Jaffe B. M., Donegan W. L., Watson F., Spratt J. S., Jr Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet. 1968 Jul;127(1):1–11. [PubMed] [Google Scholar]
  15. Jochimsen P. R., Zike W. L., Shirazi S. S., Pearlman N. W. Iatrogenic liver abscesses. A complication of hepatic artery ligation for tumor. Arch Surg. 1978 Feb;113(2):141–144. doi: 10.1001/archsurg.1978.01370140031006. [DOI] [PubMed] [Google Scholar]
  16. MICHELS N. A. Collateral arterial pathways to the liver after ligation of the hepatic artery and removal of the celiac axis. Cancer. 1953 Jul;6(4):708–724. doi: 10.1002/1097-0142(195307)6:4<708::aid-cncr2820060411>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  17. Mays E. T., Wheeler C. S. Demonstration of collateral arterial flow after interruption of hepatic arteries in man. N Engl J Med. 1974 May 2;290(18):993–996. doi: 10.1056/NEJM197405022901804. [DOI] [PubMed] [Google Scholar]
  18. Mokka R. E., Larmi T. K., Huttunen R., Kairaluoma M. I. Evaluation of the ligation of the hepatic artery and regional arterial chemotherapy in the treatment of primary and secondary cancer of the liver. Ann Chir Gynaecol Fenn. 1975;64(6):347–352. [PubMed] [Google Scholar]
  19. Mori W., Masuda M., Miyanaga T. Hepatic artery ligation and tumor necrosis in the liver. Surgery. 1966 Mar;59(3):359–363. [PubMed] [Google Scholar]
  20. Murray-Lyon I. M., Parsons V. A., Blendis L. M., Dawson J. L., Rake M. O., Laws J. W., Williams R. Treatment of secondary hepatic tumours by ligation of hepatic artery and infusion of cytotoxic drugs. Lancet. 1970 Jul 25;2(7665):172–175. doi: 10.1016/s0140-6736(70)92533-x. [DOI] [PubMed] [Google Scholar]
  21. Nilsson L. A. Therapeutic hepatic artery ligation in patients with secondary liver tumors. Rev Surg. 1966 Sep-Oct;23(5):374–376. [PubMed] [Google Scholar]
  22. Nilsson L. A., Zettergren L. Effect of hepatic artery ligation on induced primary liver carcinoma in rats. Preliminary report. Acta Pathol Microbiol Scand. 1967;71(2):187–193. doi: 10.1111/j.1699-0463.1967.tb05157.x. [DOI] [PubMed] [Google Scholar]
  23. Plengvanit U., Chearanai O., Sindhvananda K., Dambrongsak D., Tuchinda S., Viranuvatti V. Collateral arterial blood supply of the liver after hepatic artery ligation, angiographic study of twenty patients. Ann Surg. 1972 Jan;175(1):105–110. doi: 10.1097/00000658-197201000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ramming K. P., Sparks F. C., Eilber F. R., Holmes E. C., Morton D. L. Hepatic artery ligation and 5-fluorouracil infusion for metastatic colon carcinoma and primary hepatoma. Am J Surg. 1976 Aug;132(2):236–242. doi: 10.1016/0002-9610(76)90054-4. [DOI] [PubMed] [Google Scholar]
  25. Sundqvist K., Hafström L. O., Jönsson P. E., Rydén S., Forsberg L., Lunderquist A. Treatment of liver cancer with regional intraarterial 5-FU infusion. Am J Surg. 1978 Sep;136(3):328–331. doi: 10.1016/0002-9610(78)90286-6. [DOI] [PubMed] [Google Scholar]
  26. Vandamme J. P., Bonte J., Van der Schueren G. A revaluation of hepatic and cystic arteries. The importance of the aberrant hepatic branches. Acta Anat (Basel) 1969;73(2):192–209. doi: 10.1159/000143296. [DOI] [PubMed] [Google Scholar]
  27. Watkins E., Jr, Khazei A. M., Nahra K. S. Surgical basis for arterial infusion chemotherapy of disseminated carcinoma of the liver. Surg Gynecol Obstet. 1970 Apr;130(4):581–605. [PubMed] [Google Scholar]
  28. Wirtanen G. W. Percutaneous transbrachial artery infusion catheter techniques. Am J Roentgenol Radium Ther Nucl Med. 1973 Mar;117(3):696–700. doi: 10.2214/ajr.117.3.696. [DOI] [PubMed] [Google Scholar]
  29. Zike W. L., Safaie-Shirazi S., Gulesserian H. P. Hepatic artery ligation and cytotoxic infusion in treatment of liver neoplasms. Arch Surg. 1975 May;110(5):641–643. doi: 10.1001/archsurg.1975.01360110187031. [DOI] [PubMed] [Google Scholar]

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