Abstract
1. Electrical stimulation of the cut peripheral end of the splanchnic nerves results in a biphasic change in electrical conductance measured across the tail of the pancreas. A phase of decreased conductance is followed by a more prolonged phase of increased conductance.
2. Simultaneous measurements of pancreatic blood flow indicate that the phase of decreased conductance occurs as a result of vasoconstriction, whilst the phase of increased conductance is due to vasodilatation.
3. The initial phase of decreased conductance and vasoconstriction is abolished by α-receptor blocking agents such as phenoxybenzamine and the phase of increased conductance blocked by β-receptor blocking agents such as pronethalol.
4. Short periods of electrical stimulation applied to the splanchnic nerves result in a secretion of amylase and a reduction in the volume rate of secretion.
5. When the vasoconstrictor response was abolished by phenoxybenzamine, nerve stimulation still reduced the rate of secretion, suggesting that the inhibitory effect is in part due to a direct action of the secretory cells.
6. After bretylium tosylate, splanchnic nerve stimulation no longer produced vasomotor changes in the pancreas and the inhibitory effect on the volume response was converted to one of augmentation, but the secretion of enzymes was unaffected.
7. The secretion of amylase on splanchnic stimulation was abolished by intravenous injection of atropine, suggesting that a cholinergic mechanism is involved.
8. Noradrenaline did not mobilize pancreatic enzymes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anrep G. V. The influence of the vagus on pancreatic secretion: Second communication. J Physiol. 1916 Dec 15;50(7):421–433. doi: 10.1113/jphysiol.1916.sp001768. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barlow T. E., Greenwell J. R., Harper A. A., Scratcherd T. The effect of adrenaline and noradrenaline on the blood flow, electrical conductance and external secretion of the pancreas. J Physiol. 1971 Sep;217(3):665–678. doi: 10.1113/jphysiol.1971.sp009592. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown J. C., Harper A. A., Scratcherd T. Potentiation of secretin stimulation of the pancreas. J Physiol. 1967 Jun;190(3):519–530. doi: 10.1113/jphysiol.1967.sp008225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CRICK J., HARPER A. A., RAPER H. S. On the preparation of secretin and pancreozymin. J Physiol. 1949 Dec;110(3-4):367–376. doi: 10.1113/jphysiol.1949.sp004445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark D. G., Greenwell J. R., Harper A. A., Sankey A. M., Scratcherd T. The electrical properties of resting and secreting pancreas. J Physiol. 1967 Apr;189(2):247–260. doi: 10.1113/jphysiol.1967.sp008166. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harper A. A., Vass C. C. The control of the external secretion of the pancreas in cats. J Physiol. 1941 Jun 30;99(4):415–435. doi: 10.1113/jphysiol.1941.sp003912. [DOI] [PMC free article] [PubMed] [Google Scholar]
- May O. The relationship of blood-supply to secretion, with especial reference to the pancreas. J Physiol. 1904 Feb 25;30(5-6):400–413. doi: 10.1113/jphysiol.1904.sp001003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHOFIELD B. M. The innervation of the cervix and cornu uteri in the rabbit. J Physiol. 1952 Jul;117(3):317–328. doi: 10.1113/jphysiol.1952.sp004751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TANKEL H. I., HOLLANDER F. The relation between pancreatic secretion and local blood flow: a review. Gastroenterology. 1957 Apr;32(4):633–641. [PubMed] [Google Scholar]