Abstract
We investigated physician awareness of the diagnosis of beta thalassemia minor as suggested by RBC indices obtained from routine electronic counts; and, the knowledge of the carriers of their genetic trait. Out of 17,000 counts, 324 were compatible with the diagnosis of beta thalassemia minor, but, only 175 (54 per cent) were identified by physicians as possibly thalassemic and in 47 of these (27 per cent) was the diagnosis verified. Twenty-four of 39 interviewed patients in whom the diagnosis of beta thalassemia minor was established knew about their carrier state.
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Selected References
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- Aghai E., Shabbad E., Quitt M., Froom P. Discrimination between iron deficiency and heterozygous beta-thalassemia in children. Am J Clin Pathol. 1986 Jun;85(6):710–712. doi: 10.1093/ajcp/85.6.710. [DOI] [PubMed] [Google Scholar]
- Borgna-Pignatti C., Zonta L., Bongo I., De Stefano P. Red blood cell indices in adults and children with heterozygous beta-thalassemia. Haematologica. 1983 Mar-Apr;68(2):149–156. [PubMed] [Google Scholar]
- Eliakim R., Rachmilewitz E. A. Hemoglobinopathies in Israel. Hemoglobin. 1983;7(5):479–485. doi: 10.3109/03630268309038420. [DOI] [PubMed] [Google Scholar]
- England J. M., Fraser P. M. Differentiation of iron deficiency from thalassaemia trait by routine blood-count. Lancet. 1973 Mar 3;1(7801):449–452. doi: 10.1016/s0140-6736(73)91878-3. [DOI] [PubMed] [Google Scholar]
- England J. M., Fraser P. Discrimination between iron-deficiency and heterozygous-thalassaemia syndromes in differential diagnosis of microcytosis. Lancet. 1979 Jan 20;1(8108):145–148. doi: 10.1016/s0140-6736(79)90532-4. [DOI] [PubMed] [Google Scholar]
- Hansen R. M., Hanson G., Anderson T. Failure to suspect and diagnose thalassemic syndromes. Interpretation of RBC indices by the nonhematologist. Arch Intern Med. 1985 Jan;145(1):93–94. [PubMed] [Google Scholar]
- Lipkin M., Jr, Fisher L., Rowley P. T., Loader S., Iker H. P. Genetic counseling of asymptomatic carriers in a primary care setting. The effectiveness of screening and counseling for beta-thalassemia trait. Ann Intern Med. 1986 Jul;105(1):115–123. doi: 10.7326/0003-4819-105-1-115. [DOI] [PubMed] [Google Scholar]
- Pearson H. A., O'Brien R. T., McIntosh S. Screening for thalassemia trait by electronic measurement of mean corpuscular volume. N Engl J Med. 1973 Feb 15;288(7):351–353. doi: 10.1056/NEJM197302152880706. [DOI] [PubMed] [Google Scholar]
- Rowley P. T. The diagnosis of beta-thalassemia trait: a review. Am J Hematol. 1976;1(1):129–137. doi: 10.1002/ajh.2830010115. [DOI] [PubMed] [Google Scholar]
- Schriever H. G. Red cell indices in thalassemia minor. Ann Clin Lab Sci. 1974 Sep-Oct;4(5):339–342. [PubMed] [Google Scholar]
- Shine I., Lal S. A strategy to detect beta-thalassaemia minor. Lancet. 1977 Mar 26;1(8013):692–694. doi: 10.1016/s0140-6736(77)92128-6. [DOI] [PubMed] [Google Scholar]
- Silvestroni E., Bianco I. A highly cost effective method of mass screening for thalassaemia. Br Med J (Clin Res Ed) 1983 Mar 26;286(6370):1007–1009. doi: 10.1136/bmj.286.6370.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ziegler F. D., Rich S. A., Gauvreau A. F., Grimley P. M., Stasiw D. M., Cerny L. C., Jaeger R. Population screening for beta-thalassemia minor. Report of cooperative trials based on two approaches. Am J Clin Pathol. 1978 Dec;70(6):861–866. doi: 10.1093/ajcp/70.6.861. [DOI] [PubMed] [Google Scholar]
