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. 1989 Jul;79(7):832–835. doi: 10.2105/ajph.79.7.832

Survival analysis of hemophilia-associated AIDS cases in the US.

J K Stehr-Green 1, R C Holman 1, M A Mahoney 1
PMCID: PMC1349659  PMID: 2735467

Abstract

Using national hemophilia-associated AIDS (acquired immunodeficiency syndrome) surveillance data and the life table method of survival analysis, the median length of survival of hemophilic patients in the United States after the diagnosis of AIDS was 11.7 months; the cumulative probability of survival at one year was 49.2 +/- 2.0 percent; at two years, 28.9 +/- 2.3 percent. Patients 13-29 years of age at the time of diagnosis had the longest survival and those 60 years and older had the shortest. Patients diagnosed since 1986 survived longer than those diagnosed before 1986. Length of survival did not differ significantly by race, coagulation disorder, AIDS manifestation at the time of diagnosis, or region of residence. Seven patients survived more than 36 months after AIDS was diagnosed. These patients were similar to those surviving for a shorter duration except that they were more likely to have met only the 1987 revision of the Centers for Disease Control AIDS surveillance case definition (as opposed to the 1985 case definition). Results of this study suggest that survival among hemophilic patients after the diagnosis of AIDS is similar to that reported by other investigators for other AIDS risk groups, excluding patients with Kaposi's sarcoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ekert H. AIDS incubation period. Nature. 1987 Oct 8;329(6139):494–494. doi: 10.1038/329494a0. [DOI] [PubMed] [Google Scholar]
  2. Eyster M. E., Gail M. H., Ballard J. O., Al-Mondhiry H., Goedert J. J. Natural history of human immunodeficiency virus infections in hemophiliacs: effects of T-cell subsets, platelet counts, and age. Ann Intern Med. 1987 Jul;107(1):1–6. doi: 10.7326/0003-4819-107-1-1. [DOI] [PubMed] [Google Scholar]
  3. Fischl M. A., Dickinson G. M., La Voie L. Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS. JAMA. 1988 Feb 26;259(8):1185–1189. doi: 10.1001/jama.259.8.1185. [DOI] [PubMed] [Google Scholar]
  4. Fischl M. A., Richman D. D., Grieco M. H., Gottlieb M. S., Volberding P. A., Laskin O. L., Leedom J. M., Groopman J. E., Mildvan D., Schooley R. T. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med. 1987 Jul 23;317(4):185–191. doi: 10.1056/NEJM198707233170401. [DOI] [PubMed] [Google Scholar]
  5. Goedert J. J., Biggar R. J., Weiss S. H., Eyster M. E., Melbye M., Wilson S., Ginzburg H. M., Grossman R. J., DiGioia R. A., Sanchez W. C. Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science. 1986 Feb 28;231(4741):992–995. doi: 10.1126/science.3003917. [DOI] [PubMed] [Google Scholar]
  6. Kaplan L. D., Wofsy C. B., Volberding P. A. Treatment of patients with acquired immunodeficiency syndrome and associated manifestations. JAMA. 1987 Mar 13;257(10):1367–1374. [PubMed] [Google Scholar]
  7. Reeves G. K., Overton S. E. Preliminary survival analysis of UK AIDS data. Lancet. 1988 Apr 16;1(8590):880–880. doi: 10.1016/s0140-6736(88)91622-4. [DOI] [PubMed] [Google Scholar]
  8. Rothenberg R., Woelfel M., Stoneburner R., Milberg J., Parker R., Truman B. Survival with the acquired immunodeficiency syndrome. Experience with 5833 cases in New York City. N Engl J Med. 1987 Nov 19;317(21):1297–1302. doi: 10.1056/NEJM198711193172101. [DOI] [PubMed] [Google Scholar]
  9. Stehr-Green J. K., Holman R. C., Jason J. M., Evatt B. L. Hemophilia-associated AIDS in the United States, 1981 to September 1987. Am J Public Health. 1988 Apr;78(4):439–442. doi: 10.2105/ajph.78.4.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sullivan J. L., Brewster F. E., Brettler D. B., Forsberg A. D., Cheeseman S. H., Byron K. S., Baker S. M., Willitts D. L., Lew R. A., Levine P. H. Hemophiliac immunodeficiency: influence of exposure to factor VIII concentrate, LAV/HTLV-III, and herpesviruses. J Pediatr. 1986 Apr;108(4):504–510. doi: 10.1016/s0022-3476(86)80823-x. [DOI] [PubMed] [Google Scholar]
  11. Turner M. J., White J. O., Soutter W. P. AIDS incubation period in male haemophiliacs. Nature. 1987 Dec 24;330(6150):702–702. doi: 10.1038/330702a0. [DOI] [PubMed] [Google Scholar]
  12. Zagury D., Bernard J., Leonard R., Cheynier R., Feldman M., Sarin P. S., Gallo R. C. Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science. 1986 Feb 21;231(4740):850–853. doi: 10.1126/science.2418502. [DOI] [PubMed] [Google Scholar]

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