ABSTRACT
Background and Aims
Access to healthcare remains a major challenge in low‐ and middle‐income countries, including Ethiopia, where financial and geographic barriers limit service utilization. Community‐Based Health Insurance (CBHI) has been introduced to enhance financial protection and improve healthcare access. This study examined factors associated with women's perceptions of CBHI in improving healthcare access in the Sidama Region, Southern Ethiopia, in 2024.
Methods
A community‐based cross‐sectional study was conducted among women using a multistage stratified sampling approach. Data were collected through face‐to‐face interviews using the KoBoTool platform. Multilevel logistic regression analysis using Stata 18 examined individual‐ and community‐level determinants of women's perceptions of healthcare access. Adjusted odds ratios (AORs) with 95% confidence intervals were reported. Statistical significance was set at p < 0.05.
Results
Of 845 women sampled, 835 (98.8%) were interviewed. Women residing in low‐poverty communities had significantly higher odds of perceiving improved access compared to those in high‐poverty areas (AOR = 4.6; 95% CI: 1.8–9.1). Rural residents were less likely to report improvements than urban residents (AOR = 0.37; 95% CI: 0.18–0.68). Recent health facility visits increased positive perceptions more than fourfold (AOR = 4.1; 95% CI: 1.9–8.2), whereas missed visits reduced the likelihood by 45% (AOR = 0.55; 95% CI: 0.34–0.88). Perceived inadequacy of the CBHI package and unfair contributions were associated with substantially lower odds of positive perception. Acceptance of CBHI emerged as the strongest predictor (AOR = 6.3; 95% CI: 2.1–13.6).
Conclusion
Women's perceptions of CBHI are shaped by socioeconomic conditions, residence, healthcare utilization, and views on fairness and adequacy. Strengthening equitable and culturally responsive CBHI implementation may enhance healthcare access in Ethiopia and similar settings.
Keywords: community‐based health insurance, Ethiopia, healthcare access, multilevel analysis, women's perceptions
1. Introduction
Access to quality healthcare remains a major challenge worldwide. Many countries struggle to ensure fair access for all. In low‐ and middle‐income countries, high out‐of‐pocket payments create heavy financial burdens. These costs affect vulnerable groups the most, especially women, who often have limited control over household finances [1]. Paying directly for care can prevent people from seeking treatment. It also slows progress toward Universal Health Coverage (UHC). UHC ensures that everyone can use the health services they need without facing financial hardship. Achieving this goal requires strong, sustainable financing systems that protect households from catastrophic health costs [1].
Community‐based health insurance (CBHI) is one way countries like Ethiopia move toward UHC. CBHI is voluntary, locally managed, and designed to protect poor households. Unlike Social Health Insurance, which is mandatory for formal‐sector workers, or private insurance, which is profit‐oriented, CBHI is community‐driven [2]. In Ethiopia, it was introduced in 2011 as part of broader health financing reforms. Premiums are set affordably, often 200–400 Birr per year, about 5%–10% of the minimum monthly wage. Poorer households may pay less or be exempted [3]. The benefit package usually covers basic outpatient and inpatient services at public facilities. While not comprehensive, CBHI protects against common illnesses that could otherwise cause catastrophic costs [4].
Across sub‐Saharan Africa, CBHI has become an important strategy to reduce financial hardship and expand healthcare access [5]. Rwanda provides a successful example, with high coverage driven by political commitment. Other countries face persistent challenges, including financial sustainability, weak administrative capacity, and inconsistent service quality [6]. In Ethiopia, the program has expanded with government support, particularly targeting informal‐sector and marginalized households. Premium contributions are linked to income, which ensures fairness, though affordability and service quality remain concerns [7].
Women's participation in CBHI is influenced by education, autonomy, and household income [8]. Women are central to household health decisions but face unique barriers, including limited financial resources, cultural norms, and restricted mobility [9]. In the Sidama Region, Central Zone, CBHI enrollment among women has increased, but their perceptions of service quality, provider attitudes, and health infrastructure remain underexplored [10]. Understanding these perceptions is essential for designing policies that meet women's needs.
This study draws on health insurance theory and risk aversion theory from health economics. These theories suggest that households seek insurance to avoid unexpected financial hardship. High out‐of‐pocket payments motivate enrollment in schemes like CBHI. Women are sensitive to affordability. To lower direct payments and to offer subsidized premiums for poorer households, CBHI influences women's decisions to seek healthcare. This framework helps explain how CBHI shapes women's perceptions of access, satisfaction, and continuity of care [11].
We also applied the Donabedian framework to examine healthcare quality. It considers structure (facilities, staff, equipment), process (provider–patient interactions), and outcomes (health, satisfaction, equity) [12]. These dimensions shape how women perceive care quality. Weak infrastructure or poor provider attitudes can reduce trust, while supportive processes and well‐resourced facilities improve satisfaction and reinforce positive outcomes [13].
A conceptual model links CBHI enrollment, socio‐demographic factors (education, autonomy, income), and perceived quality. Enrollment provides access. Moderators influence participation and perception. Perceived quality affects satisfaction, continued participation, and trust. Together, these frameworks capture both service features and social influences on women's experiences under CBHI [14].
Evidence from Sidama shows that 35% of women were enrolled in CBHI in 2024, a rate higher than regional and some national averages. Enrolled women reported better access, lower out‐of‐pocket spending, and higher satisfaction than uninsured peers [8]. Challenges remain, including inconsistent service quality and coverage below national targets. A 2023 pilot program introduced sliding‐scale premiums to improve fairness and affordability [15].
Most studies focus narrowly on enrollment and service use, often using methods that ignore hierarchical data. Few examine specific domains of healthcare quality or socio‐demographic moderators [16]. Without such insights, policymakers cannot design CBHI reforms that fully meet women's needs. This gap threatens the program's sustainability and effectiveness [17].
This study addresses the gap by examining women's perceptions of healthcare quality under CBHI in Sidama. It focuses on three domains: accessibility, satisfaction, and treatment outcomes. By situating CBHI in Ethiopia's health financing history and applying relevant frameworks, the study provides evidence to improve CBHI design. Findings contribute to equity, support UHC goals, and inform policies that strengthen financial protection while enhancing healthcare quality for women.
