Table V.

Interaction between genotype and smoking by gender

	Male			Female		All Subjects
Genotype	Smoking (pky)	Case/Con n/n	OR (95% CI)*	Case/Con n/n	OR (95% CI)*	OR (95% CI)*
CYP1A2*1D
T/T	NS	36/33	1.0	28/41	1.0	1.0
T/delT & delT/delT	NS	27/31	0.9 (0.4–1.6)	22/43	0.8 (0.4–1.8)	0.8 (0.4–1.3)
T/T	≤20	20/29	0.6 (0.3–1.4)	18/13	2.2 (0.8–5.5)	1.1 (0.6–1.9)
T/delT & delT/delT	≤20	19/21	0.7 (0.3–1.5)	17/20	1.3 (0.5–3.2)	1.0 (0.5–1.7)
T/T	>20	45/29	1.1 (0.5–2.3)	17/13	1.7 (0.6–4.3)	1.4 (0.8–2.4)
T/delT & delT/delT	>20	36/33	1.0 (0.4–1.9)	19/10	3.1 (1.0–8.0)	1.4 (0.7–2.3)
CYP1A2*1F
AA	NS	26/27	1.0	25/48	1.0	1.0
AC/CC	NS	36/38	0.9 (0.4–1.8)	26/38	1.3 (0.6–2.9)	1.1 (0.7–1.9)
AA	≤20	16/23	0.6 (0.3–1.5)	15/17	2.1 (0.8–5.2)	1.2 (0.6–2.2)
AC/CC	≤20	22/27	0.7 (0.3–1.6)	21/16	2.5 (1.0–6.2)	1.3 (0.7–2.3)
AA	>20	34/28	1.1 (0.5–2.3)	13/13	2.0 (0.7–5.6)	1.5 (0.8–2.7)
AC/CC	>20	47/34	1.1 (0.5–2.4)	23/11	3.8 (1.5–10.1)	1.9 (1.1–3.4)
NAT1
Reference	NS	37/46	1.0	28/58	1.0	1.0
Rapid	NS	25/15	2.1 (0.9–4.7)	24/24	2.2 (1.0–4.9)	2.2 (1.2–3.7)
Reference	≤20	27/27	1.2 (0.6–2.4)	21/21	2.1 (0.8–5.1)	1.7 (0.9–2.8)
Rapid	≤20	10/21	0.4 (0.1–1.1)	13/12	2.6 (1.0–7.1)	1.0 (0.5–2.0)
Reference	>20	47/43	1.1 (0.6–2.1)	23/15	3.0 (1.2–7.3)	1.7 (1.0–2.7)
Rapid	>20	31/17	2.1 (1.0–4.6)	16/8	4.5 (1.6–12.7)	3.0 (1.6–5.4)
NAT2
Rapid & intermediate	NS	23/23	1.0	24/35	1.0	1.0
Slow	NS	32/35	1.0 (0.4–2.1)	28/47	0.9 (0.4–2.0)	0.9 (0.5–1.6)
Rapid & intermediate	≤20	12/21	0.5 (0.2–1.3)	11/13	1.2 (0.4–3.6)	0.7 (0.4–1.5)
Slow	≤20	20/25	0.7 (0.3–1.8)	22/19	1.9 (0.7–4.3)	1.2 (0.6–2.2)
Rapid & intermediate	>20	29/26	1.0 (0.5–2.4)	14/9	2.2 (0.7–6.7)	1.5 (0.8–2.7)
Slow	>20	42/36	1.1 (0.5–2.6)	21/14	2.0 (0.8–5.1)	1.5 (0.8–2.6)

^*Obtained from a logistical regression model with adjustment for age, diabetes, pancreatitis and ethanol intake (all as categorical variables).