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. 1973 Apr;230(1):137–153. doi: 10.1113/jphysiol.1973.sp010179

Chronotropic and inotropic effects on the dog heart of stimulating the efferent cardiac sympathetic nerves

C M Furnival, R J Linden, H M Snow
PMCID: PMC1350390  PMID: 4702415

Abstract

1. The chronotropic and inotropic responses of the dog heart to stimulation of the ansae subclaviae were studied.

2. The maximum rate of rise of pressure in the left ventricle (dP/dt max) was used as an index of the inotropic changes.

3. In experiments in which the secondary inotropic effects of changes in heart rate and blood pressure were prevented it was shown that, using stimuli which produced the same chronotropic response, stimulation of the left ansa subclavia resulted in an inotropic change which was about eight times greater than that which resulted from stimulation of the right ansa subclavia.

4. In experiments in which heart rate and blood pressure were allowed to change freely it was shown that the secondary inotropic effects of changes in blood pressure and heart rate amounted to about 70% of the total inotropic change when the right ansa subclavia was stimulated and about 20% of the total change when the left ansa subclavia was stimulated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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