2. Methods
2.1. Study Setting
This study analyzed primary data from research conducted in the Central Zone of the Sidama Region, Ethiopia, a regional state established in June 2020 [18]. The zone comprises six districts and one town administration, with a total population of 956,967 [19]. Dale Woreda and Yirgalem City Administration, located approximately 45 km south of Hawassa, the regional capital, were selected as study sites [20]. These sites were purposively chosen to represent both urban and rural settings in the Central Zone of Sidama. Both areas have well‐established CBHI programs with sufficient enrollment, allowing us to examine women's perceptions across diverse socio‐demographic and geographic contexts. Selecting these sites ensured the study was feasible, relevant, and capable of generating findings that can inform local and regional health policy [21].
2.2. Study Design and Period
A community‐based cross‐sectional study was conducted from December 15, 2023, to January 12, 2024, following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist (Supplementary File 1).Source and study population
The source population comprised all women aged ≥ 18 years residing in Dale Woreda and Yirgalem City Administration. Inclusion required continuous residence for at least 1 year to ensure adequate exposure to local healthcare systems. Women unable to communicate due to illness or cognitive impairment, temporarily absent during data collection, recent visitors, or those unable to provide informed consent were excluded, in line with STROBE methodological and ethical standards [22].
2.3. Sample Size and Sampling Method
The sample size was calculated using OpenEpi 3, based on a prior CBHI coverage of 49% in Tigray [8, 23]. Using a 5% margin of error and 95% confidence level. Applying a design effect of 2 [24] to account for clustering produced 768, based on an intraclass correlation coefficient (ICC) of 0.01 [25]. Fourteen kebeles (the lowest administrative unit in Ethiopia) were selected to enhance statistical power and representativeness, maintaining design effect at 2 [26]. Allowing for a 10% non‐response rate, the final sample size was 845.
The study employed a multistage sampling approach. Yirgalem City and Dale Woreda were purposively selected based on their relevance to the study objectives. Within each Woreda, kebeles (the smallest administrative units) were randomly selected as clusters. Fourteen kebeles were included: nine from Dale Woreda (eight rural, one urban) and five from Yirgalem City Administration (three rural, two urban). Random selection minimized bias and enhanced representativeness.
The total sample was proportionally allocated to each kebele according to population size, with eligible women per kebele ranging from 873 to 2192. As full cluster sampling was not feasible, simple random sampling was applied to lists of eligible women obtained from community health records to achieve the required sample size. At the household level, simple random sampling was again used to select households. Data collectors approached selected households to identify eligible women, prioritizing women due to their central role in household health decisions. Where more than one eligible woman was present, one was selected using a lottery method to ensure fairness. Up to three contact attempts were made for initially unavailable households, and visit details were documented to maintain data quality and accountability.
2.4. Study Variables
Variable selection was guided by Health Insurance Theory and Donabedian's Framework to capture both financial protection and healthcare quality dimensions.
2.4.1. Outcome Variable
The primary outcome was women's perception of whether CBHI improves healthcare access. Participants were asked whether they believed CBHI enhances access to healthcare services in their community. Responses were coded as 1 (“Yes”) and 0 (“No”). This binary measure reflects the theoretical premise that financial risk protection reduces barriers and facilitates timely care‐seeking.
2.4.2. Individual‐Level Variables
Individual factors included socioeconomic status, demographic characteristics, and CBHI‐related variables such as enrollment status, premium affordability, benefit awareness, and women's financial autonomy. These variables align with Health Insurance Theory, which emphasizes affordability, equity, and the role of financial protection in shaping healthcare utilization.
2.4.3. Community‐Level Variables
Community‐level factors comprised residence (urban/rural), women's literacy, community poverty, and autonomy. In line with Donabedian's framework, these variables reflect structural and contextual determinants that may influence how CBHI operates within healthcare systems and moderates access outcomes. Detailed variable definitions and measurements are provided in Supplementary File S2.
2.5. Data Collection and Quality Assurance
A structured, pre‐tested questionnaire (Supplementary File S3), adapted from validated sources [27, 28], was used for data collection. The questionnaire was translated into Sidaamu Afoo and subsequently back‐translated into English to ensure accuracy, consistency, and originality. A pretest involving 5% of the sample was conducted in Hitata kebele, resulting in refinement of the tool and demonstrating high internal consistency (Cronbach's α = 0.90). Data were collected through face‐to‐face interviews using the KoBoTool mobile platform by 25 trained health science graduates, under the supervision of five master level public health professionals [29]. Daily data quality checks were performed to ensure completeness and validity. Before analysis, the dataset underwent comprehensive preprocessing, including verification of coding accuracy, data cleaning, and management of missing data through exclusion when imputation was inappropriate. Outliers were examined and addressed based on predefined criteria to minimize bias [30].
2.6. Data Analysis
Variables were coded and categorized before analysis (Supplementary File S4). Descriptive statistics were reported as frequencies and percentages for categorical variables and means with standard deviations for continuous variables. wealth index derived via principal component analysis [31]. Multilevel logistic regression estimated adjusted odds ratios (AORs) with 95% confidence intervals (CIs). The ICC values > 5% justified multilevel modeling [32]. Variables with p < 0.25 in bivariable analysis and literature‐supported factors were included in multivariable models [33], with multicollinearity assessed using the variance inflation factor < 5 [34].
We employed a multilevel modeling approach to account for the hierarchical structure of the data, with individuals (Level 1) nested within kebeles (Level 2). Four models were estimated sequentially: an empty model without predictors to assess baseline variance between kebeles; a model including only individual‐level variables; a model including only kebele‐level variables; and a final model incorporating both individual‐ and kebele‐level factors. Random intercepts were specified to allow the average outcome to vary across kebeles.
Model fit was evaluated using the deviance statistic (−2 log‐likelihood), with lower values indicating better fit. Comparative performance across models was assessed using the akaike information criterion (AIC) and Bayesian information criterion (BIC), where smaller values denote superior model fit [35]. The proportional change in variance (PCV) was calculated to quantify the reduction in unexplained between‐kebele variance across successive models, and the ICC was used to estimate the proportion of total variance attributable to kebele‐level clustering.
