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. 1981 May;193(5):598–605. doi: 10.1097/00000658-198105000-00009

A new concept in the management of Marjolin's ulcers.

R F Ryan, M S Litwin, E T Krementz
PMCID: PMC1345126  PMID: 7235765

Abstract

Marjolin's ulcers have a grave prognosis, especially when regional nodes are involved. Recent studies suggest such cancers are in an immunologically privileges sites due to the dense scar tissue. The prognosis has been shown to be much worse for tumors not having a round cell infiltrate prior to surgery, as in Marjolin's ulcers. The use of topical 5-fluorouracil (5-FU) induces a round cell infiltrate. Three case reports of large Marjolin's ulcers are presented which were first treated with topical 5-FU. Radical ablative surgery was avoided in these patients with a successful outcome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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