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. 1975 Oct;251(2):271–279. doi: 10.1113/jphysiol.1975.sp011091

Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs.

I B Chatterjee, S D Gupta, A K Majumder, B K Nandi, N Subramanian
PMCID: PMC1348426  PMID: 52707

Abstract

1. In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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