Abstract
Between January 1, 1981 and September 4, 1987, 407 cases of hemophilia-associated acquired immunodeficiency syndrome (AIDS) had been reported to the Centers for Disease Control. The number of cases diagnosed each year nearly doubled, except in 1986, when cases increased only 50 per cent. Demographic characteristics of the patients did not change over time. The majority (74 per cent) had severe hemophilia and 97 per cent received commercially produced concentrated clotting factors. The cumulative incidence of AIDS between 1981 and September 1987 for persons with severe hemophilia A was substantially greater than that for persons with severe hemophilia B (4.2 cases vs 1.9 cases per 100 persons).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronson D. L. Factor IX complex. Semin Thromb Hemost. 1979;6(1):28–43. doi: 10.1055/s-2007-1005094. [DOI] [PubMed] [Google Scholar]
- Gjerset G. F., McGrady G., Counts R. B., Martin P. J., Jason J., Kennedy S., Evatt B., Hansen J. A. Lymphadenopathy-associated virus antibodies and T cells in hemophiliacs treated with cryoprecipitate or concentrate. Blood. 1985 Sep;66(3):718–720. [PubMed] [Google Scholar]
- Goedert J. J., Sarngadharan M. G., Eyster M. E., Weiss S. H., Bodner A. J., Gallo R. C., Blattner W. A. Antibodies reactive with human T cell leukemia viruses in the serum of hemophiliacs receiving factor VIII concentrate. Blood. 1985 Feb;65(2):492–495. [PubMed] [Google Scholar]
- Kreiss J. K., Kitchen L. W., Prince H. E., Kasper C. K., Goldstein A. L., Naylor P. H., Preble O., Stewart J. A., Essex M. Human T cell leukemia virus type III antibody, lymphadenopathy, and acquired immune deficiency syndrome in hemophiliac subjects. Results of a prospective study. Am J Med. 1986 Mar;80(3):345–350. doi: 10.1016/0002-9343(86)90704-7. [DOI] [PubMed] [Google Scholar]
- Martin L. S., McDougal J. S., Loskoski S. L. Disinfection and inactivation of the human T lymphotropic virus type III/Lymphadenopathy-associated virus. J Infect Dis. 1985 Aug;152(2):400–403. doi: 10.1093/infdis/152.2.400. [DOI] [PubMed] [Google Scholar]
- McDougal J. S., Martin L. S., Cort S. P., Mozen M., Heldebrant C. M., Evatt B. L. Thermal inactivation of the acquired immunodeficiency syndrome virus, human T lymphotropic virus-III/lymphadenopathy-associated virus, with special reference to antihemophilic factor. J Clin Invest. 1985 Aug;76(2):875–877. doi: 10.1172/JCI112045. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Piszkiewicz D., Kingdom H., Apfelzweig R., McDougal J. S., Cort S. P., Andrews J., Hope J., Cabridilla C. D. Inactivation of HTLV-III/LAV during plasma fractionation. Lancet. 1985 Nov 23;2(8465):1188–1189. doi: 10.1016/s0140-6736(85)92710-2. [DOI] [PubMed] [Google Scholar]
- Ragni M. V., Tegtmeier G. E., Levy J. A., Kaminsky L. S., Lewis J. H., Spero J. A., Bontempo F. A., Handwerk-Leber C., Bayer W. L., Zimmerman D. H. AIDS retrovirus antibodies in hemophiliacs treated with factor VIII or factor IX concentrates, cryoprecipitate, or fresh frozen plasma: prevalence, seroconversion rate, and clinical correlations. Blood. 1986 Mar;67(3):592–595. [PubMed] [Google Scholar]
- Selik R. M., Starcher E. T., Curran J. W. Opportunistic diseases reported in AIDS patients: frequencies, associations, and trends. AIDS. 1987 Sep;1(3):175–182. [PubMed] [Google Scholar]
- Thomas D. G. Exact and asymptotic methods for the combination of 2 times 2 tables. Comput Biomed Res. 1975 Oct;8(5):423–446. doi: 10.1016/0010-4809(75)90048-8. [DOI] [PubMed] [Google Scholar]
- Waskin H., Smith K. J., Simon T. L., Gribble T. J., Mertz G. J. Prevalence of HTLV-III antibody among New Mexico residents with hemophilia. West J Med. 1986 Oct;145(4):477–480. [PMC free article] [PubMed] [Google Scholar]