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. 1979 Dec;190(6):728–731. doi: 10.1097/00000658-197912000-00009

Experimental acute pancreatitis: the changes in pancreatic oxygen consumption and the effect of Dextran 40.

L A Donaldson, W G Schenk Jr
PMCID: PMC1345630  PMID: 518173

Abstract

A canine model was devised to measure the oxygen consumption of the pancreas in experimentally induced pancreatitis. Over the 120 minute investigation period the oxygen consumption fell by 63% in the presence of a diminishing pancreatic blood flow and constant arteriovenous percentage saturation across the pancreas. Dextran 40 has been previously shown to maintain the pancreatic circulation. Accordingly a second group of dogs was treated with Dextran 40 (1.5 ml/kg) 60 minutes after induction of the pancreatitis. This produced a significant increase in the pancreatic oxygen consumption and widening of the arteriovenous difference. Dextran 40 appears to reverse the hypoxia of the pancreas noted in acute experimental pancreatitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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