Correction to: Acta Pharmacologica Sinica 10.1038/s41401-025-01670-z, published online 01 November 2025
The authors would like to apologize for the errors in the published images of Figure 4a. We identified an error in Figure 4a, the NRG2 protein bands (Lable:NDRG1) for the NDRG1 overexpression group were inadvertently misplaced in panel a (NCI-H1975 cells), it was in duplicate with the NRG2 protein bands of Figure 4b (HCC827AR cells, Lable:NDRG1). Therefore, we kindly request that the NRG2 protein band in Figure 4a (Lable:NDRG1) are replaced by right one of the paper.
These corrections do not alter the conclusions of the paper. The authors sincerely apologize for any inconvenience caused to the journal and the readers.
The corrected Fig. 4 is shown below:
Fig. 4. Mag enhanced the NDRG1-HECW1-NRG2 complex, leading to the degradation of NRG2 in NSCLC.
Effects of overexpression of NDRG1 on NRG2 stability in NCI-H1975 (a) and HCC827AR (b) cells in the presence of 50 μM CHX at different time points. c, d Quantification of (a, b). Data are presented as mean ± SEM, n = 3. Protein levels of NRG2 in Mag-treated NCI-H1975 (Mag, 50 μM) and HCC827AR cells (Mag, 50 μM) in the presence of 10 μM CQ (e) or 0.1 μM MG132 (f). g Mass spectrometry analysis of Co-IP samples conducted with anti-NRG2 antibody in HCC827AR cells. Representative peptide sequence of the NRG2 protein (KEVGKILCTDCATRPKLK) was detected in HCC827AR. h Domains of human NRG2 and identified ubiquitination sites at K223, K238 and K240. Co-IP of NRG2 in NCI-H1975 (i) and HCC827AR (j) cells, followed by western blotting analysis for ubiquitination (UB). Different NRG2 mutants (K223R, K238R, K240R) are compared to Mock. Co-IP of NDRG1, HECW1 and NRG2 in NCI-H1975 (k) and HCC827AR (l) cells following treatment with 50 μM Mag for 15 h. m Structural model showing the interaction between NRG2, NDRG1, and HECW1 proteins. Co-IP of HECW1 and NRG2 in NCI-H1975 (n) and HCC827AR (o) cells following transfection with shNDRG1 for 15 h.
The original article has been corrected.