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. 1978;12:205–213.

New knowledge of the pathogenesis of gout

J T Scott 1,2
PMCID: PMC1347140  PMID: 32192

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson R. M., Chan Y. K. New Haven survey of joint diseases. The prediction of serum uric acid in a general population. J Chronic Dis. 1969 Jan;21(8):543–553. doi: 10.1016/0021-9681(69)90050-2. [DOI] [PubMed] [Google Scholar]
  2. Agudelo C. A., Schumacher H. R., Phelps P. Effect of exercise on urate crystal-induced inflammation in canine joints. Arthritis Rheum. 1972 Nov-Dec;15(6):609–616. doi: 10.1002/art.1780150607. [DOI] [PubMed] [Google Scholar]
  3. Campion D. S., Olsen R., Bluestone R., Klinenberg J. R. Binding of urate by serum proteins. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):747–749. doi: 10.1002/art.1780180718. [DOI] [PubMed] [Google Scholar]
  4. Chang Y. H., Garalla E. J. Suppression of urate crystal-induced canine joint inflammation by heterologous anti-polymorphonuclear leukocyte serum. Arthritis Rheum. 1968 Apr;11(2):145–150. doi: 10.1002/art.1780110204. [DOI] [PubMed] [Google Scholar]
  5. Fessel W. J. Hyperuricemia in health and disease. Semin Arthritis Rheum. 1972 Spring;1(4):275–299. doi: 10.1016/0049-0172(78)90006-9. [DOI] [PubMed] [Google Scholar]
  6. Ginsberg M. H., Kozin F., O'Malley M., McCarty D. J. Release of platelet constituents by monosodium urate crystals. J Clin Invest. 1977 Nov;60(5):999–1007. doi: 10.1172/JCI108880. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hall A. P., Barry P. E., Dawber T. R., McNamara P. M. Epidemiology of gout and hyperuricemia. A long-term population study. Am J Med. 1967 Jan;42(1):27–37. doi: 10.1016/0002-9343(67)90004-6. [DOI] [PubMed] [Google Scholar]
  8. Katz W. A. Deposition of urate crystals in gout. Altered connective tissue metabolism. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):751–756. doi: 10.1002/art.1780180719. [DOI] [PubMed] [Google Scholar]
  9. Kellermeyer R. W., Naff G. B. Chemical mediators of inflammation in acute gouty arthritis. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):765–770. doi: 10.1002/art.1780180721. [DOI] [PubMed] [Google Scholar]
  10. Kippen I., Klinenberg J. R., Weinberger A., Wilcox W. R. Factors affecting urate solubility in vitro. Ann Rheum Dis. 1974 Jul;33(4):313–317. doi: 10.1136/ard.33.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kjellstrand C. M., Cambell D. C., 2nd, von Hartitzsch B., Buselmeier T. J. Hyperuricemic acute renal failure. Arch Intern Med. 1974 Mar;133(3):349–359. [PubMed] [Google Scholar]
  12. Loeb J. N. The influence of temperature on the solubility of monosodium urate. Arthritis Rheum. 1972 Mar-Apr;15(2):189–192. doi: 10.1002/art.1780150209. [DOI] [PubMed] [Google Scholar]
  13. MCCARTY D. J., HOLLANDER J. L. Identification of urate crystals in gouty synovial fluid. Ann Intern Med. 1961 Mar;54:452–460. doi: 10.7326/0003-4819-54-3-452. [DOI] [PubMed] [Google Scholar]
  14. Naff G. B., Byers P. H. Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals. J Lab Clin Med. 1973 May;81(5):747–760. [PubMed] [Google Scholar]
  15. Ortel R. W., Newcombe D. S. Acute gouty arthritis and response to colchicine in the virtual absence of synovial-fluid leukocytes. N Engl J Med. 1974 Jun 13;290(24):1363–1364. doi: 10.1056/NEJM197406132902406. [DOI] [PubMed] [Google Scholar]
  16. PEKIN T. J., Jr, ZVAIFLER N. J. HEMOLYTIC COMPLEMENT IN SYNOVIAL FLUID. J Clin Invest. 1964 Jul;43:1372–1382. doi: 10.1172/JCI105013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Phelps P., McCarty D. J., Jr Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes. J Exp Med. 1966 Jul 1;124(1):115–126. doi: 10.1084/jem.124.1.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Phelps P. Polymorphonuclear leukocyte motility in vitro. IV. Colchicine inhibition of chemotactic activity formation after phagocytosis of urate crystals. Arthritis Rheum. 1970 Jan-Feb;13(1):1–9. doi: 10.1002/art.1780130101. [DOI] [PubMed] [Google Scholar]