2.7. Statistical Software and Subgroup Analysis
All statistical analyses were conducted using Stata version 18.0 (Stata Corp, College Station, TX, USA) [36]. Descriptive statistics and multilevel logistic regression models were performed to examine associations between individual‐ and community‐level factors and women's perceptions of CBHI. All statistical tests were two‐sided, with a pre‐specified significance level of α = 0.05. Abbreviations, symbols, and statistical terms are clearly defined, and all analyses were performed following the Statistical Analyses and Methods in the Published Literature (SAMPL) guidelines for transparency and reproducibility [37]. We conducted a subgroup analysis stratified by district and by place of residence (urban vs. rural) to explore potential variations across settings.
3. Results
3.1. Random Model Information and Model Fitness
The null model (Model 0) had an ICC of 0.4415, showing that 44% of the variance in women's perception of healthcare access was between kebeles, supporting multilevel modeling. Adding individual‐level factors (Model 1) reduced the ICC to 0.3489, while community‐level factors alone (Model 2) gave 0.4407. The full model (Model 3) produced the lowest ICC (0.1874), reflecting the greatest reduction in between‐kebele variance (Table 1).
Table 1.
Intraclass correlation coefficient estimates for four multilevel models examining women's perceptions of healthcare access in the Sidama Region, Southern Ethiopia, 2024 (n = 835).
| Model No. | Model description | Intraclass correlation coefficient | Std. Err. | 95% Confidence interval |
|---|---|---|---|---|
| 0 | Null model (no predictors) | 0.4415 | 0.1084 | 0.3154–0.8184 |
| 1 | Individual‐level factors | 0.3489 | 0.1474 | 0.2022–0.7237 |
| 2 | Community‐level factors | 0.4407 | 0.1181 | 0.3167–0.7493 |
| 3 | Both individual‐ and community‐level factors (full) | 0.1874 | 0.1531 | 0.0312–0.6232 |
The null model fit poorly (AIC = 734.04; BIC = 743.50), Model 1 improved fit (AIC = 386.74; BIC = 514.39), Model 2 performed worse (AIC = 712.98; BIC = 746.07), and the full model (Model 3) had the best fit (AIC = 386.23; BIC = 499.69), supporting inclusion of both individual‐ and community‐level predictors (Table 2).
Table 2.
Model fit indices for four multilevel models assessing women's perceptions of healthcare access in the Sidama Region, Southern Ethiopia, 2024 (n = 835).
| Model No. | Model description | N | Log likelihood (ll(model)) | Degrees of freedom | AIC | BIC |
|---|---|---|---|---|---|---|
| 0 | Null model (no predictors) | 835 | −365.0211 | 2 | 734.0422 | 743.4971 |
| 1 | Individual‐level factors | 835 | −166.3722 | 27 | 386.7443 | 514.385 |
| 2 | Community‐level factors | 835 | −349.4881 | 7 | 712.9763 | 746.0683 |
| 3 | Both individual‐ and community‐level factors (full) | 835 | −169.1174 | 24 | 386.2348 | 499.6932 |
Abbreviations: AIC: akaike information criterion; BIC, Bayesian information criterion.
3.2. Study Participants Characteristics
In 2024, 835 women from the Central Zone of Sidama Region, Ethiopia, were surveyed. Most lived in low‐poverty communities (57.3%), had low literacy (53.7%), and low community autonomy (51.6%). The majority resided in rural areas (57.9%) and male‐headed households (88.8%), with 60% employed.
Regarding CBHI perceptions, 67.4% reported package inadequacy, 42.3% perceived contributions as unfair, while 59.3% and 57.3% viewed decision‐making as transparent and inclusive, respectively. Acceptance of CBHI was high (63.5%), with 57.5% willing to advocate for it. Positive perceptions were also noted for drug availability (79.5%), quality improvement (82.2%), affordability (81.7%), health service use (78.2%), and financial protection (79.0%). Most participants could read and write (57.3%) and were married (93.7%) (Table 3).
Table 3.
Key background characteristics of women in the Central Zone of Sidama Region, Southern Ethiopia, 2024 (n = 835).
| Variable | Subcategory | Frequency | Percent (%) |
|---|---|---|---|
| Community‐level women's poverty | Low | 478 | 57.3 |
| High | 357 | 42.7 | |
| Community‐level women's literacy | High | 387 | 46.3 |
| Low | 448 | 53.7 | |
| Community‐level women's autonomy | High | 431 | 51.6 |
| Low | 404 | 48.4 | |
| Residence | Rural | 484 | 57.9 |
| Urban | 351 | 42.1 | |
| House head | Female | 94 | 11.2 |
| Male | 741 | 88.8 | |
| Employment | Not employed | 334 | 40.0 |
| Employed | 501 | 60.0 | |
| CBHI packages adequacy | Not adequate | 563 | 67.4 |
| Adequate | 272 | 32.6 | |
| CBHI premium contribution fairness | It is not fair | 353 | 42.3 |
| It is fair | 482 | 57.7 | |
| CBHI decisions transparency | not transparent | 340 | 40.7 |
| It is transparent | 495 | 59.3 | |
| CBHI decisions inclusive | includes sometimes | 357 | 42.7 |
| Includes all times | 478 | 57.3 | |
| CBHI promotion adequacy | It is not adequate | 419 | 50.2 |
| It is adequate | 416 | 49.8 | |
| CBHI strategy acceptable | Yes | 530 | 63.5 |
| No | 305 | 36.5 | |
| Advocate CBHI to others | No | 355 | 42.5 |
| Yes | 480 | 57.5 | |
| CBHI ensures the constant availability of drugs | low to high | 664 | 79.5 |
| None | 171 | 20.5 | |
| CBHI improves healthcare quality | low to high | 686 | 82.2 |
| None | 149 | 17.8 | |
| CBHI provides affordable healthcare | low to high | 682 | 81.7 |
| None | 153 | 18.3 | |
| CBHI ensures health consumption | low to high | 653 | 78.2 |
| None | 182 | 21.8 | |
| CBHI ensures financial protection | low to high | 660 | 79.0 |
| None | 175 | 21.0 | |
| Recoded educational status | Read and write | 479 | 57.3 |
| Do not read and write | 356 | 42.7 | |
| Recoded marital status | Married | 782 | 93.7 |
| Others | 53 | 6.3 |
Abbreviation: CBHI, Community‐based health insurance.
