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. 1969 Jul;203(1):159–171. doi: 10.1113/jphysiol.1969.sp008857

The effect of hypothalamic lesions on the melanocyte-stimulating hormone content and histology of the pars intermedia of the rat pituitary gland

A Howe, A J Thody
PMCID: PMC1351521  PMID: 5821868

Abstract

1. The effect of bilateral lesions in the anterior hypothalamus on the histology and content of melanocyte-stimulating hormone (MSH) of the pars intermedia has been studied in the adult male rat.

2. By 7-15 days striking histological changes, suggestive of hyperactivity, were evident. These changes were accompanied by an elevated MSH content, which was particularly noticeable at 7 days.

3. By 7 days there was an increase in the acid phosphatase activity of pars intermedia cells, as demonstrated histochemically.

4. It was concluded that a hypothalamic control system exists for the mammalian pars intermedia and may involve both inhibitory and excitatory components.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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