Abstract
Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 mN citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate.
1. Increase in concentration of sodium citrate in the range 0-125 mN gave increasing outputs of acid and chloride.
2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.
3. The greater the concentration of an acid citrate salt, the less the output of acid.
4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.
Full text
PDF













Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CODE C. F., WATKINSON G. Importance of vagal innervation in the regulatory effect of acid in the duodenum on gastric secretion of acid. J Physiol. 1955 Oct 28;130(1):233–252. doi: 10.1113/jphysiol.1955.sp005406. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chapman M. A., Werther J. L., Janowitz H. D. Response of the normal and pathological human gastric mucosa to an instilled acid load. Gastroenterology. 1968 Sep;55(3):344–353. [PubMed] [Google Scholar]
- HUNT J. N. Gastric emptying and secretion in man. Physiol Rev. 1959 Jul;39(3):491–533. doi: 10.1152/physrev.1959.39.3.491. [DOI] [PubMed] [Google Scholar]
- HUNT J. N. Influence of hydrochloric acid on gastric secretion and emptying in patients with duodenal ulcer. Br Med J. 1957 Mar 23;1(5020):681–684. doi: 10.1136/bmj.1.5020.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., KNOX M. T. The regulation of gastric emptying of meals containing citric acid and salts of citric acid. J Physiol. 1962 Aug;163:34–45. doi: 10.1113/jphysiol.1962.sp006957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., MACDONALD I. The relation between the volume of a test-meal and the gastric secretory response. J Physiol. 1952 Jul;117(3):289–302. doi: 10.1113/jphysiol.1952.sp004749. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N., MacDONALD I., SPURRELL W. R. The gastric response to pectin meals of high osmotic pressure. J Physiol. 1951 Oct 29;115(2):185–195. doi: 10.1113/jphysiol.1951.sp004663. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNT J. N. The secretory pattern of the stomach of man. J Physiol. 1951 Apr;113(2-3):169–184. doi: 10.1113/jphysiol.1951.sp004563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harding R., Leek B. F. Rapidly adapting mechanoreceptors in the reticulo-rumen which also respond to chemicals. J Physiol. 1972 May;223(1):32P–33P. [PubMed] [Google Scholar]
- Hunt J. N., Knox M. T. The slowing of gastric emptying by four strong acids and three weak acids. J Physiol. 1972 Apr;222(1):187–208. doi: 10.1113/jphysiol.1972.sp009793. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JOHNSTON D., DUTHIE H. L. EFFECT OF ACID IN THE DUODENUM ON HISTAMINE-STIMULATED GASTRIC SECRETION IN MAN. Gut. 1964 Dec;5:573–580. doi: 10.1136/gut.5.6.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOSTER K. H., RUNE S. J. ANTRAL CONTROL OF GASTRIC ACID SECRETION. Lancet. 1963 Dec 7;2(7319):1183–1187. doi: 10.1016/s0140-6736(63)92919-2. [DOI] [PubMed] [Google Scholar]
- OBRINK K. J. Bonedust-meat mixture as a test meal for continuous gastric secretion. Acta Physiol Scand. 1954;30(2-3):275–281. doi: 10.1111/j.1748-1716.1954.tb01095.x. [DOI] [PubMed] [Google Scholar]
- SAINT-HILAIRE S., LAVERS M. K., KENNEDY J., CODE C. F. Gastric acid secretory value of different foods. Gastroenterology. 1960 Jul;39:1–11. [PubMed] [Google Scholar]
- SCHMIDT F. R., HALLENBECK G. A. Effects of acid administered intragastrically on gastric acid in man; inhibitory effect on gastric secretion of acid in response to test meal. AMA Arch Surg. 1958 Jul;77(1):26–32. doi: 10.1001/archsurg.1958.01290010028006. [DOI] [PubMed] [Google Scholar]
- TAMARIT J., HUNT J. N., BOCK D., KIRSNER J. B. [Study of the composition of basal gastric juice in normal subjects]. Arch Med Exp. 1960;23:137–150. [PubMed] [Google Scholar]
- THAYSEN J. H., THORN N. A., SCHWARTZ I. L. Excretion of sodium, potassium, chloride and carbon dioxide in human parotid saliva. Am J Physiol. 1954 Jul;178(1):155–159. doi: 10.1152/ajplegacy.1954.178.1.155. [DOI] [PubMed] [Google Scholar]