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. 1985 Apr 1;132(7):798–800.

Prevention of alcohol withdrawal seizures with oral diazepam loading

Paul Devenyi, Marion L Harrison
PMCID: PMC1345869  PMID: 3978501

Abstract

Twenty patients withdrawing from alcohol who had reliable histories of previous alcohol-withdrawal seizures and thus were at high risk for a subsequent seizure were treated in hospital with oral diazepam loading: 20 mg of the drug was given every hour to a minimum total of 60 mg. None of the patients had a seizure during the stay in hospital. We believe that phenytoin prophylaxis is not necessary in these circumstances. However, if the patient is already taking phenytoin, this drug should not be abruptly discontinued in the withdrawal period in favour of diazepam loading.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams H. P. Diphenylhydantoin in the treatment of alcohol withdrawal. JAMA. 1971 Oct 25;218(4):598–598. [PubMed] [Google Scholar]
  2. Delgado-Escueta A. V., Treiman D. M., Walsh G. O. The treatable epilepsies. (Second of Two Parts). N Engl J Med. 1983 Jun 30;308(26):1576-8, 1579-84. doi: 10.1056/NEJM198306303082607. [DOI] [PubMed] [Google Scholar]
  3. Gessner P. K. Is diphenylhydantoin effective in treatment of alcohol withdrawal? JAMA. 1972 Feb 21;219(8):1072–1072. [PubMed] [Google Scholar]
  4. Hillbom M. E. Occurrence of cerebral seizures provoked by alcohol abuse. Epilepsia. 1980 Oct;21(5):459–466. doi: 10.1111/j.1528-1157.1980.tb04296.x. [DOI] [PubMed] [Google Scholar]
  5. Koch-Weser J., Sellers E. M., Kalant H. Alcohol intoxication and withdrawal. N Engl J Med. 1976 Apr 1;294(14):757–762. doi: 10.1056/NEJM197604012941405. [DOI] [PubMed] [Google Scholar]
  6. Rothstein E. Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide. Am J Psychiatry. 1973 Dec;130(12):1381–1382. doi: 10.1176/ajp.130.12.1381. [DOI] [PubMed] [Google Scholar]
  7. Sampliner R., Iber F. L. Diphenylhydantoin control of alcohol withdrawal seizures. Results of a controlled study. JAMA. 1974 Dec 4;230(10):1430–1432. [PubMed] [Google Scholar]
  8. Sellers E. M., Naranjo C. A., Harrison M., Devenyi P., Roach C., Sykora K. Diazepam loading: simplified treatment of alcohol withdrawal. Clin Pharmacol Ther. 1983 Dec;34(6):822–826. doi: 10.1038/clpt.1983.256. [DOI] [PubMed] [Google Scholar]
  9. Shaw J. M., Kolesar G. S., Sellers E. M., Kaplan H. L., Sandor P. Development of optimal treatment tactics for alcohol withdrawal. I. Assessment and effectiveness of supportive care. J Clin Psychopharmacol. 1981 Nov;1(6):382–389. doi: 10.1097/00004714-198111000-00006. [DOI] [PubMed] [Google Scholar]
  10. Victor M., Brausch C. The role of abstinence in the genesis of alcoholic epilepsy. Epilepsia. 1967 Mar;8(1):1–20. doi: 10.1111/j.1528-1157.1967.tb03815.x. [DOI] [PubMed] [Google Scholar]
  11. Victor M., Laureno R. Neurologic complications of alcohol abuse: epidemiologic aspects. Adv Neurol. 1978;19:603–617. [PubMed] [Google Scholar]
  12. Wilbur R., Kulik F. A. Anticonvulsant drugs in alcohol withdrawal: use of phenytoin, primidone, carbamazepine, valproic acid, and the sedative anticonvulsants. Am J Hosp Pharm. 1981 Aug;38(8):1138–1143. [PubMed] [Google Scholar]

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