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. 1985 Sep 15;133(6):573–576.

Isolation and geographic distribution of Mycobacterium other than M. tuberculosis in British Columbia, 1972-81

Judith L Isaac-Renton, Edward A Allen, Chuan-Wei Chao, Stefan Grzybowski, Elizabeth I Whittaker, William A Black
PMCID: PMC1346222  PMID: 3928125

Abstract

It has been suggested that the incidence of infection with mycobacteria other than typical tubercle (MOTT) bacilli is increasing. Laboratory and epidemiologic information relating to MOTT infection in British Columbia between 1972 and 1981 was analysed. Patient records for 1960-81 were also analysed. Of the 313 661 laboratory specimens 13 474 yielded Mycobacterium tuberculosis isolates and 3172, MOTT isolates. Over the 10 years the number of M. tuberculosis isolates declined, whereas the absolute and relative numbers of MOTT isolates increased. Members of the highly drug-resistant MAIS complex (M. avium-intracellulare, M. scrofulaceum and M. simiae) accounted for 73.3% of the 1778 potentially pathogenic MOTT isolates. MAIS isolation rates varied geographically. Analysis of patient records revealed 217 MOTT infections, of which 152 (70%) were due to MAIS organisms. Further studies are needed to determine the source of MAIS organisms in order that the infection and the disease may be more clearly understood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn C. H., Lowell J. R., Onstad G. D., Shuford E. H., Hurst G. A. A demographic study of disease due to Mycobacterium kansasii or M intracellulare-avium in Texas. Chest. 1979 Feb;75(2):120–125. doi: 10.1378/chest.75.2.120. [DOI] [PubMed] [Google Scholar]
  2. Ahn C. H., McLarty J. W., Ahn S. S., Ahn S. I., Hurst G. A. Diagnostic criteria for pulmonary disease caused by Mycobacterium kansasii and Mycobacterium intracellulare. Am Rev Respir Dis. 1982 Apr;125(4):388–391. doi: 10.1164/arrd.1982.125.4.388. [DOI] [PubMed] [Google Scholar]
  3. Bone M., Stableforth D. Miliary infection due to Mycobacterium avium-intracellulare. Tubercle. 1981 Sep;62(3):211–213. doi: 10.1016/0041-3879(81)90009-x. [DOI] [PubMed] [Google Scholar]
  4. Cohen R. J., Samoszuk M. K., Busch D., Lagios M. Occult infections with M. intracellulare in bone-marrow biopsy specimens from patients with AIDS. N Engl J Med. 1983 Jun 16;308(24):1475–1476. doi: 10.1056/NEJM198306163082411. [DOI] [PubMed] [Google Scholar]
  5. Edwards F. G. Disease caused by 'atypical' (opportunist) mycobacteria: a whole population review. Tubercle. 1970 Sep;51(3):285–295. doi: 10.1016/0041-3879(70)90021-8. [DOI] [PubMed] [Google Scholar]
  6. Fainstein V., Bolivar R., Mavligit G., Rios A., Luna M. Disseminated infection due to Mycobacterium avium-intracellulare in a homosexual man with Kaposi's sarcoma. J Infect Dis. 1982 Apr;145(4):586–586. doi: 10.1093/infdis/145.4.586. [DOI] [PubMed] [Google Scholar]
  7. Falkinham J. O., 3rd, Parker B. C., Gruft H. Epidemiology of infection by nontuberculous mycobacteria. I. Geographic distribution in the eastern United States. Am Rev Respir Dis. 1980 Jun;121(6):931–937. doi: 10.1164/arrd.1980.121.6.931. [DOI] [PubMed] [Google Scholar]
  8. Good R. C., Snider D. E., Jr Isolation of nontuberculous mycobacteria in the United States, 1980. J Infect Dis. 1982 Dec;146(6):829–833. doi: 10.1093/infdis/146.6.829. [DOI] [PubMed] [Google Scholar]
  9. Gottlieb M. S., Groopman J. E., Weinstein W. M., Fahey J. L., Detels R. The acquired immunodeficiency syndrome. Ann Intern Med. 1983 Aug;99(2):208–220. doi: 10.7326/0003-4819-99-2-208. [DOI] [PubMed] [Google Scholar]
  10. Greene J. B., Sidhu G. S., Lewin S., Levine J. F., Masur H., Simberkoff M. S., Nicholas P., Good R. C., Zolla-Pazner S. B., Pollock A. A. Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers. Ann Intern Med. 1982 Oct;97(4):539–546. doi: 10.7326/0003-4819-97-4-539. [DOI] [PubMed] [Google Scholar]
  11. Lakshminarayan S., Sahn S. Disseminated infection caused by Mycobacterium avium. Report of a case with associated leukopenia. Am Rev Respir Dis. 1973 Jul;108(1):123–126. doi: 10.1164/arrd.1973.108.1.123. [DOI] [PubMed] [Google Scholar]
  12. Marks J. "Opportunist" mycobacteria in England and Wales. Tubercle. 1969 Mar;50(Suppl):78–80. [PubMed] [Google Scholar]
  13. McSwiggan D. A., Collins C. H. The isolation of M. kansasii and M. xenopi from water systems. Tubercle. 1974 Dec;55(4):291–297. doi: 10.1016/0041-3879(74)90038-5. [DOI] [PubMed] [Google Scholar]
  14. TIMPE A., RUNYON E. H. The relationship of atypical acid-fast bacteria to human disease; a preliminary report. J Lab Clin Med. 1954 Aug;44(2):202–209. [PubMed] [Google Scholar]
  15. Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis. 1979 Jan;119(1):107–159. doi: 10.1164/arrd.1979.119.1.107. [DOI] [PubMed] [Google Scholar]
  16. Wolinsky E., Rynearson T. K. Mycobacteria in soil and their relation to disease-associated strains. Am Rev Respir Dis. 1968 Jun;97(6):1032–1037. doi: 10.1164/arrd.1968.97.6P1.1032. [DOI] [PubMed] [Google Scholar]
  17. YOUMANS G. P. THE PATHOGENIC "ATYPICAL" MYCOBACTERIA. Annu Rev Microbiol. 1963;17:473–494. doi: 10.1146/annurev.mi.17.100163.002353. [DOI] [PubMed] [Google Scholar]
  18. Zakowski P., Fligiel S., Berlin G. W., Johnson L., Jr Disseminated Mycobacterium avium-intracellulare infection in homosexual men dying of acquired immunodeficiency. JAMA. 1982 Dec 10;248(22):2980–2982. doi: 10.1001/jama.1982.03330220024029. [DOI] [PubMed] [Google Scholar]

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