Continuous variables showed a mean age of 38.7 years [standard deviation (SD) = 14.1] and an average family size of 4.82 (SD = 1.47). Participants reported an average of 0.85 health facility visits (SD = 1.26). Walking to the nearest facility took a mean of 44.9 min (SD = 15.6), with waiting times averaging 62 min (SD = 25.4). Overall healthcare satisfaction was low and variable, with a mean score of 11.7 (SD = 17.9) (Table 4).
Table 4.
Descriptive statistics of key continuous variables among women in the Central Zone of Sidama Region, Southern Ethiopia, 2024 (n = 835).
| Continuous variables | Mean | Standard deviation (SD) |
|---|---|---|
| Age | 38.7 | 14.1 |
| Family size | 4.82 | 1.47 |
| Frequency of health facility visits | 0.85 | 1.26 |
| Distance to health facility | 44.9 | 15.6 |
| Waiting times at health facilities | 62.0 | 25.4 |
| Healthcare satisfaction | 11.7 | 17.9 |
3.3. Women's Perceptions of CBHI and Healthcare Access
Most women perceived that CBHI improved healthcare access. Of 835 participants, 547 (65.5%; 95% CI: 62.2–68.7) reported a positive perception, while 288 (34.5%; 95% CI: 31.3–37.8) did not reflect generally favorable views of the program (Figure 1).
Figure 1.

Women's perceptions of community‐based health insurance (CBHI) on healthcare access in the Central Zone of Sidama Region, Ethiopia, 2024 (n = 835).
Perceptions of CBHI's impact differed significantly between rural and urban women. Among rural participants, 269 (76.6%) reported improved access versus 82 (23.4%) who did not, while 278 (57.4%) urban women perceived improvement and 206 (42.6%) did not (χ2 = 33.19, p < 0.001). Rural women were more likely to perceive CBHI as beneficial, likely due to reduced financial barriers and limited local services, whereas urban women reported less impact where health facilities were more accessible (Table 5).
Table 5.
Perceptions of community‐based health insurance (CBHI) on healthcare access by residence among women in the Central Zone, Sidama Region, Southern Ethiopia, 2024 (n = 835).
| CBHI's perception of improved healthcare access | Area of residence | ||
|---|---|---|---|
| Rural (1) | Urban (2) | Total | |
| 0 = No improvement | 82 (28.47%) | 206 (71.53%) | 288 (34.49%) |
| 1 = Improved access | 269 (49.18%) | 278 (50.82%) | 547 (65.51%) |
| Total | 351 (42.04%) | 484 (57.96%) | 835 (100%) |
Note: Pearson chi2 (1) = 33.19, p < 0.001 and CBHI: Community‐based health insurance.
3.4. Determinants of Women's CBHI Perceptions
Multilevel logistic regression identified individual‐ and community‐level determinants of women's perception that CBHI improved healthcare access. Women in low‐poverty communities were over four times more likely to perceive benefits than those in high‐poverty areas (AOR = 4.63; 95% CI: 1.8–9.1). Rural women had lower odds than urban women (AOR = 0.37; 95% CI: 0.18–0.68). Health facility visits increased positive perception (AOR = 4.10; 95% CI: 1.9–8.2), while missed visits reduced it (AOR = 0.55; 95% CI: 0.34–0.88). Perceptions of package adequacy (AOR = 0.29; 95% CI: 0.11–0.61) and contribution fairness (AOR = 0.25; 95% CI: 0.12–0.59) significantly affected perceptions. Acceptance of CBHI was the strongest determinant, with over sixfold higher odds of positive perception (AOR = 6.3; 95% CI: 2.1–13.6) (Table 6).
Table 6.
Multilevel determinants of women's perceptions of community‐based health insurance on healthcare access in the Central Zone, Sidama Region, Southern Ethiopia, 2024 (n = 835).
| Variables | Category | Perceived that the CBHI program improved access to healthcare | COR (95% CI) | AOR (95% CI) | p values | |
|---|---|---|---|---|---|---|
| No (%) | Yes (%) | |||||
| Community‐level women's poverty | Low | 108 (29.4) | 259 (70.6) | 5.50 (1.12– 6.01) | 4.63 (1.81–9.11) | p = 0.034* |
| High | 180 (38.5) | 288 (61.5) | 1 | 1 | ||
| Community‐level women's literacy | High | 72 (18.3) | 322 (81.7) | 4.29 (3.13–5.89) | 1.45 (0.51–4.14) | p = 0.778 |
| Low | 216 (49.0) | 225 (51.0) | 1 | 1 | ||
| Community‐level women's autonomy | High | 108 (25.1) | 323 (74.9) | 2.40 (1.79–3.22) | 0.70 (0.33–1.45) | p = 0.861 |
| Low | 180 (44.6) | 224 (55.4) | 1 | 1 | ||
| Residence | Rural | 206 (42.6) | 278 (57.4) | 0.41 (0.30–0.56) | 0.37 (0.18–0.68) | p = 0.025* |
| Urban | 82 (23.4) | 269 (76.6) | 1 | 1 | ||
| Ever visited a health facility | Yes | 73 (21.2) | 271 (78.8) | 5.89 (2.11–7.96) | 4.10 (1.91–8.20) | p = 0.007* |
| No | 215 (43.8) | 276 (56.2) | 1 | 1 | ||
| CBHI packages adequacy | Not adequate | 276 (47.8) | 301 (52.2) | 0.55 (0.03–0.10) | 0.29 (0.11–0.61) | p < 0.001** |
| Adequate | 12 (4.7) | 246 (95.3) | 1 | 1 | ||
| Premium contribution fairness | Not fair | 272 (60.4) | 178 (39.6) | 0.43 (0.02–0.65) | 0.25 (0.12–0.59) | p < 0.001** |
| Fair | 16 (4.2) | 369 (95.8) | 1 | 1 | ||
| CBHI decisions transparency | Not transparent | 281 (49.7) | 284 (50.3) | 1.03 (0.01–1.06) | 0.93 (0.26–3.32) | p = 0.835 |
| Transparent | 7 (2.6) | 263 (97.4) | 1 | 1 | ||
| CBHI decisions are inclusive | Includes sometimes | 283 (45.1) | 345 (54.9) | 0.63 (0.01–0.87) | 0.31 (0.08–1.17) | p = 0.837 |
| Includes all times | 5 (2.4) | 202 (97.6) | 1 | 1 | ||
