Abstract
Efferent discharges were recorded from nerve filaments dissected from the adrenal and renal nerves in the rabbit. 2. An increase in discharge rate was observed in the adrenal nerve filaments following I.V. administration of 2-deoxy-D-glucose (2-DG). No change in discharge rate after 2-DG infusion was observed in the renal nerve filaments. 3. A decrease in discharge rate of the adrenal nerve filaments was observed after I.V. injection of glucose, but there was no change in the activity of renal nerve filaments. 4. Transection of the spinal cord abolished the adrenal nerve response to the systemic administration of 2-DG and glucose. 5. It is suggested that there might be a pathway from the hypothalmic area to the adrenal nerve cells of the spinal cord, but not to the renal nerve cells, through which activity of the adrenal nerve might be changed in response to 2-DG and glucose infusion.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BROWN J. Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. Metabolism. 1962 Oct;11:1098–1112. [PubMed] [Google Scholar]
- Balagura S., Kanner M. Hypothalamic sensitivity to 2-deoxy-D-glucose and glucose: effects on feeding behavior. Physiol Behav. 1971 Aug;7(2):251–255. doi: 10.1016/0031-9384(71)90292-7. [DOI] [PubMed] [Google Scholar]
- Brown K. A., Melzack R. Effects of glucose on multi-unit activity in the hypothalamus. Exp Neurol. 1969 Jul;24(3):363–373. doi: 10.1016/0014-4886(69)90142-3. [DOI] [PubMed] [Google Scholar]
- Frohman L. A., Bernardis L. L. Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels. Am J Physiol. 1971 Dec;221(6):1596–1603. doi: 10.1152/ajplegacy.1971.221.6.1596. [DOI] [PubMed] [Google Scholar]
- HOKFELT B., BYDGEMAN S. Increased adrenaline production following administration of 2-deoxy-D-glucose in the rat. Proc Soc Exp Biol Med. 1961 Mar;106:537–539. doi: 10.3181/00379727-106-26394. [DOI] [PubMed] [Google Scholar]
- Himsworth R. L. Compensatory reactions to a lack of metabolizable glucose. J Physiol. 1968 Sep;198(2):451–465. doi: 10.1113/jphysiol.1968.sp008616. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Himsworth R. L. Hypothalamic control of adrenaline secretion in response to insufficient glucose. J Physiol. 1970 Feb;206(2):411–417. doi: 10.1113/jphysiol.1970.sp009021. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Müller E. E., Cocchi D., Forni A. A central site for the hyperglycemic action of 2-deoxy-d-glucose in mouse and rat. Life Sci I. 1971 Sep 15;10(18):1057–1067. doi: 10.1016/0024-3205(71)90180-9. [DOI] [PubMed] [Google Scholar]
- OOMURA Y., KIMURA K., OOYAMA H., MAENO T., IKI M., KUNIYOSHI M. RECIPROCAL ACTIVITIES OF THE VENTROMEDIAL AND LATERAL HYPOTHALAMIC AREAS OF CATS. Science. 1964 Jan 31;143(3605):484–485. doi: 10.1126/science.143.3605.484. [DOI] [PubMed] [Google Scholar]
- Oomura Y. Central mechanism of feeding. Adv Biophys. 1973;5(0):65–142. [PubMed] [Google Scholar]
- SAKATA K., HAYANO S., SLOVITER H. A. Effect on blood glucose concentration of changes in availability of glucose to the brain. Am J Physiol. 1963 Jun;204:1127–1132. doi: 10.1152/ajplegacy.1963.204.6.1127. [DOI] [PubMed] [Google Scholar]
- Smith G. P., Epstein A. N. Increased feeding in response to decreased glucose utilization in the rat and monkey. Am J Physiol. 1969 Oct;217(4):1083–1087. doi: 10.1152/ajplegacy.1969.217.4.1083. [DOI] [PubMed] [Google Scholar]
- WOODWARD G. E., HUDSON M. T. The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues. Cancer Res. 1954 Sep;14(8):599–605. [PubMed] [Google Scholar]