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. 1973 Aug;232(3):485–501. doi: 10.1113/jphysiol.1973.sp010282

Placental iron transfer in the cat

Erica Baker, E H Morgan
PMCID: PMC1350505  PMID: 4759679

Abstract

1. The transfer of iron from maternal plasma to the foetus was studied in the cat using cat transferrin labelled with 59Fe and radioiodine.

2. Pregnancy was accompanied by a fall in maternal haematocrit, a rise in serum total iron-binding capacity and iron stores, but no change in serum iron concentration or plasma iron turnover.

3. Near-term foetal haematocrit and serum iron concentration were higher and iron binding capacity lower than in the pregnant animals.

4. The uptake of 59Fe from maternal plasma by the placenta and transfer to the foetuses were slow and small in amount. The daily transfer of iron to the foetuses calculated from these data was only 5 μg.

5. There was a small, transient uptake of 59Fe from the plasma by the foetal membranes.

6. Small amounts of plasma transferrin and albumin were slowly taken up by the placenta.

7. It was concluded that the maternal endothelium of the placenta of the cat acts as a barrier for the uptake of plasma transferrin-bound iron. As a result the rate of iron transfer to the foetuses from maternal plasma is inadequate to account for their rate of iron accumulation, and another source, such as maternal erythrocytes, must supply most of the iron to the foetuses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMOROSO E. C. Histology of the placenta. Br Med Bull. 1961 May;17:81–90. doi: 10.1093/oxfordjournals.bmb.a069901. [DOI] [PubMed] [Google Scholar]
  2. BOTHWELL T. H., PRIBILLA W. F., MEBUST W., FINCH C. A. Iron metabolism in the pregnant rabbit; iron transport across the placenta. Am J Physiol. 1958 Jun;193(3):615–622. doi: 10.1152/ajplegacy.1958.193.3.615. [DOI] [PubMed] [Google Scholar]
  3. Baker E., Morgan E. H. The role of transferrin in placental iron transfer in the rabbit. Q J Exp Physiol Cogn Med Sci. 1969 Apr;54(2):173–186. doi: 10.1113/expphysiol.1969.sp002015. [DOI] [PubMed] [Google Scholar]
  4. Baker E., Shaw D. C., Morgan E. H. Isolation and characterization of rabbit serum and milk transferrins. Evidence for difference in sialic acid content only. Biochemistry. 1968 Apr;7(4):1371–1378. doi: 10.1021/bi00844a019. [DOI] [PubMed] [Google Scholar]
  5. DAVIES J., BROWN E. B., Jr, STEWART D., TERRY C. W., SISSON J. Transfer of radioactive iron via the placenta and accessory fetal membranes in the rabbit. Am J Physiol. 1959 Jul;197(1):87–92. doi: 10.1152/ajplegacy.1959.197.1.87. [DOI] [PubMed] [Google Scholar]
  6. DEMPSEY E. W., WISLOCKI G. B. Electron microscopic observations on the placenta of the cat. J Biophys Biochem Cytol. 1956 Nov 25;2(6):743–754. doi: 10.1083/jcb.2.6.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DUKES P. P., GOLDWASSER E. Inhibition of erythropoiesis by estrogens. Endocrinology. 1961 Jul;69:21–29. doi: 10.1210/endo-69-1-21. [DOI] [PubMed] [Google Scholar]
  8. Drabkin D. L. The hemophagous organ of the placenta and in vitro studies of endogenous carbon monoxide production. Ann N Y Acad Sci. 1970 Oct 5;174(1):49–63. doi: 10.1111/j.1749-6632.1970.tb49771.x. [DOI] [PubMed] [Google Scholar]
  9. Fletcher J., Suter P. E. The transport of iron by the human placenta. Clin Sci. 1969 Apr;36(2):209–220. [PubMed] [Google Scholar]
  10. GITLIN D., KUMATE J., URRUSTI J., MORALES C. THE SELECTIVITY OF THE HUMAN PLACENTA IN THE TRANSFER OF PLASMA PROTEINS FROM MOTHER TO FETUS. J Clin Invest. 1964 Oct;43:1938–1951. doi: 10.1172/JCI105068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Glasser S. R., Wright C., Heyssel R. M. Transfer of iron across the placenta and fetal membranes in the rat. Am J Physiol. 1968 Jul;215(1):205–210. doi: 10.1152/ajplegacy.1968.215.1.205. [DOI] [PubMed] [Google Scholar]
  12. Jepson J. H., Lowenstein L. Inhibition of the stem cell action of erythropoietin by estradiol valerate and the protective effects of 17-alpha-hydroxyprogesterone caproate and testosterone propionate. Endocrinology. 1967 Mar;80(3):430–434. doi: 10.1210/endo-80-3-430. [DOI] [PubMed] [Google Scholar]
  13. KALDOR I. Studies on intermediary iron metabolism. V. The measurement of non-haemoglobin tissue iron. Aust J Exp Biol Med Sci. 1954 Dec;32(6):795–799. doi: 10.1038/icb.1954.82. [DOI] [PubMed] [Google Scholar]
  14. LAURELL C. B., MORGAN E. IRON EXCHANGE BETWEEN TRANSFERRIN AND THE PLACENTA IN THE RAT. Acta Physiol Scand. 1964 Nov;62:271–279. doi: 10.1111/j.1748-1716.1964.tb03974.x. [DOI] [PubMed] [Google Scholar]
  15. Lane R. S. Regulating factors in the transfer of iron across the rat placenta. Br J Haematol. 1968 Oct;15(4):365–369. doi: 10.1111/j.1365-2141.1968.tb01551.x. [DOI] [PubMed] [Google Scholar]
  16. Larkin E. C., Weintraub L. R., Crosby W. H. Iron transport across rabbit allantoic placenta. Am J Physiol. 1970 Jan;218(1):7–11. doi: 10.1152/ajplegacy.1970.218.1.7. [DOI] [PubMed] [Google Scholar]
  17. MORGAN E. H., CARTER G. Plasma iron and iron-binding capacity levels in health and disease: with an improved method for the estimation of plasma iron concentration and total iron-binding capacity. Australas Ann Med. 1960 Aug;9:209–213. doi: 10.1111/imj.1960.9.3.209. [DOI] [PubMed] [Google Scholar]
  18. MORGAN E. H. PASSAGE OF TRANSFERRIN, ALBUMIN AND GAMMA GLOBULIN FROM MATERNAL PLASMA TO FOETUS IN THE RAT AND RABBIT. J Physiol. 1964 May;171:26–41. doi: 10.1113/jphysiol.1964.sp007359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Masters C. L., Bignold L. P., Morgan E. H. Plasma protein metabolism and transfer to the fetus during pregnancy in the rat. Am J Physiol. 1969 Apr;216(4):876–883. doi: 10.1152/ajplegacy.1969.216.4.876. [DOI] [PubMed] [Google Scholar]
  20. McCANCE R. A., WIDDOWSON E. M. The metabolism of iron during suckling. J Physiol. 1951 Feb;112(3-4):450–458. doi: 10.1113/jphysiol.1951.sp004543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. VOSBURGH G. J., FLEXNER L. B. Maternal plasma as a source of iron for the fetal guinea pig. Am J Physiol. 1950 May;161(2):202–211. doi: 10.1152/ajplegacy.1950.161.2.202. [DOI] [PubMed] [Google Scholar]
  22. WARNER G. T., OLIVER R. A plastic phosphor well counter for sample volumes up to 400 ml. Br J Radiol. 1962 May;35:349–352. doi: 10.1259/0007-1285-35-413-349. [DOI] [PubMed] [Google Scholar]

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