| CBHI acceptable strategy | Yes | 42 (7.9) | 489 (92.1) | 8.38 (5.26–21.58) | 6.31 (2.10–13.6) | p < 0.001** |
| No | 246 (80.9) | 58 (19.1) | 1 | 1 | ||
| Advocate CBHI to others | No | 277 (45.1) | 337 (54.9) | 0.06 (0.03–0.12) | 0.78 (0.29–2.11) | p = 0.605 |
| Yes | 11 (5.0) | 210 (95.0) | 1 | 1 | ||
| CBHI ensures constant drug availability | Low to high | 157 (23.7) | 506 (76.3) | 10.30 (6.95–15.27) | 2.78 (0.94–8.18) | p = 0.432 |
| None | 131 (76.2) | 41 (23.8) | 1 | 1 | ||
| CBHI improves the quality of services | Low to high | 164 (23.9) | 522 (76.1) | 15.79 (9.93–25.11) | 2.39 (0.59–9.68) | p = 0.178 |
| None | 124 (83.2) | 25 (16.8) | 1 | 1 | ||
| CBHI provides affordable healthcare | Low to high | 166 (24.4) | 515 (75.6) | 11.83 (7.72–18.12) | 0.75 (0.19–2.92) | p = 0.754 |
| None | 122 (79.2) | 32 (20.8) | 1 | 1 | ||
| CBHI ensures health consumption | Low to high | 158 (24.2) | 494 (75.8) | 7.67 (5.32–11.06) | 1.58 (0.43–5.72) | p = 0.532 |
| None | 130 (71.0) | 53 (29.0) | 1 | 1 | ||
| CBHI ensures financial protection | Low to high | 158 (23.9) | 502 (76.1) | 9.18 (6.26–13.47) | 2.13 (0.68–6.66) | p = 0.392 |
| None | 130 (74.3) | 45 (25.7) | 1 | 1 | ||
| Recoded education | Literate | 128 (27.4) | 340 (72.6) | 2.05 (1.54–2.74) | 1.08 (0.57–2.04) | p = 0.621 |
| Illiterate | 160 (43.6) | 207 (56.4) | 1 | 1 | ||
| Women autonomy | Autonomous | 104 (27.9) | 269 (72.1) | 0.58 (0.44–0.78) | 0.52 (0.21–1.32) | p = 0.290 |
| No autonomous | 184 (39.8) | 278 (60.2) | 1 | 1 | ||
| Distance to health facility © | 1.00 (1.00–1.01) | 1.00 (0.99–1.01) | p = 0.194 | |||
| Waiting times at health facility © | 1.00 (1.00–1.01) | 1.00 (1.00–1.00) | p = 0.643 | |||
| Frequency of health facility visits © | 1.28 (1.13–1.46) | 0.55 (0.34–0.88) | p = 0.042* | |||
| Family size © | 0.99 (0.90–1.09) | 0.91 (0.73–1.12) | p = 0.732 | |||
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; ©, continuous variable; COR, crude odds ratio; 1, reference group; CBHI, Community‐based health insurance.
Significant association (p < 0.05).
Highly significant association (p < 0.01).
4. Discussion
Using a multilevel approach, our study showed that both individual‐ and community‐level factors shape women's perceptions of CBHI. Household poverty, healthcare visits, and program awareness had the strongest effects, while neighborhood poverty, literacy, and autonomy also contributed. Despite CBHI's pro‐poor design, women in high‐poverty areas reported lower perceived benefits, likely due to enrollment barriers and limited awareness. Findings highlight the interplay between personal and contextual factors, emphasizing the need for targeted strategies to enhance CBHI's reach and impact.
Women from low‐poverty communities were significantly more likely to perceive CBHI as improving healthcare access. This is consistent with evidence from sub‐Saharan Africa, where higher socioeconomic status (SES) communities' benefit from better infrastructure, health literacy, and social capital, facilitating awareness and use of services [38, 39]. Reduced strain on facilities in these areas also supports positive perceptions. These findings underscore how community SES shapes both actual and perceived CBHI benefits, highlighting persistent barriers to equitable healthcare [40].
Rural residence substantially reduced the likelihood of perceiving improved healthcare access through CBHI, reflecting persistent rural‐urban disparities. Rural women face shortages of trained staff, medicines, and adequately equipped facilities, compounded by poor transport, limited health information, and lower literacy [41, 42]. These challenges constrain CBHI's reach, highlighting the urgent need for targeted system strengthening and infrastructure investments to achieve equitable access [43]. Although CBHI seeks to improve access, systemic deficits in rural areas limit its perceived benefits [3]. Reduced exposure to formal healthcare also lowers awareness and positive perceptions among rural women, consistent with qualitative evidence from Ethiopia and similar contexts [16, 44].
This study further identified health facility visitation as a strong positive predictor of perceived improvement in healthcare access. Women who had recent encounters with health services under the CBHI scheme were more likely to report tangible benefits, reflecting a direct experiential validation of the program's effectiveness [8]. This finding aligns with behavioral health theories emphasizing that personal experience with healthcare services shapes trust, satisfaction, and subsequent engagement [45].
In contrast, frequent non‐healthcare visitation was inversely associated with perceptions of CBHI benefits, indicating a bidirectional and potentially reinforcing feedback loop whereby utilization enhances trust and perceived value, which in turn motivates further service use [46]. These dynamics highlight the importance of demand‐side factors, including health‐seeking behavior and perceived service quality, in shaping program success [47]. Strategies to encourage healthcare utilization, particularly among marginalized or disengaged groups, are essential for optimizing CBHI's benefits.
