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. 1969 Jul;203(1):1–12. doi: 10.1113/jphysiol.1969.sp008845

Hormone-induced modifications of free tyrosine in the rat thyroid gland

James V Hodge, Kenneth L Melmon, Albert Sjoerdsma
PMCID: PMC1351509  PMID: 5821874

Abstract

The concentrations of free tyrosine in liver, muscle, kidney and thyroid gland were determined in separate groups of rats maintained on a low iodine diet and treated with intraperitoneal injections of thyroxine (T 4), thyrotrophin (TSH) and TSH plus propylthiouracil (PTU). Groups of hypophysectomized rats also were given T 4. Significant changes in tissue tyrosine were generally confined to the thyroid gland. Animals treated with T 4 showed a decrease of mean thyroid tyrosine from 113·3 ± 17·9 (S.D.) μg/g wet weight of gland to 76·2 ± 5·7 μg/g (P < 0·01). Although there was little change in content when TSH was given alone, a significant increase in tyrosine levels was observed when TSH plus PTU were administered (P < 0·01). In hypophysectomized rats thyroid tyrosine decreased and was further lowered (to 46·0 ± 3·1 μg/g; P < 0·05) by T 4 treatment. When tyrosine concentrations were expressed in relation to ribonucleic acid (RNA) or protein content of the assayed gland, all differences in tyrosine content became greater.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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