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. 1969 Nov;205(2):393–403. doi: 10.1113/jphysiol.1969.sp008973

The role of brown adipose tissue in the calorigenic effect of adrenaline and noradrenaline in cold-acclimated rats

Jean Himms-Hagen
PMCID: PMC1348610  PMID: 5357247

Abstract

1. Removal of the interscapular brown adipose tissue of the cold-acclimated rat has no immediate effect on the calorigenic response of the rat to adrenaline or noradrenaline.

2. There is a progressive loss of the enhanced response to adrenaline and to noradrenaline during the 4 days following removal of the interscapular brown adipose tissue from cold-acclimated rats. There is no loss of response in sham-operated cold-acclimated rats.

3. Removal of the interscapular brown adipose tissue from rats living at room temperature has no effect on the calorigenic response to adrenaline or noradrenaline, neither immediately afterwards nor 2-4 days later.

4. It is concluded that interscapular brown adipose tissue is not the major site of oxygen consumption in the enhanced calorigenic response to adrenaline or noradrenaline in cold-acclimated rats. However, it does play an important role in this enhanced metabolic response, probably as an endocrine gland whose secretory product modifies the ability of other tissues to respond calorigenically to catecholamines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brück K., Wünnenberg W. Beziehung zwischen Thermogenese im "braunen" Fettgewebe, Temperatur im cervicalen Anteil des Vertebralkanals und Kältezittern. Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;290(2):167–183. [PubMed] [Google Scholar]
  2. DEPOCAS F., HART J. S., HEROUX O. Cold acclimation and the electromyogram of unanesthetized rats. J Appl Physiol. 1956 Nov;9(3):404–408. doi: 10.1152/jappl.1956.9.3.404. [DOI] [PubMed] [Google Scholar]
  3. DEPOCAS F. The calorigenic response of cold-acclimated white rats to infused noradrenaline. Can J Biochem Physiol. 1960 Feb;38:107–114. [PubMed] [Google Scholar]
  4. HSIEH A. C., CARLSON L. D. Role of adrenaline and noradrenaline in chemical regulation of heat production. Am J Physiol. 1957 Aug;190(2):243–246. doi: 10.1152/ajplegacy.1957.190.2.243. [DOI] [PubMed] [Google Scholar]
  5. Heim T., Hull D. The effect of propranalol on the calorigenic response in brown adipose tissue of new-born rabbits to catecholamines, glucagon, corticotrophin and cold exposure. J Physiol. 1966 Nov;187(2):271–283. doi: 10.1113/jphysiol.1966.sp008088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Himms-Hagen J. Sympathetic regulation of metabolism. Pharmacol Rev. 1967 Sep;19(3):367–461. [PubMed] [Google Scholar]
  7. Hull D., Segall M. M. The contribution of brown adipose tissue to heat production in the new-born rabbit. J Physiol. 1965 Dec;181(3):449–457. doi: 10.1113/jphysiol.1965.sp007773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Imai Y., Horwitz B. A., Smith R. E. Calorigenesis of brown adipose tissue in cold-exposed rats. Proc Soc Exp Biol Med. 1968 Mar;127(3):717–719. doi: 10.3181/00379727-127-32782. [DOI] [PubMed] [Google Scholar]
  9. JANSKY L. BODY ORGAN CYTOCHROME OXIDASE ACTIVITY IN COLD- AND WARM-ACCLIMATED RATS. Can J Biochem Physiol. 1963 Sep;41:1847–1854. [PubMed] [Google Scholar]
  10. JOHANSSON B. Brown fat: a review. Metabolism. 1959 May;8(3):221–240. [PubMed] [Google Scholar]
  11. Jansky L. Body organ thermogenesis of the rat during exposure to cold and at maximal metabolic rate. Fed Proc. 1966 Jul-Aug;25(4):1297–1305. [PubMed] [Google Scholar]
  12. Jansky L., Hart J. S. Cardiac output and organ blood flow in warm- and cold-acclimated rats exposed to cold. Can J Physiol Pharmacol. 1968 Jul;46(4):653–659. doi: 10.1139/y68-096. [DOI] [PubMed] [Google Scholar]
  13. Leduc J., Rivest P. Effets de l'ablation de la graisse brune interscapulaire sur l'acclimatation au froid chez le rat. Rev Can Biol. 1969 Mar;28(1):49–66. [PubMed] [Google Scholar]
  14. SMITH R. E., ROBERTS J. C. THERMOGENESIS OF BROWN ADIPOSE TISSUE IN COLD-ACCLIMATED RATS. Am J Physiol. 1964 Jan;206:143–148. doi: 10.1152/ajplegacy.1964.206.1.143. [DOI] [PubMed] [Google Scholar]
  15. SWANSON H. E. The effect of temperature on the potentiation of adrenalin by thyroxine in the albino rat. Endocrinology. 1957 Feb;60(2):205–213. doi: 10.1210/endo-60-2-205. [DOI] [PubMed] [Google Scholar]
  16. Smith R. E., Horwitz B. A. Brown fat and thermogenesis. Physiol Rev. 1969 Apr;49(2):330–425. doi: 10.1152/physrev.1969.49.2.330. [DOI] [PubMed] [Google Scholar]
  17. Wünnenberg W., Brück K. Single unit activity evoked by thermal stimulation of the cervical spinal cord in the guinea pig. Nature. 1968 Jun 29;218(5148):1268–1269. doi: 10.1038/2181268b0. [DOI] [PubMed] [Google Scholar]
  18. Wünnenberg W., Brück K. Zur Funktionsweise thermoreceptiver Strukturen im Cervicalmark des Meerschweinchens. Pflugers Arch Gesamte Physiol Menschen Tiere. 1968;299(1):1–10. [PubMed] [Google Scholar]

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