Perceptions of CBHI's adequacy and fairness strongly influenced women's views of its effectiveness. Women who considered benefit packages insufficient or contribution mechanisms unfair were far less likely to perceive improved healthcare access. This aligns with prior evidence emphasizing that well‐designed benefits, equitable cost‐sharing, and transparent, inclusive governance are critical for participant satisfaction and program legitimacy [48]. Acceptance of the CBHI strategy itself, reflecting sociocultural fit and trust, was the strongest positive determinant, highlighting that community buy‐in and culturally sensitive implementation are essential for health insurance schemes to achieve meaningful impact [49].
When beneficiaries perceive CBHI as legitimate, responsive, and culturally appropriate, they are more likely to use services and report satisfaction, reinforcing positive perceptions. This aligns with implementation science, which highlights acceptance and contextual fit as essential for uptake and sustainability. Adapting CBHI to local cultural norms, engaging community leaders, and incorporating beneficiary feedback are therefore crucial strategies to strengthen program effectiveness and community trust [50].
4.1. Strengths and Limitations of the Study
This study has several strengths. A large, representative sample of women from the Central Zone of Sidama Region supports generalizability. The inclusion of both individual‐ and community‐level factors enabled a multilevel analysis, capturing social, economic, and program‐related determinants of perceptions. Adjusted odds ratios controlled for confounders, providing reliable estimates. Detailed assessment of CBHI‐specific perceptions (e.g., adequacy, fairness, transparency) adds granularity often absent in broader evaluations. Focusing on women, central to household health decisions, enhances public health relevance. Findings align with previous studies, strengthening external validity.
However, there are limitations. The cross‐sectional design precludes causal inference; positive perceptions may influence healthcare utilization as much as the reverse. Self‐reported data may be affected by recall or social desirability bias. Quantitative methods limit insight into deeper social and cultural factors, highlighting the value of future qualitative studies. Certain influential variables, such as detailed health status and provider perspectives, were not captured, so caution is needed when generalizing beyond this region. Lastly, we acknowledge that, in the absence of actual enrollment data, women's perceptions of CBHI may not fully reflect real uptake. Future studies should investigate how these perceptions translate into actual enrollment to better understand the scheme's impact and effectiveness.
4.2. Implications for Policy and Practice
The findings highlight the need for targeted strategies to improve CBHI effectiveness in Ethiopia and similar low‐income countries. Socioeconomic disparities should be addressed through subsidies or differentiated premiums to enhance access and perceived benefits among poorer communities. Rural health systems require strengthening via staffing, infrastructure, medicine supply, and transportation to ensure coverage translates into actual service use.
CBHI program improvements are essential. Transparent, inclusive decision‐making, fair contributions, and periodic review of benefit packages can build trust and ensure perceived adequacy. Engaging communities in program design fosters ownership and cultural alignment, supporting higher enrollment and satisfaction.
Health promotion and education should emphasize CBHI benefits, particularly for rural and infrequent healthcare users, while local health workers should be trained to communicate advantages and address concerns, boosting program visibility and uptake.
5. Conclusion
This study highlights how social, economic, and programmatic factors shape women's perceptions of CBHI in the Sidama Region. Key determinants include socioeconomic status, rural residence, healthcare use, and views on fairness and cultural fit. Strengthening rural health infrastructure, ensuring transparent and equitable program governance, and culturally tailoring CBHI strategies are essential to improve both perceived and actual benefits. Future longitudinal and mixed‐methods research is needed to further explore these dynamics and guide sustainable policies toward universal health coverage in Ethiopia.
Author Contributions
Kare Chawicha Debessa: conceptualization, investigation, funding acquisition, writing – original draft, methodology, validation, visualization, writing – review and editing, software, formal analysis, project administration, data curation, supervision, resources. Amanuel Yoseph: conceptualization, investigation, funding acquisition, writing – original draft, writing – review and editing, visualization, validation, methodology, software, formal analysis, project administration, data curation, supervision, resources.
Ethics Statement
The study adhered to the Declaration of Helsinki. Ethical approval was obtained from the Institutional Review Board of the College of Medicine and Health Sciences, Hawassa University (IRB/021/16, 22/11/2023). Support letters were secured from the School of Public Health and the Sidama Region Health Bureau and shared with local health authorities. All participants received full information on the study's purpose, procedures, risks, benefits, and confidentiality. Written informed consent was obtained, and interviews were conducted in private locations to ensure comfort and privacy.
Conflicts of Interest
The authors declare no conflicts of interest.
Supporting information
Supporting File 1
Supporting File 2
Supporting File 3
Supporting File 4
Acknowledgments
The authors sincerely express their gratitude to the study participants, data collectors, supervisors, Hawassa University College of Medicine and Health Sciences, Sidama National Regional Health Bureau, and the health offices of Dale Woreda and Yirgalem City for their invaluable contributions. Their support and cooperation were crucial to the successful completion of this study. This study was supported financially by the Sidama National Regional Health Bureau. The funding agency had no role in the study design, data collection, analysis, interpretation, manuscript preparation, or the decision to submit the manuscript for publication.
Data Availability Statement
The data that supports the findings of this study are available in the supporting material of this article.
