Abstract
1. Intravenous infusion of angiotensin causes rats which are in water balance to drink water.
2. The mean amount of angiotensin needed to initiate drinking was 29·1 ± 4·6 μg/kg (S.E. of mean) in twenty normal rats, and 15·7 ± 2·1 μg/kg in thirty-four nephrectomized rats.
3. The nephrectomized rat is therefore more sensitive to this action of angiotensin than the rat with intact kidneys.
4. The rates of infusion (0·05-3·0 μg/kg-1 min-1) which cause drinking are comparable to those used to produce other effects in rats.
5. Angiotensin restores the drinking response of the nephrectomized rat subjected to caval ligation to a value similar to that obtained in the uninfused normal rat subjected to caval ligation.
6. The effects of angiotensin and hypertonic saline on drinking are additive when both substances are administered to nephrectomized rats.
7. These experiments provide further support for the view that the renin—angiotensin system is concerned in extracellular thirst.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Akinkugbe O. O., Brown W. C., Cranston W. I. Pressor effects of angiotensin infusions into different vascular beds in the rabbit. Clin Sci. 1966 Jun;30(3):409–416. [PubMed] [Google Scholar]
- Barraclough M. A., Jones N. F., Marsden C. D. Effect of angiotensin on renal function in the rat. Am J Physiol. 1967 May;212(5):1153–1157. doi: 10.1152/ajplegacy.1967.212.5.1153. [DOI] [PubMed] [Google Scholar]
- Bonjour J. P., Regoli D., Roch-Ramel F., Peters G. Prerequisites for the natriuretic effect of val-5-angiotensin II amide in the rat. Am J Physiol. 1968 May;214(5):1133–1138. doi: 10.1152/ajplegacy.1968.214.5.1133. [DOI] [PubMed] [Google Scholar]
- FITZSIMONS J. T. Drinking by nephrectomized rats injected with various substances. J Physiol. 1961 Mar;155:563–579. doi: 10.1113/jphysiol.1961.sp006647. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FITZSIMONS J. T. Drinking by rats depleted of body fluid without increase in osmotic pressure. J Physiol. 1961 Dec;159:297–309. doi: 10.1113/jphysiol.1961.sp006809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FITZSIMONS J. T. The effects of slow infusions of hypertonic solutions on drinking and drinking thresholds in rats. J Physiol. 1963 Jul;167:344–354. doi: 10.1113/jphysiol.1963.sp007154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fitzsimons J. T., Oatley K. Additivity of stimuli for drinking in rats. J Comp Physiol Psychol. 1968 Oct;66(2):450–455. doi: 10.1037/h0026338. [DOI] [PubMed] [Google Scholar]
- Fitzsimons J. T. The role of a renal thirst factor in drinking induced by extracellular stimuli. J Physiol. 1969 Apr;201(2):349–368. doi: 10.1113/jphysiol.1969.sp008760. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malvin R. L., Vander A. J. Effects of angiotensin infusion on renal function in the unanesthetized rat. Am J Physiol. 1967 Nov;213(5):1205–1208. doi: 10.1152/ajplegacy.1967.213.5.1205. [DOI] [PubMed] [Google Scholar]
- PEART W. S. THE RENIN-ANGIOTENSIN SYSTEM. Pharmacol Rev. 1965 Jun;17:143–182. [PubMed] [Google Scholar]
- REGOLI D., RINIKER B., BRUNNER H. The enzymatic degradation of various angiotensin II derivatives by serum, plasma or kidney homogenate. Biochem Pharmacol. 1963 Jul;12:637–646. doi: 10.1016/0006-2952(63)90039-x. [DOI] [PubMed] [Google Scholar]
- Wolf G., Handal P. J. Aldosterone-induced sodium appetite: dose-response and specificity. Endocrinology. 1966 Jun;78(6):1120–1124. doi: 10.1210/endo-78-6-1120. [DOI] [PubMed] [Google Scholar]