Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1969 Feb;200(2):285–295. doi: 10.1113/jphysiol.1969.sp008693

The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly

D Bartošová, M Chvapil, B Korecký, O Poupa, K Rakušan, Z Turek, M Vízek
PMCID: PMC1350467  PMID: 4236906

Abstract

1. Cardiomegaly has been produced in rats by sideropenic anaemia, by isoprenaline or thyroxine or by the application of both drugs, by artificial increase in resistance to blood flow and by long-term adaptation to hypoxia and physical stress. The ratio of the growth of muscle to the growth of collagen in the heart has been studied.

2. All possible variations in the ratio occurred depending on the type of stimulus used for inducing cardiomegaly and on the dynamics of the development of cardiomegaly. In cardiomegaly induced by sideropenia and by thyroxine the growth of muscle was not accompanied by the growth of collagen. Exposure to hypoxia or isoprenaline administration increased only the growth of collagen in the hypertrophic heart. In all other forms of cardiomegaly muscle and collagen formation were stimulated to the same extent.

3. It is concluded that when certain organs hypertrophy during adult life several factors may determine the relative rapidity of growth of the muscular or parenchymal and the collagenous stromal components of the tissue.

Full text

PDF
285

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BETKE K., SAVELSBERG W. Stufenphotometrische Hämoglobinbestimmung mittels Cyanhämiglobin. Biochem Z. 1950;320(5):431–439. [PubMed] [Google Scholar]
  2. BEZNAK M. Cardiovascular effects of thyroxine treatment in normal rats. Can J Biochem Physiol. 1962 Dec;40:1647–1654. [PubMed] [Google Scholar]
  3. BEZNAK M., HACKER P. IMMEDIATE HEMODYNAMIC EFFECTS OF ISOPROTERENOL. Can J Biochem Physiol. 1963 Sep;41:1949–1953. [PubMed] [Google Scholar]
  4. BEZNAK M. The effect of the pituitary and growth hormone on the blood pressure and on the ability of the heart to hypertrophy. J Physiol. 1952 Jan 28;116(1):74–83. doi: 10.1113/jphysiol.1952.sp004690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brada Z. Host--tumour relationship. XX. The hexosamine content of the tumour as a marker of relations between the tumour stroma and tumour cells. Neoplasma. 1965;12(4):373–378. [PubMed] [Google Scholar]
  6. Chvapil M., Hurych J. Control of collagen biosynthesis. Int Rev Connect Tissue Res. 1968;4:67–196. doi: 10.1016/b978-1-4831-6754-1.50010-8. [DOI] [PubMed] [Google Scholar]
  7. Chvapil M., Hurych J., Ehrlichová E., Tichý M. Mechanism of the action of chelating agents on proline hydroxylation and its incorporation into collagenous and non-collagenous proteins. Eur J Biochem. 1967 Sep;2(2):229–235. doi: 10.1111/j.1432-1033.1967.tb00129.x. [DOI] [PubMed] [Google Scholar]
  8. Chvapil M., Rakusan K., Wachtlová M., Poupa O. Collagen in the heart of wild and domesticated animals. Gerontologia. 1966;12(3):144–154. doi: 10.1159/000211546. [DOI] [PubMed] [Google Scholar]
  9. FULTON R. M., HUTCHINSON E. C., JONES A. M. Ventricular weight in cardiac hypertrophy. Br Heart J. 1952 Jul;14(3):413–420. doi: 10.1136/hrt.14.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HARKNESS M. L., HARKNESS R. D. Further observations on collagen in regenerating liver of the rat. J Physiol. 1954 Mar 29;123(3):482–491. doi: 10.1113/jphysiol.1954.sp005065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HARKNESS M. L., HARKNESS R. D., MORALEE B. E. The effect of the oestrous cycle and of hormones on the collagen content of the uterus of the rat. J Physiol. 