References
- 1. Darrudi A., Ketabchi Khoonsari M. H., and Tajvar M., “Challenges to Achieving Universal Health Coverage Throughout the World: A Systematic Review,” Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe chi 55, no. 2 (2022): 125–133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. Fadlallah R., El‐Jardali F., Hemadi N., et al., “Barriers and Facilitators to Implementation, Uptake and Sustainability of Community‐Based Health Insurance Schemes in Low‐ and Middle‐Income Countries: A Systematic Review,” International Journal for Equity in Health 17, no. 1 (2018): 13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3. Mulat A. K., Mao W., Bharali I., Balkew R. B., and Yamey G., “Scaling Up Community‐Based Health Insurance in Ethiopia: A Qualitative Study of the Benefits and Challenges,” BMC Health Services Research 22, no. 1 (2022): 473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4. Birhanu Z., Sudhakar M., Jemal M., et al., “Households Willingness to Join and Pay for Community‐Based Health Insurance: Implications for Designing Community‐Based Health Insurance Based on Economic Status in Ethiopia,” PLoS One 20, no. 3 (2025): e0320218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5. Yihdego A. G., Sari A. A., Tajvar M., and Takian A., “Determinants, Challenges, and Opportunities of the Community‐Based Health Insurance Scheme in Tigray Regional State, Ethiopia: A Mixed Method Study,” Journal of Public Health Research 14, no. 4 (2025): 22799036251388587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6. Chemouni B., “The Political Path to Universal Health Coverage: Power, Ideas and Community‐Based Health Insurance in Rwanda,” World development 106 (2018): 87–98. [Google Scholar]
- 7. Muleta E. and Gebre Y., Ethiopia's Economic Reboot: Turning USAID Cuts Into A Catalyst for Change (Institute of Foreign Affairs, 2025). 6. [Google Scholar]
- 8. Debessa K. C., Negeri K. G., and Dangisso M. H., “Women's Enrollment in Community‐Based Health Insurance and Its Determinants in Sidama National Regional State, Ethiopia, 2024: A Multilevel Analysis,” PLoS One 20, no. 2 (2025): e0316948. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9. Zegeye B., Idriss‐Wheeler D., Ahinkorah B. O., et al., “Association Between Women's Household Decision‐Making Autonomy and Health Insurance Enrollment in Sub‐Saharan Africa,” BMC Public Health 23, no. 1 (2023): 610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10. Handebo S., Demie T. G., Woldeamanuel B. T., Biratu T. D., and Gessese G. T., “Enrollment of Reproductive Age Women in Community‐Based Health Insurance: An Evidence From 2019 Mini Ethiopian Demographic and Health Survey,” Frontiers in Public Health 11 (2023): 2023. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11. Osei Afriyie D., Damoah K. A., Mussa E. C., Otchere F., and Tirivayi N., “Barriers and Facilitators to Health Services Utilization Among Households With Free Community‐Based Health Insurance Enrolment in Ethiopia: A Qualitative Study,” SSM ‐ Health Systems 4 (2025): 100066. [Google Scholar]
- 12. Robby K., Nurjazuli N., Izzah L., Tallapessy A., and Astuti I., “From Structure to Outcome: The Role of the Donabedian Model in Global Health Service Management Research (1987–2024),” E3S Web of Conferences 650 (2025): 02025. [Google Scholar]
- 13. Saxena S., Arsh A., Ashraf S., and Gupta N., “Factors Influencing Women's Access to Healthcare Services in Low‐ and Middle‐Income Countries: A Systematic Review: Women's Access to Healthcare in LMICs,” NURSEARCHER (Journal of Nursing & Midwifery Sciences) (2023). [Google Scholar]
- 14. Gessesse A. G. and Hailyesus M., “Community Based Health Insurance (CBHI) System in Southern Ethiopia: An Evaluation of Communication Approach,” Discover Public Health 22, no. 1 (2025): 589. [Google Scholar]
- 15. Debessa K. C., Negeri K. G., and Dangisso M. H., “Barriers and Enablers of Community‐Based Health Insurance Enrollment in the Sidama National Regional State, Southern Ethiopia, 2024: A Qualitative Study,” PLOS Global Public Health 5, no. 9 (2025): e0004310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16. Bayou F. D., Arefaynie M., Tsega Y., et al., “Effect of Community Based Health Insurance on Healthcare Services Utilization in Ethiopia: A Systematic Review and Meta‐Analysis,” BMC Health Services Research 24, no. 1 (2024): 1188. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17. Siraw G., Zewude B., and Meshesha M., “Patterns of Enrollment to Community‐Based Health Insurance and the Situations Influencing Utilization of the Services in Southern Ethiopia: A Qualitative Study,” Cogent Public Health 11, no. 1 (2024): 2338943. [Google Scholar]
- 18. Sidama National Regional Council ., The Constitution of the Sidama National Regional State (Sidama National Regional Council, 2020), 1–108. [Google Scholar]
- 19. Bureau SNRH ., The Sidama National Regional State Health Sector report (Sidama National Regional Health Bureau 2016; ). [Google Scholar]
- 20. Areru H., Dangisso M., and Lindtjorn B., “Low and Unequal Use of Outpatient Health Services in Public Primary Health Care Facilities in Southern Ethiopia: A Facility‐Based Cross‐Sectional Study,” BMC Health Services Research 21, no. 1 (2021): 776. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21. Delgado‐Viñas C. and Gómez‐Moreno M. L., “The Interaction Between Urban and Rural Areas: An Updated Paradigmatic, Methodological and Bibliographic Review,” Land 11 (2022): 1298. [Google Scholar]
- 22. Qassimi N.. Ensuring Ethical Research Practices: A Comprehensive Examination of Actions Aligned With Ethical Principles (2023). [Google Scholar]
- 23. USAID ., Ethiopia's Community‐Based Health Insurance: A Step on The Road to Universal Health Coverage. Health Finance And Governance (USAID, 2015), 2015. [Google Scholar]
- 24. Alimohamadi Y. and Sepandi M., “Considering the Design Effect in Cluster Sampling,” Journal of Cardiovascular and Thoracic Research 11, no. 1 (2019): 78. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25. Yoseph A., Mussie L., and Belayneh M., “Individual, Household, and Community‐Level Determinants of Undernutrition Among Pregnant Women in the Northern Zone of the Sidama Region, Ethiopia: A Multi‐Level Modified Poisson Regression Analysis,” PLoS One 19, no. 12 (2024): e0315681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26. Lakens D., “Sample Size Justification,” Collabra: Psychology 8, no. 1 (2022): 33267. [Google Scholar]
- 27. Nageso D., Tefera K., and Gutema K., “Enrollment in Community Based Health Insurance Program and the Associated Factors Among Households in Boricha District, Sidama Zone, Southern Ethiopia; a Cross‐Sectional Study,” PLoS One 15 (2020): e0234028. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28. Workneh M. H., Bjune G. A., and Yimer S. A., “Prevalence and Associated Factors of Tuberculosis and Diabetes Mellitus Comorbidity: A Systematic Review,” PLoS One 12, no. 4 (2017): e0175925. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29. Bokonda L., Khadija O. T., and Souissi N. Mobile Data Collection Using Open Data Kit. 2019. p. 543‐550.
