Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1975 Dec;253(1):37–52. doi: 10.1113/jphysiol.1975.sp011178

Calcium content and exchange in frog skeletal muscle.

A C Kirby, B D Lindley, J R Picken
PMCID: PMC1348531  PMID: 1082027

Abstract

Calcium content and exchange in frog ELD IV muscle were examined employing the efflux technique. 2. Muscle calcium was found to exchange with four time constants, 21-5 sec 2-7, 32 and 1244 min. 3. All calcium was found to be exchangeable with more than half the total amount residing in an extracellular compartment. 4. Results obtained from ELD IV muscles and single fibres were identical. 5. Muscle calcium content was found to remain constant up to 20 hr in vitro. 6. Extra exchange of calcium occurs upon contraction. This extra exchange appears to occur in the most slowly exchanging component. 7. The data are discussed in relation to morphological and autoradiographic findings and a model of calcium exchange in skeletal muscle is presented.

Full text

PDF
37

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianchi C. P., Bolton T. C. Effect of hypertonic solutions and "glycerol treatment" on calcium and magnesium movements of frog skeletal muscle. J Pharmacol Exp Ther. 1974 Mar;188(3):536–552. [PubMed] [Google Scholar]
  2. Borys H. K., Karler R. Effects of caffeine on the intracellular distribution of calcium in frog sartorius muscle. J Cell Physiol. 1971 Dec;78(3):387–404. doi: 10.1002/jcp.1040780308. [DOI] [PubMed] [Google Scholar]
  3. Curtis B. A. Calcium efflux from frog twitch muscle fibers. J Gen Physiol. 1970 Feb;55(2):243–253. [PubMed] [Google Scholar]
  4. FENN W. O., GILBERT D. L. Calcium equilibrium in muscle. J Gen Physiol. 1957 Jan 20;40(3):393–408. doi: 10.1085/jgp.40.3.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fuchs F., Briggs F. N. The site of calcium binding in relation to the activation of myofibrillar contraction. J Gen Physiol. 1968 May;51(5):655–676. doi: 10.1085/jgp.51.5.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HODGKIN A. L., KEYNES R. D. Active transport of cations in giant axons from Sepia and Loligo. J Physiol. 1955 Apr 28;128(1):28–60. doi: 10.1113/jphysiol.1955.sp005290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MILLIGAN J. V. THE TIME COURSE OF THE LOSS AND RECOVERY OF CONTRACTURE ABILITY IN FROG STRIATED MUSCLE FOLLOWING EXPOSURE TO CA-FREE SOLUTIONS. J Gen Physiol. 1965 May;48:841–858. doi: 10.1085/jgp.48.5.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Macdonald R. L., Mann J. E., Jr, Sperelakis N. Derivation of general equations describing tracer diffusion in any two-compartment tissue with application to ionic diffusion in cylindrical muscle bundles. J Theor Biol. 1974 May;45(1):107–130. doi: 10.1016/0022-5193(74)90046-0. [DOI] [PubMed] [Google Scholar]
  9. Moore L. E. Anion permeability of frog skeletal muscle. J Gen Physiol. 1969 Jul;54(1):33–52. doi: 10.1085/jgp.54.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SHANES A. M., BIANCHI C. P. Radiocalcium release by stimulated and potassium-treated sartorius muscles of the frog. J Gen Physiol. 1960 Jan;43:481–493. doi: 10.1085/jgp.43.3.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SHANES A. M., BIANCHI C. P. The distribution and kinetics of release of radiocalcium in tendon and skeletal muscle. J Gen Physiol. 1959 May 20;42(5):1123–1137. doi: 10.1085/jgp.42.5.1123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Weber A., Murray J. M. Molecular control mechanisms in muscle contraction. Physiol Rev. 1973 Jul;53(3):612–673. doi: 10.1152/physrev.1973.53.3.612. [DOI] [PubMed] [Google Scholar]
  13. Winegrad S. Intracellular calcium movements of frog skeletal muscle during recovery from tetanus. J Gen Physiol. 1968 Jan;51(1):65–83. doi: 10.1085/jgp.51.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Winegrad S. The intracellular site of calcium activaton of contraction in frog skeletal muscle. J Gen Physiol. 1970 Jan;55(1):77–88. doi: 10.1085/jgp.55.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES