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. 1969 Nov;205(2):317–327. doi: 10.1113/jphysiol.1969.sp008967

Indirect cholinergic vasomotor control of intestinal blood flow in the domestic chicken

Christopher Bell
PMCID: PMC1348604  PMID: 5357238

Abstract

1. A histochemical and pharmacological study has been made of the relationship between the medial circular and adventitial longitudinal smooth muscle coats of the anterior mesenteric artery of the domestic chicken.

2. The longitudinal (LM) coat was found to be innervated by excitatory cholinergic and inhibitory adrenergic nerves, confirming previous reports.

3. The circular (CM) coat was found to be innervated by adrenergic vasoconstrictor nerves. There was no evidence for the existence of cholinergic nerves supplying the circular muscle.

4. Contraction of the LM had little effect on the resting perfusion pressure of the isolated artery, but caused potentiation of perfusion pressure responses to vasoconstrictor stimuli directly affecting the CM.

5. It is suggested that the function of the LM is to modulate the reactivity of the anterior mesenteric artery to vasomotor stimuli, and that this may be particularly implicated in the cardiovascular response to sudden stress.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angelakos E. T., Bloomquist E. Release of norepinephrine from isolated hearts by acetylcholine. Arch Int Physiol Biochim. 1965 Jun;73(3):397–402. doi: 10.3109/13813456509081850. [DOI] [PubMed] [Google Scholar]
  2. BALL R. A., SAUTTER J. H., KATTER M. S. MORPHOLOGICAL CHARACTERISTICS OF THE ANTERIOR MESENTERIC ARTERY OF FOWL. Anat Rec. 1963 Jul;146:251–255. doi: 10.1002/ar.1091460311. [DOI] [PubMed] [Google Scholar]
  3. BRANDON K. W., BOYD H. Release of noradrenaline from the spleen of the cat by acetylcholine. Nature. 1961 Dec 2;192:880–881. doi: 10.1038/192880a0. [DOI] [PubMed] [Google Scholar]
  4. BULBRING E. Correlation between membrane potential, spike discharge and tension in smooth muscle. J Physiol. 1955 Apr 28;128(1):200–221. doi: 10.1113/jphysiol.1955.sp005299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bayliss W. M. On the local reactions of the arterial wall to changes of internal pressure. J Physiol. 1902 May 28;28(3):220–231. doi: 10.1113/jphysiol.1902.sp000911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bell C. Dual vasoconstrictor and vasodilator innervation of the uterine arterial supply in the guinea pig. Circ Res. 1968 Aug;23(2):279–289. doi: 10.1161/01.res.23.2.279. [DOI] [PubMed] [Google Scholar]
  7. Bell C. Effects of exogenous choline on adrenergic responses of the guinea-pig vas deferens. Br J Pharmacol Chemother. 1967 Jun;30(2):436–444. doi: 10.1111/j.1476-5381.1967.tb02150.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bell C. Fine structural localization of acetylcholinesterase at a cholinergic vasodilator nerve-arterial smooth muscle synapse. Circ Res. 1969 Jan;24(1):61–70. doi: 10.1161/01.res.24.1.61. [DOI] [PubMed] [Google Scholar]
  9. Bell C., McLean J. R. Localization of norepinephrine and acetylcholinesterase in separate neurons supplying the guinea-pig vas deferens. J Pharmacol Exp Ther. 1967 Jul;157(1):69–73. [PubMed] [Google Scholar]
  10. Bolton T. B. Electrical and mechanical activity of the longitudinal muscle of the anterior mesenteric artery of the domestic fowl. J Physiol. 1968 May;196(2):283–292. doi: 10.1113/jphysiol.1968.sp008507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bolton T. B. Studies on the longitudinal muscle of the anterior mesentric artery of the domestic fowl. J Physiol. 1968 May;196(2):273–281. doi: 10.1113/jphysiol.1968.sp008506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. FOLKOW B., SIVERTSSON R. ASPECTS OF THE DIFFERENCE IN VASCULAR 'REACTIVITY' BETWEEN CUTANEOUS RESISTANCE VESSELS AND A-V ANASTOMOSES. Angiologica. 1964;1:338–345. doi: 10.1159/000157600. [DOI] [PubMed] [Google Scholar]
  13. KARNOVSKY M. J., ROOTS L. A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem. 1964 Mar;12:219–221. doi: 10.1177/12.3.219. [DOI] [PubMed] [Google Scholar]
  14. Löffelholz K. Untersuchungen über die Noradrenalin-Freisetzung durch Acetylcholin am perfundierten Kaninchenherzen. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;258(2):108–122. [PubMed] [Google Scholar]
  15. Mellander S., Johansson B. Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol Rev. 1968 Sep;20(3):117–196. [PubMed] [Google Scholar]

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