  19. Rosenthale M. E., Dervinis A., Kassarich J., Singer S. Prostaglandins and anti-inflammatory drugs in the dog knee joint. J Pharm Pharmacol. 1972 Feb;24(2):149–150. doi: 10.1111/j.2042-7158.1972.tb08948.x. [DOI] [PubMed] [Google Scholar]
  20. SOKOLOFF L. The pathology of gout. Metabolism. 1957 May;6(3):230–243. [PubMed] [Google Scholar]
  21. STECHER R. M., HERSH A. H., SOLOMON W. M. The heredity of gout and its relationship to familial hyperuricemia. Ann Intern Med. 1949 Oct;31(4):595–614. doi: 10.7326/0003-4819-31-4-595. [DOI] [PubMed] [Google Scholar]
  22. Schumacher H. R., Phelps P., Agudelo C. A. Urate crystal induced inflammation in dog joints: sequence of synovial changes. J Rheumatol. 1974 Mar;1(1):102–113. [PubMed] [Google Scholar]
  23. Schumacher H. R., Phelps P. Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopic study. Arthritis Rheum. 1971 Jul-Aug;14(4):513–526. doi: 10.1002/art.1780140411. [DOI] [PubMed] [Google Scholar]
  24. Simkin P. A. Local concentration of urate in the pathogenesis of gout. Lancet. 1973 Dec 8;2(7841):1295–1298. doi: 10.1016/s0140-6736(73)92872-9. [DOI] [PubMed] [Google Scholar]
  25. Snaith M. L., Scott J. T. Uric acid clearance in patients with gout and normal subjects. Ann Rheum Dis. 1971 May;30(3):285–289. doi: 10.1136/ard.30.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Spilberg I., Osterland C. K. Anti-inflammatory effect of the trypsin-kallikrein inhibitor in acute arthritis induced by urate crystals in rabbits. J Lab Clin Med. 1970 Sep;76(3):472–479. [PubMed] [Google Scholar]
  27. Spilberg I. Urate crystal arthritis in animals lacking Hageman factor. Arthritis Rheum. 1974 Mar-Apr;17(2):143–148. doi: 10.1002/art.1780170206. [DOI] [PubMed] [Google Scholar]
  28. Sturge R. A., Scott J. T., Hamilton E. B., Liyanage S. P., Dixon A. S., Davies J., Engler C. Multicentre trial of naproxen and phenylbutazone in acute gout. Ann Rheum Dis. 1977 Feb;36(1):80–82. doi: 10.1136/ard.36.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sturge R. A., Scott J. T., Kennedy A. C., Hart D. P., Buchanan W. W. Serum uric acid in England and Scotland. Ann Rheum Dis. 1977 Oct;36(5):420–427. doi: 10.1136/ard.36.5.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. TALBOTT J. H. Gout and blood dyscrasias. Medicine (Baltimore) 1959 May;38(2):173–205. doi: 10.1097/00005792-195905000-00004. [DOI] [PubMed] [Google Scholar]
  31. Townes A. S., Sowa J. M. Complement in synovial fluid. Johns Hopkins Med J. 1970 Jul;127(1):23–37. [PubMed] [Google Scholar]
  32. Van Arman C. G., Carlson R. P., Kling P. J., Allen D. J., Bondi J. V. Experimental gouty synovitis caused by bacterial endotoxin adsorbed onto urate crystals. Arthritis Rheum. 1974 Jul-Aug;17(4):439–449. doi: 10.1002/art.1780170415. [DOI] [PubMed] [Google Scholar]
  33. Wallingford W. R., McCarty D. J. Differential membranolytic effects of microcrystalline sodium urate and calcium pyrophosphate dihydrate. J Exp Med. 1971 Jan 1;133(1):100–112. doi: 10.1084/jem.133.1.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Weissmann G., Rita G. A. Molecular basis of gouty inflammation: interaction of monosodium urate crystals with lysosomes and liposomes. Nat New Biol. 1972 Dec 6;240(101):167–172. doi: 10.1038/newbio240167a0. [DOI] [PubMed] [Google Scholar]
  35. YU T. F., GUTMAN A. B. Ultrafiltrability of plasma urate in man. Proc Soc Exp Biol Med. 1953 Oct;84(1):21–24. doi: 10.3181/00379727-84-20528. [DOI] [PubMed] [Google Scholar]

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