- 30. Joshi D.‐A. and Patel B., “Data Preprocessing: The Techniques for Preparing Clean and Quality Data for Data Analytics Process,” Oriental Journal of Computer Science and Technology 13 (2021): 78–81. [Google Scholar]
- 31. Kexin X., Achla M., Xinwei D., et al., “Alternative Approaches for Creating a Wealth Index: The Case of Mozambique,” BMJ Global Health 8, no. 8 (2023): e012639. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32. Liljequist D., Elfving B., and Skavberg Roaldsen K., “Intraclass Correlation ‐ A Discussion and Demonstration of Basic Features,” PLoS One 14, no. 7 (2019): e0219854. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33. Assefa N. E., Berhe H., Girma F., et al., “Risk Factors of Premature Rupture of Membranes in Public Hospitals at Mekele City, Tigray, a Case Control Study,” BMC Pregnancy and Childbirth 18, no. 1 (2018): 386. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34. Kim J. H., “Multicollinearity and Misleading Statistical Results,” Korean Journal of Anesthesiology 72, no. 6 (2019): 558–569. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 35. Kasali J. and Adeyemi A. A., “Model‐Data Fit Using Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC), and the Sample‐Size‐Adjusted Bic,” Square: Journal of Mathematics and Mathematics Education 4, no. 1 (2022): 43–51. [Google Scholar]
- 36. Ang S. P., Chia J. E., Deshmukh A. J., et al., “Efficacy and Clinical Outcomes of Catheter Ablation for Atrial Arrhythmia in Cardiac Amyloidosis,” Heart Rhythm: The Official Journal of the Heart Rhythm Society 22, no. 3 (2025): 865–867. [DOI] [PubMed] [Google Scholar]
- 37. Anderson J. M., Wright B., Rauh S., et al., “Evaluation of Indicators Supporting Reproducibility and Transparency Within Cardiology Literature,” Heart 107, no. 2 (2021): 120–126. [DOI] [PubMed] [Google Scholar]
- 38. De Magalhães L. and Santaeulàlia‐Llopis R., “The Consumption, Income, and Wealth of the Poorest: An Empirical Analysis of Economic Inequality in Rural and Urban Sub‐Saharan Africa for Macroeconomists,” Journal of Development Economics 134 (2018): 350–371. [Google Scholar]
- 39. Uzoma A. B., Akintola F. A., Folashade O., and Areghan I., “Financial Inclusion and Poverty Reduction in Sub‐Saharan Africa Region.” in Innovation, Entrepreneurship and the Informal Economy in Sub–Saharan Africa: A Sustainable Development Agenda, eds. Ibidunni A. S., Ogundana O. M., and Olokundun M. A. (Springer Nature Switzerland, 2024), 333–351). [Google Scholar]
- 40. Wanjala B. M., “Women, Poverty, and Empowerment in Africa.” in The Palgrave Handbook of African Women's Studies, eds. Yacob‐Haliso O. and Falola T. (Springer International Publishing, 2021), 1657–1679). [Google Scholar]
- 41. Weeks W. B., Chang J. E., Pagán J. A., et al., “Rural‐Urban Disparities in Health Outcomes, Clinical Care, Health Behaviors, and Social Determinants of Health and An Action‐Oriented, Dynamic Tool for Visualizing Them,” PLOS Glob Public Health 3, no. 10 (2023): e0002420. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 42. Reilly M., “Health Disparities and Access to Healthcare in Rural vs. Urban Areas,” Theory in Action 14 (2021): 6–27. [Google Scholar]
- 43. Weinhold I. and Gurtner S., “Understanding Shortages of Sufficient Health Care in Rural Areas,” Health Policy 118, no. 2 (2014): 201–214. [DOI] [PubMed] [Google Scholar]
- 44. Habte A., Tamene A., Ejajo T., et al., “Towards Universal Health Coverage: The Level and Determinants of Enrollment in the Community‐Based Health Insurance (CBHI) Scheme in Ethiopia: A Systematic Review and Meta‐Analysis,” PLoS One 17, no. 8 (2022): e0272959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 45. Singh P. K., Singh S., Kumari V., and Tiwari M., “Navigating Healthcare Leadership: Theories, Challenges, and Practical Insights for the Future,” Journal of Postgraduate Medicine 70, no. 4 (2024): 232–241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 46. Demissie G. D. and Atnafu A., “Barriers and Facilitators of Community‐Based Health Insurance Membership in Rural Amhara Region, Northwest Ethiopia: A Qualitative Study,” ClinicoEconomics and Outcomes Research: CEOR 13 (2021): 343–348. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 47. Oberoi S., Chaudhary N., Patnaik S., and Singh A., “Understanding Health Seeking Behavior,” Journal of Family Medicine and Primary Care 5 (2016): 463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 48. Balcha B., Endeshaw A. P. M., and Mebratie A., “Household Satisfaction With a Pilot Community‐Based Health Insurance Scheme and Associated Factors in Addis Ababa,” Journal of Public Health Research 12 (2023): 1–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49. Getahun G. K., Kinfe K., and Minwuyelet Z., “The Role of Community‐Based Health Insurance on Healthcare Seeking Behavior of Households in Addis Ababa, Ethiopia,” Preventive Medicine Reports 34 (2023): 102234. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 50. Bayked E. M., Toleha H. N., Zewdie S., Mekonen A. M., Workneh B. D., and Kahissay M. H., “Beneficiaries' Satisfaction With Community‐Based Health Insurance Services and Associated Factors in Ethiopia: A Systematic Review and Meta‐Analysis,” Cost Effectiveness and Resource Allocation: C/E 22, no. 1 (2024): 73. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Supporting File 1
Supporting File 2
Supporting File 3
Supporting File 4
Data Availability Statement
The data that supports the findings of this study are available in the supporting material of this article.
