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. 1975 Oct;252(1):97–113. doi: 10.1113/jphysiol.1975.sp011136

The effect of saline and hyperoncotic dextran infusion on canine ileal salt and water absorption and regional blood flow.

D Mailman, K Jordan
PMCID: PMC1348470  PMID: 1202200

Abstract

1. The unidirectional Na and H2O fluxes, vascular pressures and total and absorptive site blood flows in the canine ileum were determined before and during I.V. saline infusion and subsequent I.V. infusion of hyperoncotic dextran. The intestinal perfusion solutions were isotonic saline or isotonic saline and mannitol, but the effects of I.V. saline or I.V. hyperoncotic dextran infusion were generally the same for both luminal solutions. 2. Continuous I.V. infusion of saline caused a continuous increase in the unidirectional flux of Na and H2O into the ileal lumen, an increase in total blood flow, and an increase in venous pressure. 3. The net absorption of Na and H2O was decreased by I.V. saline infusion. 4. The unidirectional fluxes of Na and H2O out of the lumen, arterial pressure, and absorptive site blood flow were not affected by I.V. saline infusion. 5. I.V. hyperoncotic dextran infusion reversed most of the effects of saline infusion. 6. The unidirectional fluxes of Na and H2O into the lumen were significantly correlated with Starling forces during I.V. saline infusion. 7. It was concluded that intestinal transport of salt and water was subject to regulation by physical forces at the capillary level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGER E. Y., STEELE J. M. The calculation of transfer rates in two compartment systems not in dynamic equilibrium. J Gen Physiol. 1958 Jul 20;41(6):1135–1152. doi: 10.1085/jgp.41.6.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Daugharty T. M., Belleau L. J., Martino J. A., Earley L. E. Interrelationship of physical factors affecting sodium reabsorption in the dog. Am J Physiol. 1968 Dec;215(6):1442–1447. doi: 10.1152/ajplegacy.1968.215.6.1442. [DOI] [PubMed] [Google Scholar]
  3. Diamond J. M., Bossert W. H. Standing-gradient osmotic flow. A mechanism for coupling of water and solute transport in epithelia. J Gen Physiol. 1967 Sep;50(8):2061–2083. doi: 10.1085/jgp.50.8.2061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dobson A., Sellers A. F., Thorlacius S. O. Limitation of diffusion by blood flow through bovine ruminal epithelium. Am J Physiol. 1971 May;220(5):1337–1343. doi: 10.1152/ajplegacy.1971.220.5.1337. [DOI] [PubMed] [Google Scholar]
  5. Earley L. E., Friedler R. M. The effects of combined renal vasodilatation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium. J Clin Invest. 1966 Apr;45(4):542–551. doi: 10.1172/JCI105368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hakim A. A., Lifson N. Effects of pressure on water and solute transport by dog intestinal mucosa in vitro. Am J Physiol. 1969 Feb;216(2):276–284. doi: 10.1152/ajplegacy.1969.216.2.276. [DOI] [PubMed] [Google Scholar]
  7. Higgins J. T., Jr, Blair N. P. Intestinal transport of water and electrolytes during extracellular volume expansion in dogs. J Clin Invest. 1971 Dec;50(12):2569–2579. doi: 10.1172/JCI106757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Humphreys M. H., Earley L. E. The mechanism of decreased intestinal sodium and water absorption after acute volume expansion in the rat. J Clin Invest. 1971 Nov;50(11):2355–2367. doi: 10.1172/JCI106734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Imai M., Kokko J. P. Effect of peritubular protein concentration on reabsorption of sodium and water in isolated perfused proxmal tubules. J Clin Invest. 1972 Feb;51(2):314–325. doi: 10.1172/JCI106816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnson P. C. Autoregulation of blood flow in the intestine. Gastroenterology. 1967 Feb;52(2):435–441. [PubMed] [Google Scholar]
  11. Koch K. M., Aynedjian H. S., Bank N. Effect of acute hypertension on sodium reabsorption by the proximal tubule. J Clin Invest. 1968 Jul;47(7):1696–1709. doi: 10.1172/JCI105860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lundgren O., Svanvik J. Mucosal hemodynamics in the small intestine of the cat during reduced perfusion pressure. Acta Physiol Scand. 1973 Aug;88(4):551–563. doi: 10.1111/j.1748-1716.1973.tb05484.x. [DOI] [PubMed] [Google Scholar]
  13. Nutbourne D. M. The effect of small hydrostatic pressure gradients on the rate of active sodium transport across isolated living frog-skin membranes. J Physiol. 1968 Mar;195(1):1–18. doi: 10.1113/jphysiol.1968.sp008442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Richet G., Hornych A. The effect of an expansion of extracellular fluids on net Na flux in the jejunum of rats. An experimental model for the study of the third factor. Nephron. 1969;6(3):365–378. doi: 10.1159/000179739. [DOI] [PubMed] [Google Scholar]
  15. San Martin R., Mailman D. Effect of head upward tilting on unidirectional Na and H 2 O fluxes across the canine ileum. Proc Soc Exp Biol Med. 1972 Jun;140(2):694–699. doi: 10.3181/00379727-140-36533. [DOI] [PubMed] [Google Scholar]
  16. Svanvik J. Mucosal blood circulation and its influence on passive absorption in the small intestine. An experimental study in the cat. Acta Physiol Scand Suppl. 1973;385:1–44. [PubMed] [Google Scholar]
  17. Svanvik J. Mucosal hemodynamics in the small intestine of the cat during regional sympathetic vasoconstrictor activation. Acta Physiol Scand. 1973 Sep;89(1):19–29. doi: 10.1111/j.1748-1716.1973.tb05493.x. [DOI] [PubMed] [Google Scholar]
  18. WILSON T. H. A modified method for study of intestinal absorption in vitro. J Appl Physiol. 1956 Jul;9(1):137–140. doi: 10.1152/jappl.1956.9.1.137. [DOI] [PubMed] [Google Scholar]
  19. Wallentin I. Studies on intestinal circulation. Acta Physiol Scand Suppl. 1966;279:1–38. [PubMed] [Google Scholar]
  20. Winne D. The influence of blood flow and water net flux on the absorption of tritiated water from the jejunum of the rat. Naunyn Schmiedebergs Arch Pharmacol. 1972;272(4):417–436. doi: 10.1007/BF00501248. [DOI] [PubMed] [Google Scholar]

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