1957 Feb 15;135(2):270–280. doi: 10.1113/jphysiol.1957.sp005709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HARKNESS M. L., HARKNESS R. D., SANTLER J. E. Changes in the collagen content of the thyroid in rats treated with thiouracil. J Physiol. 1954 Jul 28;125(1):51–55. doi: 10.1113/jphysiol.1954.sp005141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HARKNESS M. L., HARKNESS R. D. The collagen content of the liver in pregnancy and lactation. J Physiol. 1956 Oct 29;134(1):135–138. doi: 10.1113/jphysiol.1956.sp005629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HARKNESS M. L., HARKNESS R. D. The effect of pregnancy and lactation on the collagen content of the mammary gland of the rat. J Physiol. 1956 Jun 28;132(3):476–481. doi: 10.1113/jphysiol.1956.sp005540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HARKNESS R. D. Collagen in regenerating liver of the rat. J Physiol. 1952 Jul;117(3):257–266. doi: 10.1113/jphysiol.1952.sp004746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. HURYCH J., SHVAPIL M. INFLUENCE OF CHELATING AGENTS ON THE BIOSYNTHESIS OF COLLAGEN. Biochim Biophys Acta. 1965 Feb 15;97:361–363. doi: 10.1016/0304-4165(65)90108-x. [DOI] [PubMed] [Google Scholar]
  17. KORECKY B., RAKUSAN K., POUPA O. THE EFFECT OF ANAEMIA DUE TO IRON DEFICIENCY DURING EARLY POSTNATAL DEVELOPMENT OF THE RAT ON GROWTH AND BODY COMPOSITION LATER IN LIFE. Physiol Bohemoslov. 1964;13:72–77. [PubMed] [Google Scholar]
  18. MEERSON F. Z. A MECHANISM OF HYPERTROPHY AND WEAR OF THE MYOCARDIUM. Am J Cardiol. 1965 Jun;15:755–760. doi: 10.1016/0002-9149(65)90377-2. [DOI] [PubMed] [Google Scholar]
  19. MONTFORT I., PEREZ-TAMAYO R. The muscle-collagen ratio in normal and hypertrophic human hearts. Lab Invest. 1962 Jun;11:463–470. [PubMed] [Google Scholar]
  20. OKEN D. E., BOUCEK R. J. Quantitation of collagen in human myocardium. Circ Res. 1957 Jul;5(4):357–361. doi: 10.1161/01.res.5.4.357. [DOI] [PubMed] [Google Scholar]
  21. POUPA O., KROFTA K., PROCHAZKA J., CHVAPIL M. THE RESISTANCE OF THE MYOCARDIUM TO ANOXIA IN ANIMALS ACCLIMATED TO SIMULATED ALTITUDE. Physiol Bohemoslov. 1965;14:233–237. [PubMed] [Google Scholar]
  22. Poupa O., Turek Z., Kalus M., Krofta K. Acute cardiac infarct like necrosis in high altitude adapted rats. Physiol Bohemoslov. 1965;14(6):542–545. [PubMed] [Google Scholar]
  23. RAKUSAN K., KORECKY B., ROTH Z., POUPA O. DEVELOPMENT OF THE VENTRICULAR WEIGHT OF THE RAT HEART WITH SPECIAL REFERENCE TO THE EARLY PHASES OF POSTNATAL ONTOGENESIS. Physiol Bohemoslov. 1963;12:518–525. [PubMed] [Google Scholar]
  24. Rakusan K., Poupa O. Differences in capillary supply of hypertrophic and hyperplastic hearts. Cardiologia. 1966;49(5):293–298. doi: 10.1159/000168934. [DOI] [PubMed] [Google Scholar]
  25. Rakusan K., Tietzová H., Poupa O., Turek Z. Cardiomegaly after repeated application of isoprenalin in the rat. Physiol Bohemoslov. 1965;14(5):456–459. [PubMed] [Google Scholar]
  26. STEGEMANN H. Mikrobestimmung von Hydroxyprolin mit Chloramin-T und p-Dimethylaminobenzaldehyd. Hoppe Seylers Z Physiol Chem. 1958;311(1-3):41–45. [PubMed] [Google Scholar]
  27. STRUBELT O., BREINING H. ZUR PATHOGENESE UND PHARMAKOLOGISCHEN BEEINFLUSSUNG DER DURCH ISOPRENALIN-VERGIFTUNG HERVORGERUFENEN MYOCARDNEKROSEN. Arzneimittelforschung. 1964 Nov;14:1196–1198. [PubMed] [Google Scholar]
  28. Turek Z., Vízek M., Rakusan K., Poupa O. Cardiomegaly in rats after repeated administration of isoprenaline and thyroidin. Physiol Bohemoslov. 1968;17(1):43–47. [PubMed] [Google Scholar]
  29. VECCHIONI R., TARTARINI A. [Behavior of collagen fractions in muscular hypertrophy]. Boll Soc Ital Biol Sper. 1960 Dec 31;36:1415–1417. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES